leucine-rich repeat kinase 2

 詳細情報を見る

同義遺伝子名

leucine-rich repeat kinase 2, LRRK2, ROCO2, Parkinson disease (autosomal dominant) 8, FLJ45829, DKFZp434H2111, PARK8, Dardarin

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:8.30 小脳:- 脳幹:- 脳梁:58.30 松果体:- 末梢神経:- 脊柱:112.30 網膜:118.60 目:5.90 動脈:- 静脈:- リンパ節:91 末梢血:- 脾臓:- 胸腺:25.80 骨髄:118.10 脂肪:40.30 骨:- 皮膚:57.60
GeneChip nodata
CAGE 大脳:1.99 小脳:- 脳幹:1.81 脳梁:1.62 松果体:1.52 末梢神経:- 脊柱:2.30 網膜:- 目:- 動脈:2.81 静脈:2.25 リンパ節:2.52 末梢血:- 脾臓:2.80 胸腺:0.96 骨髄:- 脂肪:2.08 骨:- 皮膚:-
RNA-seq 大脳:1.56 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.54 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.30 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:32.40 結腸:-     肝臓:21.10        肺:44    膀胱:- 腎臓:62.40 下垂体:- 甲状腺:163.70 副腎:50.80 膵臓:- 乳腺:9.30 唾液腺:-
GeneChip nodata
CAGE 子宮:2.57 胎盤:1.25 前立腺:2.25 卵巣:1.80 精巣:1.46 心臓:2.08 骨格筋:2.12 食道:2.37 胃:- 腸:1.29 結腸:1.64     肝臓:1.01    肺:4.54 膀胱:2.14 腎臓:3.07 下垂体:1.87 甲状腺:1.72 副腎:- 膵臓:1.98 乳腺:1.16 唾液腺:1.82
RNA-seq 子宮:- 胎盤:- 前立腺:2.24 卵巣:1.40 精巣:1.42 心臓:1.12 骨格筋:1.03 食道:- 胃:- 腸:- 結腸:2.08     肝臓:0.77        肺:3.37    膀胱:- 腎臓:3.16 下垂体:- 甲状腺:1.03 副腎:1.02 膵臓:- 乳腺:1.20 唾液腺:-

詳細情報

IDs

Refseq ID NM_198578
Gene ID 120892
Unigene ID Hs.187636
Probe set ID -
Ensembl ID ENSG00000188906
GTEx ID ENSG00000188906

オーソログ対応遺伝子

マウス[1]  NM_025730
ラット [0]  

染色体

12q12  [40,590,546  -  40,763,087]

遺伝子ファミリー (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR013753  Ras
IPR001806  Ras GTPase
IPR003579  Ras small GTPase, Rab type
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR005225  Small GTP-binding protein
IPR020851  Small GTPase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0000186  activation of MAPKK activity
GO:0006914  autophagy
GO:0008340  determination of adult lifespan
GO:0006184  GTP catabolic process
GO:0048312  intracellular distribution of mitochondria
GO:0000165  MAPKKK cascade
GO:0034260  negative regulation of GTPase activity
GO:0007406  negative regulation of neuroblast proliferation
GO:0014043  negative regulation of neuron maturation
GO:0007528  neuromuscular junction development
GO:0070997  neuron death
GO:0021772  olfactory bulb development
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0010508  positive regulation of autophagy
GO:0010942  positive regulation of cell death
GO:0060161  positive regulation of dopamine receptor signaling pathway
GO:0043547  positive regulation of GTPase activity
GO:0043068  positive regulation of programmed cell death
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0031398  positive regulation of protein ubiquitination
GO:0046777  protein amino acid autophosphorylation
GO:0040012  regulation of locomotion
GO:0042391  regulation of membrane potential
GO:0006979  response to oxidative stress
GO:0007264  small GTPase mediated signal transduction
GO:0022028  tangential migration from the subventricular zone to the olfactory bulb

Cellular Component

GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0032839  dendrite cytoplasm
GO:0032473  external side of mitochondrial outer membrane
GO:0045121  membrane raft
GO:0005739  mitochondrion
GO:0043005  neuron projection
GO:0005886  plasma membrane
GO:0008021  synaptic vesicle
GO:0005802  trans-Golgi network

Molecular Function

GO:0005524  ATP binding
GO:0005525  GTP binding
GO:0034211  GTP-dependent protein kinase activity
GO:0005096  GTPase activator activity
GO:0003924  GTPase activity
GO:0042802  identical protein binding
GO:0004708  MAP kinase kinase activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0017048  Rho GTPase binding
GO:0015631  tubulin binding