phosphodiesterase 2A, cGMP-stimulated

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:71.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:8.63 cerebellum:7.25 brain stem:7.72 corpus callosum/glia:- pineal gland:- peripheral nerve:8.81 spine:- retina:- eye:7.75 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:7.57 thymus:7.28 bone marrow:7.35 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:119.50 prostate:- ovary:- testis:- heart:96.90 muscle:- esophagus:- stomach:- intestine:209.30 colon:-     liver/hepato:-        lung:50.70    bladder:- kidney:63.80 pituitary:118.40 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:7.43 muscle:7.38 esophagus:- stomach:- intestine:7.30 colon:8.13 liver/hepato:- lung:- bladder:- kidney:7.32 pituitary:7.37 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001143847
Gene ID 81743
Unigene ID Rn.100440
Probe set ID U21101_at  [RG_U34A]
Ensembl ID ENSRNOG00000019560

Orthologous Gene

Human[3]  NM_001143839, NM_001146209, NM_002599
Mouse[3]  NM_001008548, NM_001143848, NM_001143849

Chromosomal Region

1q32  [158,921,607  -  159,013,829]

Gene Family (Interpro ID)

IPR002073  3'5'-cyclic nucleotide phosphodiesterase
IPR003018  GAF
IPR003607  Metal-dependent phosphohydrolase, HD domain

Link to Pubmed  (Pubmed ID)

1326532
7811274
12107056
12573460
12834273
16651469
17329248
17376027
17561940
18499090
18684888
19003918
19506089
20175220
21724846
23000621

Gene Ontology  (GO ID)

Biological Process

GO:0006198  cAMP catabolic process
GO:0019933  cAMP-mediated signaling
GO:0071321  cellular response to cGMP
GO:0071260  cellular response to mechanical stimulus
GO:0046069  cGMP catabolic process
GO:0019934  cGMP-mediated signaling
GO:0008152  metabolic process
GO:0030224  monocyte differentiation
GO:0030818  negative regulation of cAMP biosynthetic process
GO:0033159  negative regulation of protein import into nucleus, translocation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0043116  negative regulation of vascular permeability
GO:0010628  positive regulation of gene expression
GO:0050729  positive regulation of inflammatory response
GO:0043117  positive regulation of vascular permeability
GO:0006626  protein targeting to mitochondrion

Cellular Component

GO:0030424  axon
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030425  dendrite
GO:0005783  endoplasmic reticulum
GO:0005794  Golgi apparatus
GO:0045121  membrane raft
GO:0005759  mitochondrial matrix
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0042734  presynaptic membrane

Molecular Function

GO:0030552  cAMP binding
GO:0030553  cGMP binding
GO:0004118  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0004112  cyclic-nucleotide phosphodiesterase activity
GO:0008144  drug binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0030911  TPR domain binding