histone deacetylase 4

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:47.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:122.90 bone marrow:- adipose:147.20 bone:39 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:159.30 prostate:75.90 ovary:- testis:82.30 heart:19.40 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:113.80 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_001067733
Gene ID 363287
Unigene ID Rn.23483
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Mouse [0]  

Chromosomal Region

9q36  [91,148,025  -  91,389,766]

Gene Family (Interpro ID)

IPR017320  Histone deacetylase class II, eukaryotic
IPR000286  Histone deacetylase superfamily

Link to Pubmed  (Pubmed ID)

12242305
12477932
12619878
12668657
15057822
16033423
16767219
17011572
18250163
20097749
21255680
21464227
21554860
21586557
21590736
22357862
22360269
22389387
23271793
23480850
23747726
24166750

Gene Ontology  (GO ID)

Biological Process

GO:0006338  chromatin remodeling
GO:0016575  histone deacetylation
GO:0070932  histone H3 deacetylation
GO:0070933  histone H4 deacetylation
GO:0008285  negative regulation of cell proliferation
GO:0045820  negative regulation of glycolysis
GO:0010832  negative regulation of myotube differentiation
GO:0045668  negative regulation of osteoblast differentiation
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0002076  osteoblast development
GO:0034983  peptidyl-lysine deacetylation
GO:0008284  positive regulation of cell proliferation
GO:0033235  positive regulation of protein sumoylation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006476  protein amino acid deacetylation
GO:0010882  regulation of cardiac muscle contraction by calcium ion signaling
GO:0043393  regulation of protein binding
GO:0048742  regulation of skeletal muscle fiber development
GO:0051153  regulation of striated muscle cell differentiation
GO:0014894  response to denervation involved in regulation of muscle adaptation
GO:0042493  response to drug
GO:0070555  response to interleukin-1
GO:0001501  skeletal system development
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0031672  A band
GO:0042641  actomyosin
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0000118  histone deacetylase complex
GO:0031594  neuromuscular junction
GO:0005634  nucleus
GO:0043234  protein complex
GO:0030017  sarcomere
GO:0017053  transcriptional repressor complex
GO:0030018  Z disc

Molecular Function

GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0004407  histone deacetylase activity
GO:0042826  histone deacetylase binding
GO:0003674  molecular_function
GO:0032041  NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969  NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970  NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0030955  potassium ion binding
GO:0033558  protein deacetylase activity
GO:0019901  protein kinase binding
GO:0043565  sequence-specific DNA binding
GO:0033613  transcription activator binding
GO:0003714  transcription corepressor activity
GO:0008134  transcription factor binding
GO:0070491  transcription repressor binding
GO:0008270  zinc ion binding