ADAM metallopeptidase domain 8

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同義遺伝子名

CD156a antigen, ADAM metallopeptidase domain 8, CD156, A disintegrin and metalloproteinase domain 8, MGC134985, a disintegrin and metalloproteinase domain 8, Cell surface antigen MS2, ADAM8, MS2, ADAM 8 precursor

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:3.60 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:5.90 動脈:- 静脈:- リンパ節:80.90 末梢血:145.70 脾臓:132.30 胸腺:90.20 骨髄:39.40 脂肪:- 骨:25.60 皮膚:14.40
GeneChip 大脳:5.36 小脳:5.47 脳幹:5.37 脳梁:5.39 松果体:- 末梢神経:5.20 脊柱:5.22 網膜:- 目:- 動脈:5.48 静脈:5.66 リンパ節:6.36 末梢血:- 脾臓:6.62 胸腺:5.64 骨髄:6.64 脂肪:5.52 骨:- 皮膚:5.59
CAGE 大脳:0.18 小脳:- 脳幹:0.43 脳梁:0.47 松果体:0.36 末梢神経:- 脊柱:0.39 網膜:- 目:- 動脈:1.33 静脈:2.63 リンパ節:2.89 末梢血:- 脾臓:2.70 胸腺:1.57 骨髄:- 脂肪:1.44 骨:- 皮膚:-
RNA-seq 大脳:0.00 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.65 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.08 骨:- 皮膚:-
EST 子宮:- 胎盤:21.90 前立腺:- 卵巣:37.30 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:4.90    膀胱:- 腎臓:10.40 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:18.60 唾液腺:-
GeneChip 子宮:5.50 胎盤:5.23 前立腺:5.30 卵巣:5.62 精巣:5.13 心臓:5.39 骨格筋:5.28 食道:5.58 胃:5.91 腸:5.73 結腸:5.64 肝臓:5.63 肺:6.13 膀胱:- 腎臓:5.42 下垂体:5.34 甲状腺:5.50 副腎:5.36 膵臓:5.63 乳腺:5.43 唾液腺:5.41
CAGE 子宮:1.05 胎盤:1.83 前立腺:1.21 卵巣:0.68 精巣:0.69 心臓:0.99 骨格筋:0.63 食道:1.08 胃:- 腸:1.46 結腸:1.68     肝臓:1.16    肺:2.51 膀胱:2.31 腎臓:0.49 下垂体:0.10 甲状腺:0.53 副腎:- 膵臓:0.58 乳腺:1.16 唾液腺:1.58
RNA-seq 子宮:- 胎盤:- 前立腺:0.00 卵巣:0.33 精巣:0.03 心臓:0.00 骨格筋:0.02 食道:- 胃:- 腸:- 結腸:0.23     肝臓:0.16        肺:0.99    膀胱:- 腎臓:0.30 下垂体:- 甲状腺:0.11 副腎:0.24 膵臓:- 乳腺:0.00 唾液腺:-

遺伝子オントロジー  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0000902  cell morphogenesis
GO:0016337  cell-cell adhesion
GO:0071456  cellular response to hypoxia
GO:0006954  inflammatory response
GO:0002523  leukocyte migration during inflammatory response
GO:0048247  lymphocyte chemotaxis
GO:0043524  negative regulation of neuron apoptosis
GO:0002675  positive regulation of acute inflammatory response
GO:0045780  positive regulation of bone resorption
GO:0045785  positive regulation of cell adhesion
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0010954  positive regulation of protein maturation by peptide bond cleavage
GO:0050714  positive regulation of protein secretion
GO:0033089  positive regulation of T cell differentiation in the thymus
GO:0070245  positive regulation of thymocyte apoptosis
GO:0006508  proteolysis
GO:0022407  regulation of cell-cell adhesion

Cellular Component

GO:0071133  alpha9-beta1 integrin-ADAM8 complex
GO:0071065  alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0032127  dense core granule membrane
GO:0005887  integral to plasma membrane
GO:0032010  phagolysosome
GO:0005886  plasma membrane
GO:0002102  podosome
GO:0042581  specific granule
GO:0070820  tertiary granule

Molecular Function

GO:0005509  calcium ion binding
GO:0050839  cell adhesion molecule binding
GO:0004222  metalloendopeptidase activity
GO:0008237  metallopeptidase activity
GO:0005515  protein binding
GO:0043621  protein self-association
GO:0008270  zinc ion binding