Mdm2 p53 binding protein homolog (mouse)

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:59.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:177.70 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:156 thymus:- bone marrow:- adipose:147.20 bone:- skin:-
GeneChip cerebrum:5.54 cerebellum:6.17 brain stem:5.71 corpus callosum/glia:- pineal gland:- peripheral nerve:5.29 spine:- retina:- eye:6.67 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.51 thymus:6.93 bone marrow:6.08 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:119.50 prostate:38 ovary:- testis:905.80 heart:- muscle:- esophagus:- stomach:- intestine:- colon:289.90     liver/hepato:26.60        lung:50.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.05 muscle:6.97 esophagus:- stomach:- intestine:6.43 colon:6.28 liver/hepato:- lung:- bladder:- kidney:5.78 pituitary:6.53 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001108099
Gene ID 314856
Unigene ID Rn.91829
Probe set ID rc_AI639488_at  [RG_U34A]
Ensembl ID ENSRNOG00000006304

Orthologous Gene

Human[4]  NM_002392
Mouse[2]  NM_010786

Chromosomal Region

7q22  [56,996,694  -  57,020,926]

Gene Family (Interpro ID)

IPR016495  p53 negative regulator Mdm2/Mdm4
IPR003121  SWIB/MDM2 domain

Link to Pubmed  (Pubmed ID)

1614537
8058315
8417333
11983168
14555611
14558917
14625023
14642282
14644432
14667141
15165363
15199126
15456867
15563574
15619210
15656374
15777295
15810085
15844214
16091747
16330492
16339144
16505435
16598789
16601750
16737965
16790648
16914427
17000718
17060322
17107963
17659301
17881359
17905399
18045764
18469520
18614532
18784257
19103650
19136059
19165225
19450511
19638633
19752772
19819240
19850968
19950214
20019189
21281824
21498419
22046440
22405968
22835827
23051735
23262034
24003224
24334056

Gene Ontology  (GO ID)

Biological Process

GO:0071229  cellular response to acid
GO:0071312  cellular response to alkaloid
GO:0071236  cellular response to antibiotic
GO:0071391  cellular response to estrogen stimulus
GO:0071363  cellular response to growth factor stimulus
GO:0070301  cellular response to hydrogen peroxide
GO:0071456  cellular response to hypoxia
GO:0071407  cellular response to organic cyclic substance
GO:0071310  cellular response to organic substance
GO:0071375  cellular response to peptide hormone stimulus
GO:0071494  cellular response to UV-C
GO:0071301  cellular response to vitamin B1
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0045184  establishment of protein localization
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0071157  negative regulation of cell cycle arrest
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010629  negative regulation of gene expression
GO:0010955  negative regulation of protein maturation by peptide bond cleavage
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0018205  peptidyl-lysine modification
GO:0045787  positive regulation of cell cycle
GO:0010628  positive regulation of gene expression
GO:0045931  positive regulation of mitotic cell cycle
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046827  positive regulation of protein export from nucleus
GO:0030163  protein catabolic process
GO:0006461  protein complex assembly
GO:0031648  protein destabilization
GO:0034504  protein localization in nucleus
GO:0016567  protein ubiquitination
GO:0042787  protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0042176  regulation of protein catabolic process
GO:0046677  response to antibiotic
GO:0009743  response to carbohydrate stimulus
GO:0042220  response to cocaine
GO:0042493  response to drug
GO:0045472  response to ether
GO:0010039  response to iron ion
GO:0032026  response to magnesium ion
GO:0043278  response to morphine
GO:0048545  response to steroid hormone stimulus
GO:0009636  response to toxin
GO:0007089  traversing start control point of mitotic cell cycle

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016604  nuclear body
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0045202  synapse

Molecular Function

GO:0019899  enzyme binding
GO:0042802  identical protein binding
GO:0002039  p53 binding
GO:0042975  peroxisome proliferator activated receptor binding
GO:0005515  protein binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding