interleukin 18 (interferon-gamma-inducing factor)

 詳細情報を見る

同義遺伝子名

IL18, MGC12320, IGIF, interleukin 18 (interferon-gamma-inducing factor), IL-1g, Iboctadekin, Interleukin-18 precursor, IFN-gamma-inducing factor, Interferon-gamma-inducing factor, IL-18, IL-1 gamma, Interleukin-1 gamma, IL1F4

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:1.20 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:118.60 目:35.30 動脈:- 静脈:- リンパ節:10.10 末梢血:- 脾臓:- 胸腺:- 骨髄:39.40 脂肪:- 骨:- 皮膚:4.80
GeneChip 大脳:2.94 小脳:2.79 脳幹:2.99 脳梁:3.15 松果体:- 末梢神経:3.69 脊柱:3.40 網膜:- 目:- 動脈:3.17 静脈:2.72 リンパ節:4.13 末梢血:- 脾臓:3.40 胸腺:3.44 骨髄:3.87 脂肪:3.51 骨:- 皮膚:5.56
CAGE 大脳:2.36 小脳:- 脳幹:3.09 脳梁:3.09 松果体:2.62 末梢神経:- 脊柱:4.09 網膜:- 目:- 動脈:2.81 静脈:3.36 リンパ節:4.28 末梢血:- 脾臓:4.38 胸腺:2.48 骨髄:- 脂肪:3.43 骨:- 皮膚:-
RNA-seq 大脳:0.65 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.49 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.84 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:9.10 胎盤:18.20 前立腺:- 卵巣:- 精巣:- 心臓:12.80 骨格筋:- 食道:- 胃:21.20 腸:32.40 結腸:25.40     肝臓:63.30        肺:53.80    膀胱:- 腎臓:10.40 下垂体:- 甲状腺:- 副腎:- 膵臓:17.80 乳腺:- 唾液腺:-
GeneChip 子宮:3.13 胎盤:2.91 前立腺:3.18 卵巣:2.93 精巣:2.86 心臓:2.90 骨格筋:3.25 食道:6.44 胃:2.98 腸:3.01 結腸:3.48 肝臓:2.97 肺:3.58 膀胱:- 腎臓:3.28 下垂体:3.01 甲状腺:3.02 副腎:2.99 膵臓:2.70 乳腺:3.67 唾液腺:2.84
CAGE 子宮:3.08 胎盤:2.09 前立腺:3.00 卵巣:2.04 精巣:2.12 心臓:1.49 骨格筋:2.22 食道:5.11 胃:- 腸:3.38 結腸:2.96     肝臓:2.31    肺:4.03 膀胱:3.09 腎臓:3.97 下垂体:2.75 甲状腺:2.00 副腎:- 膵臓:2.18 乳腺:2.59 唾液腺:1.89
RNA-seq 子宮:- 胎盤:- 前立腺:1.55 卵巣:0.84 精巣:1.16 心臓:0.00 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:1.16     肝臓:0.89        肺:1.41    膀胱:- 腎臓:0.00 下垂体:- 甲状腺:0.00 副腎:0.00 膵臓:- 乳腺:0.86 唾液腺:-

詳細情報

IDs

Refseq ID NM_001562
Gene ID 3606
Unigene ID Hs.83077
Probe set ID 206295_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000150782
GTEx ID ENSG00000150782

オーソログ対応遺伝子

マウス[1]  NM_008360
ラット[2]  NM_019165

染色体

11q23.1  [112,013,974  -  112,034,840]

遺伝子ファミリー (Interpro ID)

IPR008996  Cytokine, IL-1-like
IPR015529  Interleukin 18
IPR000975  Interleukin-1

Link to Pubmed  (Pubmed ID)

7477296
8666798
8766574
8999548
8999896
9108085
9325300
9334240
9693051
9792649
10000000
10227975
10460493
10639148
10653850
10681439
11466388
11477102
11506998
11598150
11714750
11714826
11770036
11781190
11790772
11798931
11805151
11855785
11888846
11894141
11895335
11905033
11907126
11920321
11936774
11958300
11960649
12096920
12105209
12149432
12172382
12207348
12366781
12377944
12381835
12387830
12390326
12401730
12424620
12438388
12456593
12472176
12472673
12477932
12482935
12517977
12527894
12571842
12572878
12594843
12616343
12654091
12679613
12738632
12748489
12759422
12788305
12794718
12796418
12819633
12847274
12857602
12858406
12874316
12911784
12938205
12941729
12947340
14504095
14556808
14561165
14581397
14584052
14605444
14617033
14630085
14640907
14660053
14662834
14679107
14697936
14709415
14718574
14725568
14734463
14738910
14764217
14960579
14991611
14998974
15005726
15104599
15140035
15212675
15225625
15230817
15277983
15302292
15308504
15326478
15327523
15358638
15371332
15463896
15471361
15489334
15555533
15581980
15585330
15643599
15644127
15645140
15646011
15663745
15674367
15710458
15728489
15731584
15753257
15760905
15786533
15789055
15802534
15806006
15816833
15826815
15842270
15860738
15860756
15863395
15894108
15896202
15927856
15932380
15955098
15963597
16024007
16043644
16049975
16051062
16052331
16053025
16059673
16061751
16078996
16084898
16186395
16215941
16243298
16260350
16266857
16273766
16306550
16306764
16306765
16315783
16316892
16325763
16339124
16358956
16373926
16405895
16406079
16406656
16420594
16424284
16428475
16433722
16433859
16443795
16482511
16492204
16493047
16514436
16516851
16556702
16563174
16571086
16584830
16621994
16635219
16647017
16650813
16671950
16738942
16759385
16767839
16772281
16780720
16806233
16820919
16827865
16839849
16842597
16883062
16903774
16909454
16943580
16948912
16971411
16979683
17001321
17016692
17027359
17055358
17072982
17075246
17077020
17117487
17142727
17192354
17222831
17225121
17225924
17235324
17237446
17252172
17262717
17299019
17301041
17336309
17343316
17355643
17361200
17364073
17373930
17396252
17399992
17445542
17461482
17487222
17517100
17517876
17530707
17586702
17597334
17597823
17605864
17610422
17611614
17611643
17611971
17625598
17626902
17658666
17666338
17671745
17674327
17683383
17687255
17688413
17691022
17703412
17708609
17765248
17767553
17845300
17851127
17851835
17854431
17893261
17907957
17919265
17922692
17948066
17951325
17959666
17962365
17964972
17965486
17981284
17984243
17988833
18024284
18043444
18050195
18050226
18064631
18092318
18093181
18160214
18160936
18163476
18165223
18178861
18200581
18225542
18225563
18235016
18237555
18250135
18279187
18286551
18287807
18295214
18295340
18297714
18307517
18336908
18359638
18386818
18391570
18399311
18433937
18442334
18464913
18484687
18504197
18514203
18514661
18520705
18523012
18538088
18555694
18562922
18566306
18594952
18599493
18628791
18632660
18662786
18678419
18683145
18684981
18685607
18706445
18773860
18777510
18780764
18781864
18803662
18818748
18818761
18819819
18821674
18835036
18853133
18922682
18930181
18937548
18940019
18949051
18983635
19016763
19019335
19031096
19036565
19064572
19073159
19074166
19074885
19077897
19088061
19091595
19092166
19097518
19102398
19110334
19126646
19131059
19138654
19152241
19176284
19178691
19200605
19208460
19229765
19230467
19236760
19247692
19258923
19263242
19265133
19265174
19285156
19288449
19309308
19339355
19342689
19347053
19387647
19390575
19394601
19403407
19420105
19443970
19453784
19455410
19466545
19469892
19470251
19473509
19508433
19509137
19527514
19538326
19550095
19553661
19573080
19581111
19584085
19593889
19605669
19622039
19633236
19637196
19638090
19638429
19639049
19642044
19657406
19669125
19669363
19684151
19687159
19692203
19699611
19712260
19740312
19745201
19757044
19758166
19773279
19789190
19796548
19811440
19816189
19817957
19865096
19879772
19900154
19907017
19913121
19954659
19961286
19961892
20003764
20017708
20056178
20060272
20061784
20083555
20096599
20097272
20137369
20140262
20140691
20150558
20169140
20186552
20216908
20227257
20227263
20233133
20237496
20304021
20306652
20306665
20331838
20331879
20339966
20340055
20349123
20350254
20374388
20399512
20412718
20414054
20416077
20418295
20423837
20424918
20441695
20452482
20478055
20482998
20485444
20490717
20490891
20522205
20525402
20530519
20538124
20545903
20558561
20565717
20568250
20586818
20617584
20627039
20628086
20673868
20689079
20725807
20735470
20797704
20818961
20824296
20885390
20960175
20964873
20971720
21035858
21061265
21118329
21120501
21126942
21139048
21145535
21149337
21149398
21224476
21225442
21239711
21241672
21249128
21264805
21273776
21288140
21321938
21323571
21323573
21334074
21336086
21356600
21382268
21393015
21394384
21395662
21398142
21418456
21418867
21421008
21437204
21440322
21448661
21464751
21470492
21481392
21484426
21487696
21510800
21526496
21532063
21538928
21571262
21611751
21636628
21656327
21661419
21672342
21681500
21710494
21723753
21733366
21742406
21742843
21802664
21832842
21836143
21836147
21840518
21842238
21864160
21867627
21876975
21906983
21922295
21943853
21963094
21965503
21969001
21988832
22008665
22015107
22058412
22125454
22135309
22136483
22141572
22149501
22226490
22228436
22289535
22307326
22325058
22347372
22364914
22373801
22386125
22462419
22468101
22484385
22489883
22493490
22515481
22518072
22531046
22537138
22537218
22587568
22595646
22596175
22613414
22639237
22661400
22664470
22678894
22686311
22723447
22749533
22811364
22825306
22837141
22840759
22863216
22883217
22900713
22913567
22945280
22980562
22996386
23000965
23018032
23023653
23027874
23028054
23056251
23073298
23075512
23085113
23121308
23132931
23137633
23153245
23171362
23178856
23207179
23214284
23232703
23238919
23242610
23257837
23269628
23276493
23298491
23302036
23327592
23403235
23419721
23433789
23459183
23499732
23522322
23526823
23546966
23557801
23587914
23603311
23632060
23656272
23675517
23702484
23702978
23707237
23723976
23741523
23746337
23769880
23778029
23793845
23794112
23856797
23873689
23883285
23885403
23888552
23901078
23904224
23938462
23957657
23978570
24026885
24033965
24040261
24054338
24066061
24130810
24182552
24259949
24265116
24285455
24307760
24331389
24379519
24531812
24717026

