NK3 homeobox 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:303.70 ovary:- testis:- heart:38.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001034144
Gene ID 305999
Unigene ID Rn.43468
Probe set ID -
Ensembl ID ENSRNOG00000015477

Orthologous Gene

Human[3]  NM_006167
Mouse[1]  NM_010921

Chromosomal Region

15p11  [49,743,313  -  49,745,903]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

12477932
16782701
19797053

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0030521  androgen receptor signaling pathway
GO:0060442  branching involved in prostate gland morphogenesis
GO:0048754  branching morphogenesis of a tube
GO:0071456  cellular response to hypoxia
GO:0071347  cellular response to interleukin-1
GO:0071383  cellular response to steroid hormone stimulus
GO:0071356  cellular response to tumor necrosis factor
GO:0060664  epithelial cell proliferation involved in salivary gland morphogenesis
GO:0007507  heart development
GO:0008584  male gonad development
GO:0001656  metanephros development
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0060770  negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0010629  negative regulation of gene expression
GO:0043569  negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045930  negative regulation of mitotic cell cycle
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0060037  pharyngeal system development
GO:0043280  positive regulation of caspase activity
GO:0010942  positive regulation of cell death
GO:0051781  positive regulation of cell division
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0045931  positive regulation of mitotic cell cycle
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045860  positive regulation of protein kinase activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0043491  protein kinase B signaling cascade
GO:0033574  response to testosterone stimulus
GO:0007431  salivary gland development
GO:0001756  somitogenesis

Cellular Component

GO:0005622  intracellular
GO:0005634  nucleus

Molecular Function

GO:0004882  androgen receptor activity
GO:0008656  caspase activator activity
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0030284  estrogen receptor activity
GO:0030331  estrogen receptor binding
GO:0042826  histone deacetylase binding
GO:0030295  protein kinase activator activity
GO:0043621  protein self-association
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding