Janus kinase 2

詳細情報を見る

同義遺伝子名

JAK-2, Janus kinase 2 (a protein tyrosine kinase), JAK2, Tyrosine-protein kinase JAK2, Janus kinase 2

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST nodata
GeneChip 大脳:5.07 小脳:4.98 脳幹:5.25 脳梁:5.10 松果体:- 末梢神経:5.23 脊柱:5.25 網膜:- 目:- 動脈:5.93 静脈:6.44 リンパ節:5.78 末梢血:- 脾臓:6.06 胸腺:5.39 骨髄:6.70 脂肪:5.58 骨:- 皮膚:5.66
CAGE 大脳:2.73 小脳:- 脳幹:2.73 脳梁:2.57 松果体:3.02 末梢神経:- 脊柱:3.02 網膜:- 目:- 動脈:4.10 静脈:3.17 リンパ節:3.19 末梢血:- 脾臓:3.52 胸腺:2.95 骨髄:- 脂肪:3.32 骨:- 皮膚:-
RNA-seq 大脳:2.16 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.11 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.83 骨:- 皮膚:-
EST nodata
GeneChip 子宮:5.77 胎盤:6.13 前立腺:5.33 卵巣:5.87 精巣:5.27 心臓:5.70 骨格筋:6.49 食道:5.13 胃:5.87 腸:5.51 結腸:4.96 肝臓:4.73 肺:6.07 膀胱:- 腎臓:4.78 下垂体:4.50 甲状腺:4.76 副腎:4.78 膵臓:5.23 乳腺:5.20 唾液腺:4.54
CAGE 子宮:3.31 胎盤:2.67 前立腺:2.99 卵巣:2.91 精巣:3.07 心臓:3.17 骨格筋:3.62 食道:2.98 胃:- 腸:2.97 結腸:2.65     肝臓:1.69    肺:3.38 膀胱:2.86 腎臓:2.43 下垂体:2.47 甲状腺:2.30 副腎:- 膵臓:1.87 乳腺:3.43 唾液腺:2.17
RNA-seq 子宮:- 胎盤:- 前立腺:2.79 卵巣:2.71 精巣:3.24 心臓:3.36 骨格筋:1.72 食道:- 胃:- 腸:- 結腸:2.73     肝臓:0.92        肺:3.08    膀胱:- 腎臓:2.51 下垂体:- 甲状腺:2.19 副腎:3.27 膵臓:- 乳腺:2.57 唾液腺:-

IDs

Refseq ID NM_004972
Gene ID 3717
Unigene ID -
Probe set ID 205842_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000096968
GTEx ID ENSG00000096968

オーソログ対応遺伝子

マウス[4]  NM_001048177, NM_008413
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0030041  actin filament polymerization
GO:0006919  activation of caspase activity
GO:0042977  activation of JAK2 kinase activity
GO:0000186  activation of MAPKK activity
GO:0006915  apoptosis
GO:0031103  axon regeneration
GO:0007596  blood coagulation
GO:0030154  cell differentiation
GO:0006928  cellular component movement
GO:0019221  cytokine-mediated signaling pathway
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007167  enzyme linked receptor protein signaling pathway
GO:0030218  erythrocyte differentiation
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0060396  growth hormone receptor signaling pathway
GO:0009755  hormone-mediated signaling pathway
GO:0008631  induction of apoptosis by oxidative stress
GO:0060333  interferon-gamma-mediated signaling pathway
GO:0007259  JAK-STAT cascade
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0007498  mesoderm development
GO:0031959  mineralocorticoid receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0022408  negative regulation of cell-cell adhesion
GO:0043392  negative regulation of DNA binding
GO:0045822  negative regulation of heart contraction
GO:0043524  negative regulation of neuron apoptosis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0050867  positive regulation of cell activation
GO:0045597  positive regulation of cell differentiation
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0010811  positive regulation of cell-substrate adhesion
GO:0043388  positive regulation of DNA binding
GO:0060399  positive regulation of growth hormone receptor signaling pathway
GO:0050729  positive regulation of inflammatory response
GO:0032024  positive regulation of insulin secretion
GO:0032731  positive regulation of interleukin-1 beta production
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0032516  positive regulation of phosphoprotein phosphatase activity
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0051091  positive regulation of transcription factor activity
GO:0032760  positive regulation of tumor necrosis factor production
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0050727  regulation of inflammatory response
GO:0060334  regulation of interferon-gamma-mediated signaling pathway
GO:0046677  response to antibiotic
GO:0033194  response to hydroperoxide
GO:0070671  response to interleukin-12
GO:0032496  response to lipopolysaccharide
GO:0034612  response to tumor necrosis factor
GO:0007165  signal transduction
GO:0007262  STAT protein nuclear translocation
GO:0033209  tumor necrosis factor-mediated signaling pathway
GO:0007260  tyrosine phosphorylation of STAT protein
GO:0042508  tyrosine phosphorylation of Stat1 protein
GO:0042503  tyrosine phosphorylation of Stat3 protein
GO:0042506  tyrosine phosphorylation of Stat5 protein

Cellular Component

GO:0005901  caveola
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0012505  endomembrane system
GO:0031904  endosome lumen
GO:0045121  membrane raft
GO:0016363  nuclear matrix
GO:0005634  nucleus

Molecular Function

GO:0033130  acetylcholine receptor binding
GO:0005524  ATP binding
GO:0005131  growth hormone receptor binding
GO:0020037  heme binding
GO:0042393  histone binding
GO:0043560  insulin receptor substrate binding
GO:0005143  interleukin-12 receptor binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0051428  peptide hormone receptor binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004713  protein tyrosine kinase activity
GO:0005102  receptor binding
GO:0042169  SH2 domain binding
GO:0031702  type 1 angiotensin receptor binding