interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

詳細情報を見る

同義遺伝子名

CLMF p35, IL-12A, CLMF, IL12A, Interleukin-12 alpha chain precursor, NFSK, NK cell stimulatory factor chain 1, NKSF1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST nodata
GeneChip 大脳:3.28 小脳:3.25 脳幹:3.25 脳梁:3.34 松果体:- 末梢神経:3.33 脊柱:3.32 網膜:- 目:- 動脈:3.27 静脈:3.31 リンパ節:3.20 末梢血:- 脾臓:3.40 胸腺:3.06 骨髄:3.44 脂肪:3.29 骨:- 皮膚:3.39
CAGE 大脳:0.69 小脳:- 脳幹:0.51 脳梁:0.34 松果体:0.62 末梢神経:- 脊柱:0.75 網膜:- 目:- 動脈:0 静脈:0.59 リンパ節:0.60 末梢血:- 脾臓:0.61 胸腺:0 骨髄:- 脂肪:0.26 骨:- 皮膚:-
RNA-seq 大脳:0.55 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.87 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0 骨:- 皮膚:-
EST nodata
GeneChip 子宮:3.15 胎盤:3.18 前立腺:3.20 卵巣:3.41 精巣:3.17 心臓:3.21 骨格筋:3.42 食道:3.64 胃:3.25 腸:3.37 結腸:3.25 肝臓:3.34 肺:3.20 膀胱:- 腎臓:3.22 下垂体:3.25 甲状腺:3.15 副腎:3.13 膵臓:3.64 乳腺:3.23 唾液腺:3.17
CAGE 子宮:0.30 胎盤:0 前立腺:0.21 卵巣:0.37 精巣:0.04 心臓:0.37 骨格筋:0.05 食道:0.68 胃:- 腸:0.21 結腸:0.59     肝臓:0.14    肺:0.94 膀胱:0 腎臓:0.27 下垂体:0 甲状腺:0.17 副腎:- 膵臓:0 乳腺:0.55 唾液腺:0.62
RNA-seq 子宮:- 胎盤:- 前立腺:0.37 卵巣:0.52 精巣:0.52 心臓:0.38 骨格筋:0.18 食道:- 胃:- 腸:- 結腸:0.54     肝臓:0        肺:1.13    膀胱:- 腎臓:0.03 下垂体:- 甲状腺:0.32 副腎:0.86 膵臓:- 乳腺:0.44 唾液腺:-

IDs

Refseq ID NM_000882
Gene ID 3592
Unigene ID -
Probe set ID 207160_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000168811
GTEx ID ENSG00000168811

オーソログ対応遺伝子

マウス[2]  NM_001159424, NM_008351
ラット[1]  NM_053390, NM_008351

染色体

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

934235
1350290
1357073
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2204066
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24040445
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24376289

遺伝子オントロジー  (GO ID)

Biological Process

GO:0007050  cell cycle arrest
GO:0016477  cell migration
GO:0050830  defense response to Gram-positive bacterium
GO:0042832  defense response to protozoan
GO:0006955  immune response
GO:0032700  negative regulation of interleukin-17 production
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0045785  positive regulation of cell adhesion
GO:0032729  positive regulation of interferon-gamma production
GO:0050671  positive regulation of lymphocyte proliferation
GO:0032816  positive regulation of natural killer cell activation
GO:0045954  positive regulation of natural killer cell mediated cytotoxicity
GO:0002860  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0051135  positive regulation of NK T cell activation
GO:0034393  positive regulation of smooth muscle cell apoptosis
GO:0045582  positive regulation of T cell differentiation
GO:0001916  positive regulation of T cell mediated cytotoxicity
GO:0042102  positive regulation of T cell proliferation
GO:0042520  positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0032496  response to lipopolysaccharide
GO:0010224  response to UV-B
GO:0009615  response to virus

Cellular Component

GO:0005737  cytoplasm
GO:0005615  extracellular space
GO:0043514  interleukin-12 complex

Molecular Function

GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0042163  interleukin-12 beta subunit binding
GO:0005143  interleukin-12 receptor binding
GO:0045513  interleukin-27 binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity