eukaryotic translation initiation factor 2C, 2

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:47.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:39.80 prostate:38 ovary:- testis:- heart:38.80 muscle:- esophagus:- stomach:- intestine:104.70 colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:236.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_021597
Gene ID 59117
Unigene ID Rn.35512
Probe set ID -
Ensembl ID ENSRNOG00000008533

Orthologous Gene

Human[2]  NM_001164623, NM_012154
Mouse[1]  NM_153178, NM_012154

Chromosomal Region

7q34  [110,827,857  -  110,865,589]

Gene Family (Interpro ID)

IPR012337  Polynucleotidyl transferase, ribonuclease H fold
IPR003165  Stem cell self-renewal protein Piwi

Link to Pubmed  (Pubmed ID)

10512872
17728463
20484662

Gene Ontology  (GO ID)

Biological Process

GO:0008150  biological_process
GO:0030154  cell differentiation
GO:0031047  gene silencing by RNA
GO:0006379  mRNA cleavage
GO:0035279  mRNA cleavage involved in gene silencing by miRNA
GO:0035278  negative regulation of translation involved in gene silencing by miRNA
GO:0045947  negative regulation of translational initiation
GO:0060213  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0009791  post-embryonic development
GO:0031054  pre-microRNA processing
GO:0006355  regulation of transcription, DNA-dependent
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005575  cellular_component
GO:0005737  cytoplasm
GO:0000932  cytoplasmic mRNA processing body
GO:0035068  micro-ribonucleoprotein complex
GO:0005845  mRNA cap binding complex
GO:0005634  nucleus
GO:0005844  polysome
GO:0030529  ribonucleoprotein complex
GO:0016442  RNA-induced silencing complex

Molecular Function

GO:0004521  endoribonuclease activity
GO:0070551  endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0046872  metal ion binding
GO:0003674  molecular_function
GO:0003729  mRNA binding
GO:0000340  RNA 7-methylguanosine cap binding
GO:0003723  RNA binding
GO:0035197  siRNA binding