transforming growth factor, beta 2

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:83.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:273.30 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:1139 placenta:119.50 prostate:151.80 ovary:114.10 testis:- heart:135.70 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:152    bladder:- kidney:127.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:227.60 breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_031131
Gene ID 81809
Unigene ID Rn.24539
Probe set ID -
Ensembl ID ENSRNOG00000002418

Orthologous Gene

Human[6]  NM_001135599, NM_003238
Mouse[3]  NM_009367, NM_003238

Chromosomal Region

13q26  [102,718,708  -  102,818,939]

Gene Family (Interpro ID)

IPR001111  Transforming growth factor beta (TGFb), N-terminal
IPR015618  Transforming growth factor beta 3
IPR003911  Transforming growth factor beta TGFb
IPR003940  Transforming growth factor, beta 2
IPR016319  Transforming growth factor-beta
IPR015615  Transforming growth factor-beta-related

Link to Pubmed  (Pubmed ID)

7852342
8106553
8486763
8509457
9779826
10899565
11002343
11014222
11231055
11245570
11500982
11774400
11843059
11906188
11934857
11956143
12051734
12060054
12130550
12150952
12209600
12239085
12416537
12477932
12545247
12595240
12646048
12733949
12815632
12876066
14575314
14612425
14717916
14960316
14997937
15109563
15122060
15145083
15375625
15630473
15746252
15899155
15922484
15927076
15944186
16217485
16227582
16439574
16479080
16479313
16532270
17068209
17117936
17204936
17366323
17516499
17574405
18205704
18378961
18391505
18406405
18471258
18554691
18597229
18790002
19200954
19342245
19434765
19457129
19567205
19656380
20653032
21865583

Gene Ontology  (GO ID)

Biological Process

GO:0032147  activation of protein kinase activity
GO:0006924  activation-induced cell death of T cells
GO:0007568  aging
GO:0007411  axon guidance
GO:0001568  blood vessel development
GO:0001974  blood vessel remodeling
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0060038  cardiac muscle cell proliferation
GO:0010002  cardioblast differentiation
GO:0001502  cartilage condensation
GO:0042637  catagen
GO:0007050  cell cycle arrest
GO:0008219  cell death
GO:0016049  cell growth
GO:0016477  cell migration
GO:0000902  cell morphogenesis
GO:0045216  cell-cell junction organization
GO:0030199  collagen fibril organization
GO:0042416  dopamine biosynthetic process
GO:0048566  embryonic gut development
GO:0048702  embryonic neurocranium morphogenesis
GO:0001837  epithelial to mesenchymal transition
GO:0030198  extracellular matrix organization
GO:0001654  eye development
GO:0060325  face morphogenesis
GO:0007565  female pregnancy
GO:0060364  frontal suture morphogenesis
GO:0008347  glial cell migration
GO:0048565  gut development
GO:0001942  hair follicle development
GO:0031069  hair follicle morphogenesis
GO:0007507  heart development
GO:0003007  heart morphogenesis
GO:0030097  hemopoiesis
GO:0030902  hindbrain development
GO:0006917  induction of apoptosis
GO:0048839  inner ear development
GO:0001822  kidney development
GO:0030324  lung development
GO:0022601  menstrual cycle phase
GO:0010693  negative regulation of alkaline phosphatase activity
GO:0043066  negative regulation of apoptosis
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0050777  negative regulation of immune response
GO:0010936  negative regulation of macrophage cytokine production
GO:0051280  negative regulation of release of sequestered calcium ion into cytosol
GO:0048666  neuron development
GO:0048663  neuron fate commitment
GO:0030593  neutrophil chemotaxis
GO:0031016  pancreas development
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0070237  positive regulation of activation-induced cell death of T cells
GO:0043065  positive regulation of apoptosis
GO:0051891  positive regulation of cardioblast differentiation
GO:0051795  positive regulation of catagen
GO:0033630  positive regulation of cell adhesion mediated by integrin
GO:0045787  positive regulation of cell cycle
GO:0051781  positive regulation of cell division
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0010634  positive regulation of epithelial cell migration
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0010628  positive regulation of gene expression
GO:0045823  positive regulation of heart contraction
GO:0050778  positive regulation of immune response
GO:0045726  positive regulation of integrin biosynthetic process
GO:0043525  positive regulation of neuron apoptosis
GO:0045778  positive regulation of ossification
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0050714  positive regulation of protein secretion
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0006468  protein amino acid phosphorylation
GO:0042981  regulation of apoptosis
GO:0001558  regulation of cell growth
GO:0042127  regulation of cell proliferation
GO:0032909  regulation of transforming growth factor-beta2 production
GO:0009409  response to cold
GO:0034097  response to cytokine stimulus
GO:0042493  response to drug
GO:0032355  response to estradiol stimulus
GO:0043627  response to estrogen stimulus
GO:0001666  response to hypoxia
GO:0034616  response to laminar fluid shear stress
GO:0010243  response to organic nitrogen
GO:0032570  response to progesterone stimulus
GO:0009314  response to radiation
GO:0032526  response to retinoic acid
GO:0033280  response to vitamin D
GO:0009611  response to wounding
GO:0007435  salivary gland morphogenesis
GO:0007519  skeletal muscle tissue development
GO:0001501  skeletal system development
GO:0007184  SMAD protein nuclear translocation
GO:0048103  somatic stem cell division
GO:0030878  thyroid gland development
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0042060  wound healing

Cellular Component

GO:0030424  axon
GO:0005604  basement membrane
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0030141  secretory granule
GO:0005802  trans-Golgi network

Molecular Function

GO:0001540  beta-amyloid binding
GO:0008083  growth factor activity
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0047485  protein N-terminus binding
GO:0005102  receptor binding
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0005160  transforming growth factor beta receptor binding
GO:0005114  type II transforming growth factor beta receptor binding