secreted frizzled-related protein 1

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:177.70 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:156 thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:77.60 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_224987
Gene ID 84402
Unigene ID Rn.163333
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Mouse [0]  

Chromosomal Region

16q12.5  [73,031,517  -  73,067,035]

Gene Family (Interpro ID)

IPR020067  Frizzled-like domain
IPR001134  Netrin domain
IPR018933  Netrin module, non-TIMP type
IPR008993  TIMP-like, OB-fold

Link to Pubmed  (Pubmed ID)

11287180
12813463
15123780
15677765
15972578
16077939
16149051
17540629
20033841
20420713
22290867
22313323
23073828
23085770

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0060346  bone trabecula formation
GO:0007420  brain development
GO:0071392  cellular response to estradiol stimulus
GO:0071391  cellular response to estrogen stimulus
GO:0071363  cellular response to growth factor stimulus
GO:0071504  cellular response to heparin
GO:0071456  cellular response to hypoxia
GO:0071347  cellular response to interleukin-1
GO:0071380  cellular response to prostaglandin E stimulus
GO:0009267  cellular response to starvation
GO:0071356  cellular response to tumor necrosis factor
GO:0071305  cellular response to vitamin D
GO:0071481  cellular response to X-ray
GO:0046546  development of primary male sexual characteristics
GO:0048546  digestive tract morphogenesis
GO:0006309  DNA fragmentation involved in apoptosis
GO:0009950  dorsal/ventral axis specification
GO:0009790  embryonic development
GO:0008585  female gonad development
GO:0008406  gonad development
GO:0030097  hemopoiesis
GO:0002244  hemopoietic progenitor cell differentiation
GO:0060218  hemopoietic stem cell differentiation
GO:0008584  male gonad development
GO:0022601  menstrual cycle phase
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0045578  negative regulation of B cell differentiation
GO:0030514  negative regulation of BMP signaling pathway
GO:0046851  negative regulation of bone remodeling
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0048147  negative regulation of fibroblast proliferation
GO:0010629  negative regulation of gene expression
GO:0046676  negative regulation of insulin secretion
GO:0043508  negative regulation of JUN kinase activity
GO:0030279  negative regulation of ossification
GO:0045668  negative regulation of osteoblast differentiation
GO:0033689  negative regulation of osteoblast proliferation
GO:0045671  negative regulation of osteoclast differentiation
GO:0050732  negative regulation of peptidyl-tyrosine phosphorylation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0014034  neural crest cell fate commitment
GO:0001843  neural tube closure
GO:0021915  neural tube development
GO:0001649  osteoblast differentiation
GO:0090179  planar cell polarity pathway involved in neural tube closure
GO:0043065  positive regulation of apoptosis
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0050679  positive regulation of epithelial cell proliferation
GO:0045600  positive regulation of fat cell differentiation
GO:0045880  positive regulation of smoothened signaling pathway
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687  regulation of branching involved in prostate gland morphogenesis
GO:0010564  regulation of cell cycle process
GO:0090175  regulation of establishment of planar polarity
GO:0030278  regulation of ossification
GO:0042493  response to drug
GO:0014070  response to organic cyclic substance
GO:0035019  somatic stem cell maintenance
GO:0001756  somitogenesis
GO:0001657  ureteric bud development
GO:0001944  vasculature development
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0060071  Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0009986  cell surface
GO:0005575  cellular_component
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005622  intracellular
GO:0005886  plasma membrane
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0004197  cysteine-type endopeptidase activity
GO:0008144  drug binding
GO:0005109  frizzled binding
GO:0008201  heparin binding
GO:0042802  identical protein binding
GO:0003674  molecular_function
GO:0030165  PDZ domain binding
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding