c-abl oncogene 1, receptor tyrosine kinase

 詳細情報を見る

同義遺伝子名

Abelson murine leukemia viral oncogene homolog 1, ABL1, v-abl, JTK7, Proto-oncogene tyrosine-protein kinase ABL1, c-ABL, ABL

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:69.90 小脳:50.40 脳幹:- 脳梁:87.50 松果体:148.30 末梢神経:30.70 脊柱:112.30 網膜:- 目:99.90 動脈:30 静脈:133.30 リンパ節:60.70 末梢血:18.20 脾臓:94.50 胸腺:38.70 骨髄:118.10 脂肪:40.30 骨:12.80 皮膚:240
GeneChip 大脳:7.39 小脳:6.68 脳幹:7.49 脳梁:8.41 松果体:- 末梢神経:7.38 脊柱:7.96 網膜:- 目:- 動脈:8.32 静脈:8.26 リンパ節:7.30 末梢血:- 脾臓:7.53 胸腺:7.42 骨髄:6.47 脂肪:8.08 骨:- 皮膚:7.72
CAGE 大脳:2.24 小脳:- 脳幹:2.79 脳梁:3.24 松果体:2.36 末梢神経:- 脊柱:2.58 網膜:- 目:- 動脈:3.47 静脈:2.63 リンパ節:2.08 末梢血:- 脾臓:1.89 胸腺:1.56 骨髄:- 脂肪:2.92 骨:- 皮膚:-
RNA-seq 大脳:2.37 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.36 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:4.25 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:72.90 胎盤:36.40 前立腺:157.70 卵巣:298.10 精巣:64.90 心臓:89.40 骨格筋:- 食道:- 胃:85 腸:- 結腸:161.10     肝臓:42.20        肺:48.90    膀胱:- 腎臓:72.80 下垂体:- 甲状腺:- 副腎:- 膵臓:35.60 乳腺:74.30 唾液腺:-
GeneChip 子宮:8.64 胎盤:7.02 前立腺:7.94 卵巣:8.14 精巣:7.28 心臓:7.59 骨格筋:7 食道:7.68 胃:8.11 腸:7.88 結腸:8.56 肝臓:6.87 肺:7.65 膀胱:- 腎臓:7.73 下垂体:7.61 甲状腺:8.35 副腎:7.57 膵臓:6.62 乳腺:8.15 唾液腺:7.79
CAGE 子宮:3.22 胎盤:1.96 前立腺:3.18 卵巣:3.00 精巣:1.90 心臓:2.74 骨格筋:2.05 食道:2.57 胃:- 腸:2.57 結腸:3.03     肝臓:0.84    肺:2.31 膀胱:3.43 腎臓:1.81 下垂体:2.36 甲状腺:2.68 副腎:- 膵臓:1.74 乳腺:2.91 唾液腺:2.12
RNA-seq 子宮:- 胎盤:- 前立腺:5.19 卵巣:4.04 精巣:3.08 心臓:2.08 骨格筋:1.63 食道:- 胃:- 腸:- 結腸:4.63     肝臓:1.33        肺:4.12    膀胱:- 腎臓:2.36 下垂体:- 甲状腺:3.88 副腎:2.43 膵臓:- 乳腺:3.14 唾液腺:-

詳細情報

IDs

Refseq ID NM_005157
Gene ID 25
Unigene ID Hs.431048
Probe set ID 202123_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000097007
GTEx ID ENSG00000097007

オーソログ対応遺伝子

マウス[4]  NM_001112703, NM_009594
ラット [0]  

染色体

9q34.12  [133,589,268  -  133,763,062]

遺伝子ファミリー (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0006914  autophagy
GO:0007411  axon guidance
GO:0007596  blood coagulation
GO:0007155  cell adhesion
GO:0006975  DNA damage induced protein phosphorylation
GO:0042770  DNA damage response, signal transduction
GO:0008630  DNA damage response, signal transduction resulting in induction of apoptosis
GO:0045087  innate immune response
GO:0006298  mismatch repair
GO:0042692  muscle cell differentiation
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0051149  positive regulation of muscle cell differentiation
GO:0051353  positive regulation of oxidoreductase activity
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0006464  protein modification process
GO:0010506  regulation of autophagy
GO:0030155  regulation of cell adhesion
GO:0051726  regulation of cell cycle
GO:0030100  regulation of endocytosis
GO:0000115  regulation of transcription involved in S-phase of mitotic cell cycle
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus

Cellular Component

GO:0015629  actin cytoskeleton
GO:0031252  cell leading edge
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005739  mitochondrion
GO:0031965  nuclear membrane
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0003785  actin monomer binding
GO:0005524  ATP binding
GO:0003677  DNA binding
GO:0000287  magnesium ion binding
GO:0030145  manganese ion binding
GO:0051019  mitogen-activated protein kinase binding
GO:0004515  nicotinate-nucleotide adenylyltransferase activity
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0070064  proline-rich region binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0004713  protein tyrosine kinase activity
GO:0017124  SH3 domain binding
GO:0019905  syntaxin binding