caspase 8

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:13.30        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_022277
Gene ID 64044
Unigene ID Rn.54474
Probe set ID -
Ensembl ID ENSRNOG00000012331

Orthologous Gene

Human[11]  NM_001080124, NM_001080125, NM_001228, NM_033355, NM_033356, NM_033358
Mouse[2]  NM_001080126, NM_009812, NM_001228, NM_033355, NM_033356, NM_033358

Chromosomal Region

9q31  [57,389,353  -  57,437,803]

Gene Family (Interpro ID)

IPR017350  Caspase, interleukin-1 beta convertase
IPR001875  Death effector
IPR011029  DEATH-like
IPR011600  Peptidase C14, caspase catalytic
IPR002398  Peptidase C14, caspase precursor p45
IPR015917  Peptidase C14, caspase precursor p45, core

Link to Pubmed  (Pubmed ID)

10197541
11684016
11841995
11964411
12353035
12560102
12753807
12828936
13679576
14993216
15036620
15075251
15590916
15640164
15976052
16127148
16443785
16465389
16493077
16524172
16730193
16987298
17082813
17403612
17431085
17518537
17563067
17880769
18045865
18090083
18096138
18269875
18289516
18410517
18483392
18521931
18570579
18595259
18598848
19001025
19194987
19239902
19407976
19467786
19540304
19621461
19843670
19961901
20448356
20649583
20824644
21788490
21903094
22419868
22427665
23386613
23466459

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0071260  cellular response to mechanical stimulus
GO:0071407  cellular response to organic cyclic substance
GO:0007507  heart development
GO:0008625  induction of apoptosis via death domain receptors
GO:0030225  macrophage differentiation
GO:0008152  metabolic process
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0001841  neural tube formation
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045651  positive regulation of macrophage differentiation
GO:0045862  positive regulation of proteolysis
GO:0051291  protein heterooligomerization
GO:0006508  proteolysis
GO:0051603  proteolysis involved in cellular protein catabolic process
GO:0042981  regulation of apoptosis
GO:0070243  regulation of thymocyte apoptosis
GO:0046677  response to antibiotic
GO:0032025  response to cobalt ion
GO:0009409  response to cold
GO:0032355  response to estradiol stimulus
GO:0045471  response to ethanol
GO:0032496  response to lipopolysaccharide
GO:0034612  response to tumor necrosis factor

Cellular Component

GO:0031265  CD95 death-inducing signaling complex
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0031264  death-inducing signaling complex
GO:0045121  membrane raft
GO:0005739  mitochondrion
GO:0043005  neuron projection
GO:0030690  Noc1p-Noc2p complex
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0043234  protein complex

Molecular Function

GO:0004197  cysteine-type endopeptidase activity
GO:0042802  identical protein binding
GO:0008233  peptidase activity
GO:0002020  protease binding
GO:0005515  protein binding
GO:0005164  tumor necrosis factor receptor binding