PTK2B protein tyrosine kinase 2 beta

同義遺伝子名

FADK 2, Cell adhesion kinase beta, PYK2, FAK2, protein tyrosine kinase 2 beta, Protein tyrosine kinase 2 beta, CAKB, Proline-rich tyrosine kinase 2, RAFTK, FADK2, CAK beta, Related adhesion focal tyrosine kinase, PTK, PTK2B protein tyrosine kinase 2 beta, CADTK, PKB, Calcium-dependent tyrosine kinase, Focal adhesion kinase 2, PTK2B

正常組織・臓器 40分類
細胞株・初代培養細胞・成体組織・胎児組織 (FANTOM5 CAGE)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:55.70

小脳:176.30

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:41.10

動脈:-

静脈:-

リンパ節:141.50

末梢血:109.30

脾臓:113.40

胸腺:309.20

骨髄:531.40

脂肪:-

骨:12.80

皮膚:57.60

GeneChip

大脳:6.83

小脳:7.93

脳幹:5.37

脳梁:6.09

松果体:-

末梢神経:5.43

脊柱:5.46

網膜:-

目:-

動脈:5.68

静脈:5.93

リンパ節:7.55

末梢血:-

脾臓:7.43

胸腺:7.64

骨髄:7.75

脂肪:6.14

骨:-

皮膚:6.30

CAGE

大脳:4.49

小脳:-

脳幹:2.48

脳梁:3.44

松果体:2.14

末梢神経:-

脊柱:2.56

網膜:-

目:-

動脈:2.96

静脈:4.53

リンパ節:4.64

末梢血:-

脾臓:4.44

胸腺:4.87

骨髄:-

脂肪:2.71

骨:-

皮膚:-

RNA-seq

大脳:1.92

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:4.95

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:1.54

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:9.10

胎盤:25.50

前立腺:11.30

卵巣:-

精巣:17.30

心臓:-

骨格筋:-

食道:-

胃:63.70

腸:-

結腸:42.40

肝臓:21.10

肺:34.20

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:8.90

乳腺:18.60

唾液腺:-

GeneChip

子宮:5.54

胎盤:5.24

前立腺:6.03

卵巣:5.74

精巣:5.56

心臓:5.58

骨格筋:5.31

食道:5.84

胃:6.20

腸:6

結腸:6.20

肝臓:6.04

肺:6.53

膀胱:-

腎臓:6.08

下垂体:5.60

甲状腺:6.13

副腎:5.60

膵臓:5.34

乳腺:6.03

唾液腺:6.21

CAGE

子宮:2.93

胎盤:2.60

前立腺:3.47

卵巣:2.10

精巣:2.47

心臓:2.05

骨格筋:1.55

食道:3.15

胃:-

腸:4.10

結腸:3.82

肝臓:2.07

肺:3.77

膀胱:3.01

腎臓:3.17

下垂体:2.62

甲状腺:2.49

副腎:-

膵臓:2.26

乳腺:2.47

唾液腺:3.89

RNA-seq

子宮:-

胎盤:-

前立腺:1.05

卵巣:0.55

精巣:1.53

心臓:0.77

骨格筋:0.56

食道:-

胃:-

腸:-

結腸:0.25

肝臓:0.73

肺:2.49

膀胱:-

腎臓:1.36

下垂体:-

甲状腺:0.83

副腎:4.51

膵臓:-

乳腺:1.28

唾液腺:-

IDs

Refseq ID	NM_173175
Gene ID	2185
Unigene ID	Hs.491322
Probe set ID	203110_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000120899
GTEx ID	ENSG00000120899

オーソログ対応遺伝子

マウス[3]	NM_001162365, NM_001162366, NM_172498
ラット [0]

染色体

8p21.2 [27,168,999 - 27,316,903]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR019749	Band 4.1 domain
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0042976	activation of Janus kinase activity
GO:0032863	activation of Rac GTPase activity
GO:0006915	apoptosis
GO:0043534	blood vessel endothelial cell migration
GO:0045453	bone resorption
GO:0007166	cell surface receptor linked signal transduction
GO:0071300	cellular response to retinoic acid
GO:0070098	chemokine-mediated signaling pathway
GO:0007204	elevation of cytosolic calcium ion concentration
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0048041	focal adhesion formation
GO:0014009	glial cell proliferation
GO:0007229	integrin-mediated signaling pathway
GO:0000165	MAPKKK cascade
GO:0002315	marginal zone B cell differentiation
GO:0043066	negative regulation of apoptosis
GO:0030502	negative regulation of bone mineralization
GO:0008285	negative regulation of cell proliferation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0043267	negative regulation of potassium ion transport
GO:0031175	neuron projection development
GO:0001556	oocyte maturation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030838	positive regulation of actin filament polymerization
GO:0045766	positive regulation of angiogenesis
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0001954	positive regulation of cell-matrix adhesion
GO:0010595	positive regulation of endothelial cell migration
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0046330	positive regulation of JNK cascade
GO:0043507	positive regulation of JUN kinase activity
GO:0010976	positive regulation of neuron projection development
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552	positive regulation of phosphoinositide 3-kinase activity
GO:0045860	positive regulation of protein kinase activity
GO:0045727	positive regulation of translation
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0006461	protein complex assembly
GO:0050848	regulation of calcium-mediated signaling
GO:0030155	regulation of cell adhesion
GO:0008360	regulation of cell shape
GO:0030826	regulation of cGMP biosynthetic process
GO:0010752	regulation of cGMP-mediated signaling
GO:0032960	regulation of inositol trisphosphate biosynthetic process
GO:0010758	regulation of macrophage chemotaxis
GO:0045428	regulation of nitric oxide biosynthetic process
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0051592	response to calcium ion
GO:0051591	response to cAMP
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0009749	response to glucose stimulus
GO:0009725	response to hormone stimulus
GO:0042542	response to hydrogen peroxide
GO:0001666	response to hypoxia
GO:0010226	response to lithium ion
GO:0009612	response to mechanical stimulus
GO:0006970	response to osmotic stress
GO:0006950	response to stress
GO:0007172	signal complex assembly
GO:0007165	signal transduction
GO:0002040	sprouting angiogenesis
GO:0043149	stress fiber formation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0030424	axon
GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0030426	growth cone
GO:0030027	lamellipodium
GO:0045121	membrane raft
GO:0005730	nucleolus
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0014069	postsynaptic density

Molecular Function

GO:0043423	3-phosphoinositide-dependent protein kinase binding
GO:0005524	ATP binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity

PTK2B protein tyrosine kinase 2 beta

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function