Harvey rat sarcoma virus oncogene

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Synonym

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Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:35.50 artery/aorta:357.10 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:8.77 cerebellum:8.55 brain stem:8.82 corpus callosum/glia:- pineal gland:- peripheral nerve:9.05 spine:- retina:- eye:8.68 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:8.15 thymus:8.01 bone marrow:8.62 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:58.20 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:53.20        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:8.68 muscle:9.25 esophagus:- stomach:- intestine:8.32 colon:8.35 liver/hepato:- lung:- bladder:- kidney:8.47 pituitary:8.09 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001130441
Gene ID 293621
Unigene ID Rn.102180
Probe set ID M13011cds_at  [RG_U34A]
Ensembl ID ENSRNOG00000016611

Orthologous Gene

Human[3]  NM_001130442, NM_005343, NM_176795
Mouse[6]  NM_001130443, NM_001130444, NM_008284

Chromosomal Region

1q41  [201,385,708  -  201,388,987]

Gene Family (Interpro ID)

IPR006688  ADP-ribosylation factor
IPR006689  ARF/SAR superfamily
IPR013684  MIRO-like
IPR002041  Ran GTPase
IPR013753  Ras
IPR001806  Ras GTPase
IPR020849  Ras small GTPase
IPR003579  Ras small GTPase, Rab type
IPR003577  Ras small GTPase, Ras type
IPR005225  Small GTP-binding protein
IPR020851  Small GTPase
IPR003578  Small GTPase, Rho type

Link to Pubmed  (Pubmed ID)

2006160
3023901
8098541
8316835
9487126
9679960
12077341
12107060
12477932
12507937
12695509
12824760
14984964
14988264
15037605
15060019
15831492
15837622
15917294
16153441
16568090
16717102
16895916
17380122
18005061
18163378
18218323
18367547
18408766
18454179
18514235
18556515
19029245
19283661
19303097
19319189
19616040
19652463
19762144
19855393
19878719
19966300
20603646
22177953
22829592
23648844

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0006915  apoptosis
GO:0007569  cell aging
GO:0007050  cell cycle arrest
GO:0008283  cell proliferation
GO:0006897  endocytosis
GO:0006917  induction of apoptosis
GO:0007093  mitotic cell cycle checkpoint
GO:0008285  negative regulation of cell proliferation
GO:0010629  negative regulation of gene expression
GO:0043524  negative regulation of neuron apoptosis
GO:0034259  negative regulation of Rho GTPase activity
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0010628  positive regulation of gene expression
GO:0046330  positive regulation of JNK cascade
GO:0043406  positive regulation of MAP kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0032855  positive regulation of Rac GTPase activity
GO:0035022  positive regulation of Rac protein signal transduction
GO:0046579  positive regulation of Ras protein signal transduction
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0051291  protein heterooligomerization
GO:0007265  Ras protein signal transduction
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0032228  regulation of synaptic transmission, GABAergic
GO:0007264  small GTPase mediated signal transduction
GO:0035176  social behavior
GO:0051146  striated muscle cell differentiation
GO:0008542  visual learning

Cellular Component

GO:0005794  Golgi apparatus
GO:0000139  Golgi membrane
GO:0043231  intracellular membrane-bounded organelle
GO:0005886  plasma membrane

Molecular Function

GO:0005525  GTP binding
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0008022  protein C-terminus binding