insulin receptor substrate 1

詳細情報を見る

同義遺伝子名

IRS-1, IRS1, HIRS-1, insulin receptor substrate 1, Insulin receptor substrate 1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:9.50 小脳:12.60 脳幹:- 脳梁:29.20 松果体:- 末梢神経:30.70 脊柱:- 網膜:118.60 目:11.80 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:25.80 骨髄:- 脂肪:40.30 骨:25.60 皮膚:33.60
GeneChip 大脳:5.07 小脳:6.01 脳幹:5.22 脳梁:4.64 松果体:- 末梢神経:5.42 脊柱:5.09 網膜:- 目:- 動脈:6.14 静脈:6 リンパ節:5.31 末梢血:- 脾臓:5.15 胸腺:6.99 骨髄:4.38 脂肪:6.89 骨:- 皮膚:6.17
CAGE 大脳:1.78 小脳:- 脳幹:1.54 脳梁:1.39 松果体:3.18 末梢神経:- 脊柱:1.86 網膜:- 目:- 動脈:2.50 静脈:2.64 リンパ節:1.87 末梢血:- 脾臓:1.97 胸腺:3.20 骨髄:- 脂肪:2.50 骨:- 皮膚:-
RNA-seq 大脳:1.17 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.75 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.94 骨:- 皮膚:-
EST 子宮:72.90 胎盤:29.10 前立腺:67.60 卵巣:- 精巣:4.30 心臓:12.80 骨格筋:40.20 食道:- 胃:21.20 腸:32.40 結腸:8.50     肝臓:10.60        肺:29.30    膀胱:- 腎臓:20.80 下垂体:- 甲状腺:163.70 副腎:50.80 膵臓:35.60 乳腺:37.20 唾液腺:-
GeneChip 子宮:7.78 胎盤:5.97 前立腺:7.06 卵巣:7.90 精巣:4.02 心臓:6.37 骨格筋:7.63 食道:5.52 胃:5.95 腸:6.24 結腸:5.70 肝臓:7.98 肺:6.01 膀胱:- 腎臓:6.04 下垂体:4.99 甲状腺:8.46 副腎:7.12 膵臓:5.72 乳腺:7.59 唾液腺:4.38
CAGE 子宮:3.32 胎盤:2.97 前立腺:3.20 卵巣:3.44 精巣:1.65 心臓:2.46 骨格筋:3.04 食道:2.22 胃:- 腸:2.60 結腸:2.45     肝臓:3.24    肺:2.34 膀胱:3.04 腎臓:2.34 下垂体:1.68 甲状腺:4.03 副腎:- 膵臓:2.54 乳腺:2.79 唾液腺:1.58
RNA-seq 子宮:- 胎盤:- 前立腺:2.98 卵巣:3.10 精巣:1.38 心臓:1.85 骨格筋:2.40 食道:- 胃:- 腸:- 結腸:2.30     肝臓:1.74        肺:2.23    膀胱:- 腎臓:1.70 下垂体:- 甲状腺:4.35 副腎:1.16 膵臓:- 乳腺:2.78 唾液腺:-

IDs

Refseq ID NM_005544
Gene ID 3667
Unigene ID Hs.471508
Probe set ID 204686_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000169047
GTEx ID ENSG00000169047

オーソログ対応遺伝子

マウス[2]  NM_010570
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0032869  cellular response to insulin stimulus
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0042593  glucose homeostasis
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0016042  lipid catabolic process
GO:0030879  mammary gland development
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0046676  negative regulation of insulin secretion
GO:0048011  nerve growth factor receptor signaling pathway
GO:0014065  phosphoinositide 3-kinase cascade
GO:0048015  phosphoinositide-mediated signaling
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0032000  positive regulation of fatty acid beta-oxidation
GO:0046326  positive regulation of glucose import
GO:0010907  positive regulation of glucose metabolic process
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0046628  positive regulation of insulin receptor signaling pathway
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0043491  protein kinase B signaling cascade
GO:0034504  protein localization in nucleus
GO:0010468  regulation of gene expression
GO:0032868  response to insulin stimulus
GO:0043434  response to peptide hormone stimulus
GO:0007165  signal transduction

Cellular Component

GO:0005901  caveola
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005899  insulin receptor complex
GO:0043231  intracellular membrane-bounded organelle
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0005080  protein kinase C binding
GO:0042169  SH2 domain binding
GO:0004871  signal transducer activity
GO:0005068  transmembrane receptor protein tyrosine kinase adaptor protein activity