RAD50 homolog (S. cerevisiae)

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:234 thymus:122.90 bone marrow:- adipose:- bone:156.20 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:114.10 testis:247 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:26.60        lung:50.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_022246
Gene ID 64012
Unigene ID Rn.51136
Probe set ID -
Ensembl ID ENSRNOG00000033065

Orthologous Gene

Human[2]  NM_005732
Mouse[2]  NM_009012

Chromosomal Region

10q22  [39,112,733  -  39,164,694]

Gene Family (Interpro ID)

IPR003593  ATPase, AAA+ type, core
IPR007517  Rad50 zinc hook
IPR013134  Zinc hook, Rad50

Link to Pubmed  (Pubmed ID)

10855503
10908350
12615909
14511253
15199173
15607978
16288216
16474176
16498454
18212738
20690856
21533982
22850678

Gene Ontology  (GO ID)

Biological Process

GO:0000075  cell cycle checkpoint
GO:0032508  DNA duplex unwinding
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0006302  double-strand break repair
GO:0033674  positive regulation of kinase activity
GO:0031954  positive regulation of protein amino acid autophosphorylation
GO:0051291  protein heterooligomerization
GO:0007131  reciprocal meiotic recombination
GO:0000019  regulation of mitotic recombination
GO:0006974  response to DNA damage stimulus
GO:0000723  telomere maintenance
GO:0007004  telomere maintenance via telomerase

Cellular Component

GO:0000781  chromosome, telomeric region
GO:0000794  condensed nuclear chromosome
GO:0016234  inclusion body
GO:0030870  Mre11 complex
GO:0000790  nuclear chromatin
GO:0000784  nuclear chromosome, telomeric region
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0045120  pronucleus

Molecular Function

GO:0008408  3'-5' exonuclease activity
GO:0005524  ATP binding
GO:0004003  ATP-dependent DNA helicase activity
GO:0003677  DNA binding
GO:0005515  protein binding
GO:0030674  protein binding, bridging
GO:0000014  single-stranded DNA specific endodeoxyribonuclease activity
GO:0008270  zinc ion binding