ADAM metallopeptidase domain 8

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:38 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:118.40 thyroid/parathyroid:- adrenal gland:- pancreas:56.90 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_574584
Gene ID 499285
Unigene ID Rn.106061
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Mouse [0]  

Chromosomal Region

1q41  [199,780,547  -  199,792,725]

Gene Family (Interpro ID)

IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

9670863
17339047
17979891
19373511
19625177
20194813
21728900

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0008150  biological_process
GO:0000902  cell morphogenesis
GO:0016337  cell-cell adhesion
GO:0071456  cellular response to hypoxia
GO:0006954  inflammatory response
GO:0002523  leukocyte migration during inflammatory response
GO:0048247  lymphocyte chemotaxis
GO:0043524  negative regulation of neuron apoptosis
GO:0002675  positive regulation of acute inflammatory response
GO:0045780  positive regulation of bone resorption
GO:0045785  positive regulation of cell adhesion
GO:0002693  positive regulation of cellular extravasation
GO:0050729  positive regulation of inflammatory response
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0033089  positive regulation of T cell differentiation in the thymus
GO:0070245  positive regulation of thymocyte apoptosis
GO:0006508  proteolysis
GO:0022407  regulation of cell-cell adhesion

Cellular Component

GO:0071133  alpha9-beta1 integrin-ADAM8 complex
GO:0071065  alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0009986  cell surface
GO:0005575  cellular_component
GO:0005737  cytoplasm
GO:0032127  dense core granule membrane
GO:0005887  integral to plasma membrane
GO:0032010  phagolysosome
GO:0005886  plasma membrane
GO:0002102  podosome
GO:0042581  specific granule
GO:0070820  tertiary granule

Molecular Function

GO:0005509  calcium ion binding
GO:0050839  cell adhesion molecule binding
GO:0004222  metalloendopeptidase activity
GO:0008237  metallopeptidase activity
GO:0003674  molecular_function
GO:0008270  zinc ion binding