Parkinson disease (autosomal recessive, juvenile) 2, parkin

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:- testis:82.30 heart:19.40 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_020093
Gene ID 56816
Unigene ID Rn.207194
Probe set ID -
Ensembl ID ENSRNOG00000018013

Orthologous Gene

Human[3]  NM_004562, NM_013987, NM_013988
Mouse[2]  NM_016694, NM_013987, NM_013988

Chromosomal Region

1q11  [43,151,361  -  44,146,408]

Gene Family (Interpro ID)

IPR000626  Ubiquitin
IPR019956  Ubiquitin subgroup
IPR019955  Ubiquitin supergroup

Link to Pubmed  (Pubmed ID)

10686358
10737637
11413239
11679592
11999903
12472897
12618056
12629236
12716939
12917442
14530399
14556719
14663185
15252205
15453267
15480834
15576511
15987638
16174552
16332688
16554120
16905117
16955485
17327227
17553932
17873367
17883392
18195004
19033459
19339245
21466165
21613270
21890690
22792159
23152496
23258539
23661642

Gene Ontology  (GO ID)

Biological Process

GO:0008344  adult locomotory behavior
GO:0070842  aggresome assembly
GO:0006914  autophagy
GO:0008219  cell death
GO:0042417  dopamine metabolic process
GO:0051583  dopamine uptake
GO:0007612  learning
GO:0007626  locomotory behavior
GO:0000422  mitochondrion degradation
GO:0032232  negative regulation of actin filament bundle formation
GO:0060548  negative regulation of cell death
GO:0043524  negative regulation of neuron apoptosis
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0090201  negative regulation of release of cytochrome c from mitochondria
GO:0070997  neuron death
GO:0042551  neuron maturation
GO:0042415  norepinephrine metabolic process
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051865  protein autoubiquitination
GO:0070936  protein K48-linked ubiquitination
GO:0070534  protein K63-linked ubiquitination
GO:0019538  protein metabolic process
GO:0006464  protein modification process
GO:0006513  protein monoubiquitination
GO:0000209  protein polyubiquitination
GO:0016567  protein ubiquitination
GO:0042787  protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0010506  regulation of autophagy
GO:0046928  regulation of neurotransmitter secretion
GO:0050804  regulation of synaptic transmission
GO:0051412  response to corticosterone stimulus
GO:0042493  response to drug
GO:0006986  response to unfolded protein
GO:0001964  startle response
GO:0001963  synaptic transmission, dopaminergic
GO:0035249  synaptic transmission, glutamatergic
GO:0006511  ubiquitin-dependent protein catabolic process

Cellular Component

GO:0016235  aggresome
GO:0030054  cell junction
GO:0005737  cytoplasm
GO:0031410  cytoplasmic vesicle
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005794  Golgi apparatus
GO:0000139  Golgi membrane
GO:0005622  intracellular
GO:0045121  membrane raft
GO:0005739  mitochondrion
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane
GO:0043234  protein complex
GO:0008021  synaptic vesicle

Molecular Function

GO:0051087  chaperone binding
GO:0019900  kinase binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0019901  protein kinase binding
GO:0031625  ubiquitin protein ligase binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding