excision repair cross-complementing rodent repair deficiency, complementation group 2

 詳細情報を見る

同義遺伝子名

DNA excision repair protein ERCC-2, CXPD, XPD, MGC102762, EM9, TTD, MGC126218, XPDC, ERCC2, MGC126219, DNA-repair protein complementing XP-D cells

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:19 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:23.50 動脈:- 静脈:- リンパ節:20.20 末梢血:91.10 脾臓:37.80 胸腺:- 骨髄:19.70 脂肪:- 骨:- 皮膚:9.60
GeneChip nodata
CAGE 大脳:1.75 小脳:- 脳幹:1.71 脳梁:1.95 松果体:1.64 末梢神経:- 脊柱:0.93 網膜:- 目:- 動脈:1.28 静脈:1.53 リンパ節:1.62 末梢血:- 脾臓:1.39 胸腺:1.75 骨髄:- 脂肪:1.25 骨:- 皮膚:-
RNA-seq 大脳:0.34 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.09 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.19 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:7.30 前立腺:22.50 卵巣:74.50 精巣:13 心臓:12.80 骨格筋:20.10 食道:- 胃:21.20 腸:- 結腸:25.40     肝臓:-        肺:4.90    膀胱:- 腎臓:- 下垂体:- 甲状腺:163.70 副腎:- 膵臓:71.10 乳腺:18.60 唾液腺:-
GeneChip nodata
CAGE 子宮:1.50 胎盤:1.22 前立腺:1.64 卵巣:1.31 精巣:2.18 心臓:0.93 骨格筋:1.37 食道:1.48 胃:- 腸:1.37 結腸:1.63     肝臓:1.88    肺:1.20 膀胱:1.58 腎臓:1.61 下垂体:1.38 甲状腺:1.70 副腎:- 膵臓:2.18 乳腺:1.16 唾液腺:1.89
RNA-seq 子宮:- 胎盤:- 前立腺:0.21 卵巣:0.40 精巣:0.36 心臓:0.14 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:0.19     肝臓:0.00        肺:0.14    膀胱:- 腎臓:0.03 下垂体:- 甲状腺:0.50 副腎:0.12 膵臓:- 乳腺:0.20 唾液腺:-

詳細情報

IDs

Refseq ID NM_001130867
Gene ID 2068
Unigene ID Hs.487294
Probe set ID -
Ensembl ID ENSG00000104884
GTEx ID ENSG00000104884

オーソログ対応遺伝子

マウス[1]  NM_007949
ラット [0]  

染色体

19q13.32  [45,854,246  -  45,873,876]

遺伝子ファミリー (Interpro ID)

IPR010614  DEAD2
IPR013020  DNA helicase (DNA repair), Rad3 type
IPR014013  Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR006554  Helicase-like, DEXD box c2 type
IPR001945  Xeroderma pigmentosum group D protein

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0007568  aging
GO:0006915  apoptosis
GO:0030282  bone mineralization
GO:0000075  cell cycle checkpoint
GO:0008283  cell proliferation
GO:0007059  chromosome segregation
GO:0006281  DNA repair
GO:0040016  embryonic cleavage
GO:0043249  erythrocyte maturation
GO:0030198  extracellular matrix organization
GO:0010467  gene expression
GO:0035315  hair cell differentiation
GO:0048820  hair follicle maturation
GO:0060218  hemopoietic stem cell differentiation
GO:0001701  in utero embryonic development
GO:0006917  induction of apoptosis
GO:0006370  mRNA capping
GO:0035264  multicellular organism growth
GO:0032289  myelin formation in the central nervous system
GO:0043066  negative regulation of apoptosis
GO:0006289  nucleotide-excision repair
GO:0000718  nucleotide-excision repair, DNA damage removal
GO:0033683  nucleotide-excision repair, DNA incision
GO:0043388  positive regulation of DNA binding
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0050434  positive regulation of viral transcription
GO:0009791  post-embryonic development
GO:0006468  protein amino acid phosphorylation
GO:0001666  response to hypoxia
GO:0006979  response to oxidative stress
GO:0006362  RNA elongation from RNA polymerase I promoter
GO:0006368  RNA elongation from RNA polymerase II promoter
GO:0021510  spinal cord development
GO:0006363  termination of RNA polymerase I transcription
GO:0006360  transcription from RNA polymerase I promoter
GO:0006366  transcription from RNA polymerase II promoter
GO:0006361  transcription initiation from RNA polymerase I promoter
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0006283  transcription-coupled nucleotide-excision repair
GO:0009650  UV protection
GO:0016032  viral reproduction
GO:0019048  virus-host interaction

Cellular Component

GO:0019907  cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0005737  cytoplasm
GO:0005675  holo TFIIH complex
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005819  spindle
GO:0000441  SSL2-core TFIIH complex

Molecular Function

GO:0051539  4 iron, 4 sulfur cluster binding
GO:0043139  5'-3' DNA helicase activity
GO:0005524  ATP binding
GO:0004003  ATP-dependent DNA helicase activity
GO:0003677  DNA binding
GO:0008094  DNA-dependent ATPase activity
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0004672  protein kinase activity
GO:0047485  protein N-terminus binding
GO:0008353  RNA polymerase II carboxy-terminal domain kinase activity