insulin-like growth factor 1 receptor

 詳細情報を見る

同義遺伝子名

insulin-like growth factor 1 receptor, CD221 antigen, IGFIR, IGF1R, MGC142170, IGF-I receptor, JTK13, MGC142172, Insulin-like growth factor 1 receptor precursor, Insulin-like growth factor I receptor, CD221

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST nodata
GeneChip 大脳:7.21 小脳:7.08 脳幹:7.06 脳梁:7.33 松果体:- 末梢神経:7.04 脊柱:7.21 網膜:- 目:- 動脈:7.72 静脈:7.05 リンパ節:6.53 末梢血:- 脾臓:7.17 胸腺:6.83 骨髄:6.89 脂肪:6.41 骨:- 皮膚:7.06
CAGE 大脳:3.12 小脳:- 脳幹:3.02 脳梁:3.19 松果体:3.77 末梢神経:- 脊柱:3.07 網膜:- 目:- 動脈:3.90 静脈:2.54 リンパ節:2.61 末梢血:- 脾臓:2.60 胸腺:2.86 骨髄:- 脂肪:2.79 骨:- 皮膚:-
RNA-seq 大脳:2.53 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.76 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:3.02 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST nodata
GeneChip 子宮:7.64 胎盤:7.74 前立腺:9.13 卵巣:8.67 精巣:6.98 心臓:7.28 骨格筋:5.83 食道:6.98 胃:7.47 腸:6.81 結腸:7.30 肝臓:4.90 肺:7.73 膀胱:- 腎臓:8.59 下垂体:7.30 甲状腺:8.19 副腎:7.96 膵臓:7.75 乳腺:8.11 唾液腺:7.41
CAGE 子宮:3.45 胎盤:3.45 前立腺:3.42 卵巣:3.06 精巣:3.33 心臓:3.01 骨格筋:2.69 食道:2.98 胃:- 腸:2.64 結腸:3.09     肝臓:0.84    肺:3.08 膀胱:3.10 腎臓:3.01 下垂体:3.17 甲状腺:3.31 副腎:- 膵臓:3.40 乳腺:2.74 唾液腺:2.93
RNA-seq 子宮:- 胎盤:- 前立腺:3.35 卵巣:3.31 精巣:3.09 心臓:2.42 骨格筋:2.07 食道:- 胃:- 腸:- 結腸:3.02     肝臓:0.61        肺:3.35    膀胱:- 腎臓:3.15 下垂体:- 甲状腺:4.21 副腎:2.49 膵臓:- 乳腺:2.80 唾液腺:-

詳細情報

IDs

Refseq ID NM_000875
Gene ID 3480
Unigene ID -
Probe set ID 203628_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000140443
GTEx ID ENSG00000140443

オーソログ対応遺伝子

マウス[1]  NM_010513
ラット [0]  

染色体

15q26.3  [99,192,200  -  99,507,759]

遺伝子ファミリー (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0007409  axonogenesis
GO:0007420  brain development
GO:0030010  establishment of cell polarity
GO:0031017  exocrine pancreas development
GO:0006955  immune response
GO:0051389  inactivation of MAPKK activity
GO:0008286  insulin receptor signaling pathway
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0030238  male sex determination
GO:0030879  mammary gland development
GO:0043066  negative regulation of apoptosis
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0014065  phosphoinositide 3-kinase cascade
GO:0048015  phosphoinositide-mediated signaling
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0032467  positive regulation of cytokinesis
GO:0045740  positive regulation of DNA replication
GO:0043410  positive regulation of MAPKKK cascade
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0090031  positive regulation of steroid hormone biosynthetic process
GO:0060740  prostate gland epithelium morphogenesis
GO:0046777  protein amino acid autophosphorylation
GO:0051291  protein heterooligomerization
GO:0051262  protein tetramerization
GO:0046328  regulation of JNK cascade
GO:0033197  response to vitamin E
GO:0007165  signal transduction

Cellular Component

GO:0005901  caveola
GO:0005887  integral to plasma membrane
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0001965  G-protein alpha-subunit binding
GO:0042802  identical protein binding
GO:0043559  insulin binding
GO:0005158  insulin receptor binding
GO:0043560  insulin receptor substrate binding
GO:0005520  insulin-like growth factor binding
GO:0031994  insulin-like growth factor I binding
GO:0005010  insulin-like growth factor receptor activity
GO:0043548  phosphoinositide 3-kinase binding
GO:0005515  protein binding
GO:0004713  protein tyrosine kinase activity