angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

 詳細情報を見る

同義遺伝子名

Angiotensinogen precursor, clade A, SERPINA8, ANHU, AGT

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:40.30 小脳:25.20 脳幹:- 脳梁:29.20 松果体:- 末梢神経:30.70 脊柱:- 網膜:- 目:70.50 動脈:30 静脈:133.30 リンパ節:20.20 末梢血:36.40 脾臓:75.60 胸腺:38.70 骨髄:98.40 脂肪:- 骨:51.20 皮膚:52.80
GeneChip 大脳:9.32 小脳:9.57 脳幹:9.60 脳梁:9.96 松果体:- 末梢神経:7.85 脊柱:11.04 網膜:- 目:- 動脈:7.29 静脈:8.17 リンパ節:5.54 末梢血:- 脾臓:5.29 胸腺:5.31 骨髄:5.82 脂肪:6.06 骨:- 皮膚:5.84
CAGE 大脳:5.69 小脳:- 脳幹:5.53 脳梁:6.07 松果体:3.85 末梢神経:- 脊柱:6.25 網膜:- 目:- 動脈:3.40 静脈:3.24 リンパ節:1.54 末梢血:- 脾臓:0.17 胸腺:0.46 骨髄:- 脂肪:2.64 骨:- 皮膚:-
RNA-seq 大脳:6.83 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.14 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:3.17 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:36.50 胎盤:7.30 前立腺:67.60 卵巣:37.30 精巣:38.90 心臓:63.90 骨格筋:20.10 食道:- 胃:85 腸:194.40 結腸:42.40     肝臓:52.80        肺:39.10    膀胱:- 腎臓:31.20 下垂体:- 甲状腺:- 副腎:- 膵臓:53.30 乳腺:83.60 唾液腺:-
GeneChip 子宮:5.54 胎盤:5.55 前立腺:6.21 卵巣:5.34 精巣:5.93 心臓:8.63 骨格筋:7.21 食道:5.69 胃:6.36 腸:6.55 結腸:5.93 肝臓:11.46 肺:5.62 膀胱:- 腎臓:8.06 下垂体:5.60 甲状腺:5.55 副腎:6.18 膵臓:6.43 乳腺:5.22 唾液腺:5.45
CAGE 子宮:2.47 胎盤:0.88 前立腺:2.49 卵巣:2.10 精巣:1.82 心臓:5.17 骨格筋:3.71 食道:2.34 胃:- 腸:2.20 結腸:1.96     肝臓:8.25    肺:1.46 膀胱:2.44 腎臓:5.09 下垂体:3.31 甲状腺:3.53 副腎:- 膵臓:2.90 乳腺:3.09 唾液腺:1.58
RNA-seq 子宮:- 胎盤:- 前立腺:1.44 卵巣:1.11 精巣:2.13 心臓:4.79 骨格筋:4.03 食道:- 胃:- 腸:- 結腸:2.32     肝臓:10.85        肺:2.31    膀胱:- 腎臓:5.13 下垂体:- 甲状腺:3.60 副腎:4.19 膵臓:- 乳腺:2.54 唾液腺:-

詳細情報

IDs

Refseq ID NM_000029
Gene ID 183
Unigene ID Hs.193832
Probe set ID 202834_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135744
GTEx ID ENSG00000135744

オーソログ対応遺伝子

マウス[1]  NM_007428
ラット [0]  

染色体

1q42.2  [230,838,269  -  230,850,043]

遺伝子ファミリー (Interpro ID)

IPR000227  Angiotensinogen
IPR000215  Protease inhibitor I4, serpin

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0007202  activation of phospholipase C activity
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007568  aging
GO:0002003  angiotensin maturation
GO:0001998  angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0003051  angiotensin-mediated drinking behavior
GO:0014824  artery smooth muscle contraction
GO:0048143  astrocyte activation
GO:0001568  blood vessel development
GO:0001974  blood vessel remodeling
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0007267  cell-cell signaling
GO:0007160  cell-matrix adhesion
GO:0044255  cellular lipid metabolic process
GO:0044267  cellular protein metabolic process
GO:0071260  cellular response to mechanical stimulus
GO:0006883  cellular sodium ion homeostasis
GO:0050663  cytokine secretion
GO:0070371  ERK1 and ERK2 cascade
GO:0008065  establishment of blood-nerve barrier
GO:0007588  excretion
GO:0030198  extracellular matrix organization
GO:0048144  fibroblast proliferation
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007199  G-protein signaling, coupled to cGMP nucleotide second messenger
GO:0006917  induction of apoptosis
GO:0001822  kidney development
GO:0034374  low-density lipoprotein particle remodeling
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0010951  negative regulation of endopeptidase activity
GO:0051387  negative regulation of nerve growth factor receptor signaling pathway
GO:0043524  negative regulation of neuron apoptosis
GO:0034104  negative regulation of tissue remodeling
GO:0007263  nitric oxide mediated signal transduction
GO:0001543  ovarian follicle rupture
GO:0030432  peristalsis
GO:0010535  positive regulation of activation of JAK2 kinase activity
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0010613  positive regulation of cardiac muscle hypertrophy
GO:0032270  positive regulation of cellular protein metabolic process
GO:0010873  positive regulation of cholesterol esterification
GO:0001819  positive regulation of cytokine production
GO:0010595  positive regulation of endothelial cell migration
GO:0045742  positive regulation of epidermal growth factor receptor signaling pathway
GO:0003331  positive regulation of extracellular matrix constituent secretion
GO:0045723  positive regulation of fatty acid biosynthetic process
GO:0048146  positive regulation of fibroblast proliferation
GO:0050729  positive regulation of inflammatory response
GO:0010744  positive regulation of macrophage derived foam cell differentiation
GO:0043410  positive regulation of MAPKKK cascade
GO:0040018  positive regulation of multicellular organism growth
GO:0033864  positive regulation of NAD(P)H oxidase activity
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0046622  positive regulation of organ growth
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0032930  positive regulation of superoxide release
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0002034  regulation of blood vessel size by renin-angiotensin
GO:0002016  regulation of blood volume by renin-angiotensin
GO:0051924  regulation of calcium ion transport
GO:0001558  regulation of cell growth
GO:0042127  regulation of cell proliferation
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0014061  regulation of norepinephrine secretion
GO:0030162  regulation of proteolysis
GO:0002019  regulation of renal output by angiotensin
GO:0019229  regulation of vasoconstriction
GO:0001999  renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure
GO:0002018  renin-angiotensin regulation of aldosterone production
GO:0009409  response to cold
GO:0014873  response to muscle activity involved in regulation of muscle adaptation
GO:0009651  response to salt stress
GO:0051145  smooth muscle cell differentiation
GO:0048659  smooth muscle cell proliferation
GO:0051403  stress-activated MAPK cascade
GO:0042311  vasodilation

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space

Molecular Function

GO:0010698  acetyltransferase activator activity
GO:0008083  growth factor activity
GO:0005179  hormone activity
GO:0005515  protein binding
GO:0004867  serine-type endopeptidase inhibitor activity
GO:0031702  type 1 angiotensin receptor binding
GO:0031703  type 2 angiotensin receptor binding