遺伝子オントロジー  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007267  cell-cell signaling
GO:0071320  cellular response to cAMP
GO:0070301  cellular response to hydrogen peroxide
GO:0071346  cellular response to interferon-gamma
GO:0071260  cellular response to mechanical stimulus
GO:0071407  cellular response to organic cyclic substance
GO:0071374  cellular response to parathyroid hormone stimulus
GO:0071375  cellular response to peptide hormone stimulus
GO:0071356  cellular response to tumor necrosis factor
GO:0042033  chemokine biosynthetic process
GO:0050966  detection of mechanical stimulus involved in sensory perception of pain
GO:0048546  digestive tract morphogenesis
GO:0042253  granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0006955  immune response
GO:0006954  inflammatory response
GO:0042095  interferon-gamma biosynthetic process
GO:0042231  interleukin-13 biosynthetic process
GO:0042094  interleukin-2 biosynthetic process
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0030324  lung development
GO:0000165  MAPKKK cascade
GO:0030101  natural killer cell activation
GO:0001649  osteoblast differentiation
GO:0042104  positive regulation of activated T cell proliferation
GO:0032722  positive regulation of chemokine production
GO:0032967  positive regulation of collagen biosynthetic process
GO:0010628  positive regulation of gene expression
GO:0032725  positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0050729  positive regulation of inflammatory response
GO:0032729  positive regulation of interferon-gamma production
GO:0032731  positive regulation of interleukin-1 beta production
GO:0032740  positive regulation of interleukin-17 production
GO:0032757  positive regulation of interleukin-8 production
GO:0032819  positive regulation of natural killer cell proliferation
GO:0043525  positive regulation of neuron apoptosis
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051142  positive regulation of NK T cell proliferation
GO:0032930  positive regulation of superoxide release
GO:0034105  positive regulation of tissue remodeling
GO:0032760  positive regulation of tumor necrosis factor production
GO:0043117  positive regulation of vascular permeability
GO:0030155  regulation of cell adhesion
GO:0009409  response to cold
GO:0055093  response to hyperoxia
GO:0001666  response to hypoxia
GO:0009314  response to radiation
GO:0030431  sleep
GO:0042088  T-helper 1 type immune response
GO:0042092  T-helper 2 type immune response

Cellular Component

GO:0016324  apical plasma membrane
GO:0005829  cytosol
GO:0005576  extracellular region
GO:0005615  extracellular space

Molecular Function

GO:0005125  cytokine activity