PTK2B protein tyrosine kinase 2 beta

詳細情報を見る

同義遺伝子名

FADK 2, Cell adhesion kinase beta, PYK2, FAK2, protein tyrosine kinase 2 beta, Protein tyrosine kinase 2 beta, CAKB, Proline-rich tyrosine kinase 2, RAFTK, FADK2, CAK beta, Related adhesion focal tyrosine kinase, PTK, PTK2B protein tyrosine kinase 2 beta, CADTK, PKB, Calcium-dependent tyrosine kinase, Focal adhesion kinase 2, PTK2B

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:55.70 小脳:176.30 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:41.10 動脈:- 静脈:- リンパ節:141.50 末梢血:109.30 脾臓:113.40 胸腺:309.20 骨髄:531.40 脂肪:- 骨:12.80 皮膚:57.60
GeneChip 大脳:6.83 小脳:7.93 脳幹:5.37 脳梁:6.09 松果体:- 末梢神経:5.43 脊柱:5.46 網膜:- 目:- 動脈:5.68 静脈:5.93 リンパ節:7.55 末梢血:- 脾臓:7.43 胸腺:7.64 骨髄:7.75 脂肪:6.14 骨:- 皮膚:6.30
CAGE 大脳:4.49 小脳:- 脳幹:2.48 脳梁:3.44 松果体:2.14 末梢神経:- 脊柱:2.56 網膜:- 目:- 動脈:2.96 静脈:4.53 リンパ節:4.64 末梢血:- 脾臓:4.44 胸腺:4.87 骨髄:- 脂肪:2.71 骨:- 皮膚:-
RNA-seq 大脳:0.95 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.00 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.00 骨:- 皮膚:-
EST 子宮:9.10 胎盤:25.50 前立腺:11.30 卵巣:- 精巣:17.30 心臓:- 骨格筋:- 食道:- 胃:63.70 腸:- 結腸:42.40     肝臓:21.10        肺:34.20    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:8.90 乳腺:18.60 唾液腺:-
GeneChip 子宮:5.54 胎盤:5.24 前立腺:6.03 卵巣:5.74 精巣:5.56 心臓:5.58 骨格筋:5.31 食道:5.84 胃:6.20 腸:6 結腸:6.20 肝臓:6.04 肺:6.53 膀胱:- 腎臓:6.08 下垂体:5.60 甲状腺:6.13 副腎:5.60 膵臓:5.34 乳腺:6.03 唾液腺:6.21
CAGE 子宮:2.93 胎盤:2.60 前立腺:3.47 卵巣:2.10 精巣:2.47 心臓:2.05 骨格筋:1.55 食道:3.15 胃:- 腸:4.10 結腸:3.82     肝臓:2.07    肺:3.77 膀胱:3.01 腎臓:3.17 下垂体:2.62 甲状腺:2.49 副腎:- 膵臓:2.26 乳腺:2.47 唾液腺:3.89
RNA-seq 子宮:- 胎盤:- 前立腺:1.16 卵巣:0.98 精巣:0.50 心臓:0.00 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:0.00     肝臓:0.95        肺:1.06    膀胱:- 腎臓:1.13 下垂体:- 甲状腺:0.32 副腎:0.78 膵臓:- 乳腺:0.00 唾液腺:-

IDs

Refseq ID NM_004103
Gene ID 2185
Unigene ID Hs.491322
Probe set ID 203110_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000120899
GTEx ID ENSG00000120899

オーソログ対応遺伝子

マウス[3]  NM_001162365, NM_001162366, NM_172498
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1718748
7499242
7529876
7544443
7673154
8497321
8670418
8792832
8798684
8838818
8849729
8889548
8939945
8995252
9020138
9091579
9099734
9104812
9242628
9344848
9362541
9402324
9422762
9442086
9446638
9512511
9545257
9560226
9565592
9621077
9750131
9858471
10022914
10022920
10082674
10194422
10229084
10322114
10329689
10354709
10356363
10518561
10521452
10702271
10708762
10713673
10747947
10769033
10777553
10797305
10821841
10867021
10880513
10961871
10980697
11007796
11036077
11149930
11162638
11238453
11278472
11311138
11337490
11352632
11461120
11478920
11493697
11668182
11683411
11739373
11744621
11751905
11774117
11818507
11820787
11850124
11856738
11916084
11937718
12011061
12063569
12077257
12082274
12096713
12231407
12244133
12354773
12458207
12477932
12486027
12515814
12522270
12576483
12578912
12606503
12626562
12628756
12629171
12771146
12771190
12794117
12844492
12857973
12893833
12933673
12943720
12960231
14585963
14676843
14684825
14729602
14961028
14963038
14969582
15050747
15070849
15105428
15128501
15128873
15213840
15489334
15494733
15499613
15539082
15557335
15585656
15588985
15695828
15717329
15778498
15835820
15881658
15944312
15967096
16055703
16202977
16344560
16421571
16433632
16514607
16751776
16760434
16774943
16783820
16840719
16945503
16949788
16998626
17192257
17205062
17329398
17512525
17537919
17551499
17563746
17581868
17716864
17785844
17906699
17910947
17950644
18029348
18075463
18086875
18198130
18365874
18367725
18390748
18437915
18453587
18507841
18571765
18632858
18667434
18765415
18794150
18832579
18954908
19047047
19086031
19106639
19207108
19358827
19380485
19415692
19458494
19509258
19561089
19661918
19700666
19706888
19718025
19880522
19913121
19919693
19930834
20028775
20056178
20074345
20180987
20215112
20308428
20379614
20381867
20543098
20628086
20688918
20724588
20800603
20842205
20849950
20881009
20946164
20966971
21114537
21357692
21424732
21426305
21533080
21602932
21640103
21666110
21840393
21890473
22023045
22096562
22188814
22190034
22454420
22581436
22745829
22842493
22859931
22922962
22923218
22939624
23119100
23142219
23216754
23220172
23259602
23292187
23300847
23302305
23587524
23618355
23922106
23986795
24072693
24108181
24162737
24176282
24598361

遺伝子オントロジー  (GO ID)

Biological Process

GO:0042976  activation of Janus kinase activity
GO:0032863  activation of Rac GTPase activity
GO:0006915  apoptosis
GO:0043534  blood vessel endothelial cell migration
GO:0045453  bone resorption
GO:0007166  cell surface receptor linked signal transduction
GO:0071300  cellular response to retinoic acid
GO:0070098  chemokine-mediated signaling pathway
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0048041  focal adhesion formation
GO:0014009  glial cell proliferation
GO:0007229  integrin-mediated signaling pathway
GO:0000165  MAPKKK cascade
GO:0002315  marginal zone B cell differentiation
GO:0043066  negative regulation of apoptosis
GO:0030502  negative regulation of bone mineralization
GO:0008285  negative regulation of cell proliferation
GO:0045638  negative regulation of myeloid cell differentiation
GO:0043267  negative regulation of potassium ion transport
GO:0031175  neuron projection development
GO:0001556  oocyte maturation
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0030838  positive regulation of actin filament polymerization
GO:0045766  positive regulation of angiogenesis
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0001954  positive regulation of cell-matrix adhesion
GO:0010595  positive regulation of endothelial cell migration
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0010976  positive regulation of neuron projection development
GO:0051000  positive regulation of nitric-oxide synthase activity
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0045860  positive regulation of protein kinase activity
GO:0045727  positive regulation of translation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0006461  protein complex assembly
GO:0050848  regulation of calcium-mediated signaling
GO:0030155  regulation of cell adhesion
GO:0008360  regulation of cell shape
GO:0030826  regulation of cGMP biosynthetic process
GO:0010752  regulation of cGMP-mediated signaling
GO:0032960  regulation of inositol trisphosphate biosynthetic process
GO:0010758  regulation of macrophage chemotaxis
GO:0045428  regulation of nitric oxide biosynthetic process
GO:0051279  regulation of release of sequestered calcium ion into cytosol
GO:0051592  response to calcium ion
GO:0051591  response to cAMP
GO:0042220  response to cocaine
GO:0042493  response to drug
GO:0045471  response to ethanol
GO:0009749  response to glucose stimulus
GO:0009725  response to hormone stimulus
GO:0042542  response to hydrogen peroxide
GO:0001666  response to hypoxia
GO:0010226  response to lithium ion
GO:0009612  response to mechanical stimulus
GO:0006970  response to osmotic stress
GO:0006950  response to stress
GO:0007172  signal complex assembly
GO:0007165  signal transduction
GO:0002040  sprouting angiogenesis
GO:0043149  stress fiber formation
GO:0033209  tumor necrosis factor-mediated signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0030424  axon
GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005925  focal adhesion
GO:0030426  growth cone
GO:0030027  lamellipodium
GO:0045121  membrane raft
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0014069  postsynaptic density

Molecular Function

GO:0043423  3-phosphoinositide-dependent protein kinase binding
GO:0005524  ATP binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0004713  protein tyrosine kinase activity
GO:0004871  signal transducer activity