inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

詳細情報を見る

同義遺伝子名

IKK-B, IKBKB, Nuclear factor NF-kappa-B inhibitor kinase beta, I-kappa-B kinase 2, IKK-beta, IKKB, IkBKB, NFKBIKB, MGC131801, IKK2, I-kappa-B-kinase beta

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:- 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:6.11 小脳:6.95 脳幹:6.09 脳梁:6.88 松果体:- 末梢神経:6.72 脊柱:6.67 網膜:- 目:- 動脈:7.10 静脈:6.30 リンパ節:8.24 末梢血:- 脾臓:8.55 胸腺:8.19 骨髄:7.07 脂肪:7.33 骨:- 皮膚:7.50
CAGE 大脳:2.86 小脳:- 脳幹:3.22 脳梁:3.25 松果体:3.04 末梢神経:- 脊柱:3.02 網膜:- 目:- 動脈:3.08 静脈:3.56 リンパ節:3.35 末梢血:- 脾臓:3.23 胸腺:3.10 骨髄:- 脂肪:2.95 骨:- 皮膚:-
RNA-seq 大脳:0.00 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.86 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.61 骨:- 皮膚:-
EST 子宮:9.10 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:8.90 乳腺:- 唾液腺:-
GeneChip 子宮:7.39 胎盤:6.60 前立腺:7.87 卵巣:7.44 精巣:6.49 心臓:6.24 骨格筋:7.27 食道:7.40 胃:7.32 腸:7.11 結腸:6.95 肝臓:6.94 肺:7.68 膀胱:- 腎臓:6.89 下垂体:7.03 甲状腺:7.65 副腎:7.27 膵臓:5.75 乳腺:7.93 唾液腺:7.08
CAGE 子宮:3.25 胎盤:2.78 前立腺:3.09 卵巣:2.96 精巣:2.84 心臓:2.78 骨格筋:2.60 食道:3.02 胃:- 腸:2.88 結腸:3.13     肝臓:2.57    肺:3.02 膀胱:2.83 腎臓:2.73 下垂体:3.17 甲状腺:3.11 副腎:- 膵臓:2.98 乳腺:2.91 唾液腺:3.03
RNA-seq 子宮:- 胎盤:- 前立腺:2.51 卵巣:1.65 精巣:1.42 心臓:0.30 骨格筋:2.48 食道:- 胃:- 腸:- 結腸:1.06     肝臓:0.25        肺:0.00    膀胱:- 腎臓:1.58 下垂体:- 甲状腺:2.64 副腎:1.35 膵臓:- 乳腺:0.41 唾液腺:-

IDs

Refseq ID NM_001556
Gene ID 3551
Unigene ID Hs.597664
Probe set ID 209341_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000104365
GTEx ID ENSG00000104365

オーソログ対応遺伝子

マウス[6]  NM_001159774, NM_010546
ラット[1]  NM_053355, NM_010546

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

8601309
8657102
9214631
9252186
9346241
9346484
9346485
9520446
9632806
9689078
9721103
9744859
9751059
9751060
9763654
9813230
9819420
9878263
9891086
9914500
10022904
10195894
10356400
10469655
10485711
10497169
10521409
10713178
10722755
10723127
10733566
10755617
10779355
10783893
10807933
10848580
10962033
10968790
10980203
11002417
11057907
11080499
11096118
11113112
11120819
11158290
11278268
11359906
11429546
11460167
11527961
11585904
11594795
11606564
11777949
11815618
11821416
11830587
11839743
11864612
11945026
11954826
11959143
11971985
11976329
12054687
12070292
12133833
12210728
12244103
12351658
12393548
12411322
12459277
12477932
12482991
12486103
12486112
12492477
12547194
12589056
12612076
12637324
12645577
12657630
12707358
12709429
12842894
12890679
12943667
14514672
14560022
14585846
14585847
14585990
14597638
14625285
14654787
14702039
14715628
14743216
14990741
15084260
15125834
15128824
15140882
15184390
15217951
15218148
15226300
15254232
15276183
15319427
15383283
15389287
15456791
15489227
15489334
15492226
15494311
15564333
15601829
15749833
15761153
15790681
15802604
15808510
15837793
15856005
15856023
15880043
15951441
16024783
16046471
16051665
16082226
16123045
16126728
16135815
16177806
16207722
16267042
16280329
16286467
16291755
16319058
16344560
16365431
16393995
16424386
16497931
16547522
16583354
16603398
16611882
16728640
16840786
16906147
16920630
16938294
16966325
16982623
16989899
16997282
16998237
17000764
17016640
17047224
17079871
17114296
17145747
17182689
17213322
17237423
17244613
17287217
17363905
17363973
17419715
17446166
17466952
17568778
17616684
17684021
17693255
17703412
17891179
17939994
17947699
17962807
17977820
17997719
18029348
18037881
18163512
18180283
18207244
18260825
18266324
18266467
18308615
18316610
18362886
18408758
18411264
18434448
18456659
18490760
18571841
18583959
18600306
18626576
18636537
18657515
18692471
18949366
18952604
18957422
18981174
18990758
19050262
19104039
19109741
19141566
19150425
19196987
19202066
19243472
19258923
19270264
19365808
19422324
19453261
19488402
19526344
19573080
19591457
19594441
19656241
19675099
19716809
19728335
19730683
19773279
19786027
19815509
19818716
19820708
19850743
20005846
20007573
20026656
20051109
20056178
20068038
20098747
20145131
20152798
20164171
20167598
20176108
20331378
20347815
20368414
20371626
20410276
20421348
20434986
20448038
20448286
20449947
20465575
20503287
20529849
20568250
20600852
20614026
20627395
20657549
20693425
20797629
20803413
20856938
20925653
20932476
20933503
20977779
21029719
21048031
21139048
21204785
21220427
21248029
21317297
21331078
21344388
21390216
21399639
21474709
21482671
21575199
21606193
21606198
21670849
21703539
21724995
21784860
21798539
21803029
21810613
21811235
21903422
21911292
21985298
21987722
21988832
21993219
22022389
22099304
22262057
22331067
22435562
22511786
22605335
22637744
22748238
22766331
22824620
22848663
22863883
22891964
22955948
22990857
23007157
23016877
23017601
23032264
23069812
23090968
23108365
23123196
23178494
23349803
23386606
23453969
23555914
23589370
23636414
23732909
23743204
23774506
23776175
23776406
23792959
23816567
23817200
23872070
23963361
23974204
23986494
24127568
24155403
24240172
24266532
24270572
24322982
24337575
24369075
24450414
24469399
24611898
24613833
24721172
24816145

遺伝子オントロジー  (GO ID)

Biological Process

GO:0001782  B cell homeostasis
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0007252  I-kappaB phosphorylation
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0048011  nerve growth factor receptor signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0010765  positive regulation of sodium ion transport
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0032481  positive regulation of type I interferon production
GO:0006468  protein amino acid phosphorylation
GO:0009615  response to virus
GO:0050852  T cell receptor signaling pathway
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0008385  IkappaB kinase complex
GO:0009898  internal side of plasma membrane
GO:0045121  membrane raft
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0008384  IkappaB kinase activity
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity