kinase insert domain receptor (a type III receptor tyrosine kinase)

 詳細情報を見る

同義遺伝子名

VEGFR-2, FLK1, Protein-tyrosine kinase receptor Flk-1, VEGFR2, KDR, Kinase insert domain receptor, CD309 antigen, CD309, VEGFR

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:32 小脳:12.60 脳幹:- 脳梁:- 松果体:- 末梢神経:122.70 脊柱:112.30 網膜:118.60 目:99.90 動脈:60 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:40.30 骨:12.80 皮膚:33.60
GeneChip 大脳:4.71 小脳:4.17 脳幹:4.93 脳梁:4.71 松果体:- 末梢神経:5.61 脊柱:5.20 網膜:- 目:- 動脈:5.85 静脈:5.71 リンパ節:5.63 末梢血:- 脾臓:5.46 胸腺:4.14 骨髄:4.81 脂肪:6.80 骨:- 皮膚:5.42
CAGE 大脳:1.82 小脳:- 脳幹:2.33 脳梁:2.32 松果体:1.91 末梢神経:- 脊柱:2.11 網膜:- 目:- 動脈:2.59 静脈:2.60 リンパ節:2.53 末梢血:- 脾臓:2.24 胸腺:0.83 骨髄:- 脂肪:3.44 骨:- 皮膚:-
RNA-seq 大脳:1.62 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.77 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:5.16 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:72.90 胎盤:65.60 前立腺:22.50 卵巣:- 精巣:13 心臓:63.90 骨格筋:- 食道:- 胃:- 腸:- 結腸:8.50     肝臓:10.60        肺:63.50    膀胱:- 腎臓:- 下垂体:232 甲状腺:- 副腎:50.80 膵臓:71.10 乳腺:18.60 唾液腺:-
GeneChip 子宮:6.21 胎盤:7.31 前立腺:5.97 卵巣:5.28 精巣:4.34 心臓:6.65 骨格筋:5.20 食道:4.94 胃:5.93 腸:5.66 結腸:5.54 肝臓:6.88 肺:7.49 膀胱:- 腎臓:6.45 下垂体:6.11 甲状腺:7.20 副腎:6.87 膵臓:4.71 乳腺:5.83 唾液腺:5.05
CAGE 子宮:3.68 胎盤:4.09 前立腺:2.98 卵巣:2.54 精巣:2.00 心臓:3.10 骨格筋:2.34 食道:2.39 胃:- 腸:1.84 結腸:2.17     肝臓:2.91    肺:3.44 膀胱:2.15 腎臓:2.71 下垂体:2.39 甲状腺:2.92 副腎:- 膵臓:2.48 乳腺:3.67 唾液腺:2.12
RNA-seq 子宮:- 胎盤:- 前立腺:3.42 卵巣:2.82 精巣:2.98 心臓:3.35 骨格筋:1.79 食道:- 胃:- 腸:- 結腸:3.49     肝臓:3.47        肺:4.44    膀胱:- 腎臓:3.73 下垂体:- 甲状腺:3.63 副腎:4.24 膵臓:- 乳腺:3.76 唾液腺:-

詳細情報

IDs

Refseq ID NM_002253
Gene ID 3791
Unigene ID Hs.479756
Probe set ID 203934_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000128052
GTEx ID ENSG00000128052

オーソログ対応遺伝子

マウス[1]  NM_010612
ラット[1]  NM_010612

染色体

4q12  [55,944,644  -  55,991,756]

遺伝子ファミリー (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain
IPR009134  Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
IPR009136  Tyrosine-protein kinase, vascular endothelial growth factor receptor 2 (VEGFR2)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0048754  branching morphogenesis of a tube
GO:0055074  calcium ion homeostasis
GO:0045165  cell fate commitment
GO:0048469  cell maturation
GO:0002042  cell migration involved in sprouting angiogenesis
GO:0035162  embryonic hemopoiesis
GO:0045446  endothelial cell differentiation
GO:0003158  endothelium development
GO:0048286  lung alveolus development
GO:0001945  lymph vessel development
GO:0043066  negative regulation of apoptosis
GO:0001541  ovarian follicle development
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0051894  positive regulation of focal adhesion formation
GO:0043410  positive regulation of MAPKKK cascade
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0050927  positive regulation of positive chemotaxis
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0046777  protein amino acid autophosphorylation
GO:0008360  regulation of cell shape
GO:0043129  surfactant homeostasis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0001570  vasculogenesis
GO:0019048  virus-host interaction

Cellular Component

GO:0030054  cell junction
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0005769  early endosome
GO:0005768  endosome
GO:0009897  external side of plasma membrane
GO:0005576  extracellular region
GO:0005794  Golgi apparatus
GO:0005887  integral to plasma membrane
GO:0045121  membrane raft
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0051879  Hsp90 protein binding
GO:0005178  integrin binding
GO:0005515  protein binding
GO:0004713  protein tyrosine kinase activity
GO:0004716  receptor signaling protein tyrosine kinase activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0005021  vascular endothelial growth factor receptor activity