lymphocyte-specific protein tyrosine kinase

同義遺伝子名

Proto-oncogene tyrosine-protein kinase LCK, lymphocyte-specific protein tyrosine kinase, p56lck, YT16, LCK, pp58lck, p56-LCK, T cell-specific protein-tyrosine kinase, LSK, Lymphocyte cell-specific protein-tyrosine kinase

正常組織・臓器 40分類
細胞株・初代培養細胞・成体組織・胎児組織 (FANTOM5 CAGE)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:14.20

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:30

静脈:-

リンパ節:444.90

末梢血:400.80

脾臓:529.40

胸腺:2795.80

骨髄:39.40

脂肪:40.30

骨:102.40

皮膚:24

GeneChip

大脳:5.15

小脳:4.97

脳幹:5.20

脳梁:5.05

松果体:-

末梢神経:5.18

脊柱:5.09

網膜:-

目:-

動脈:5.74

静脈:5.51

リンパ節:9.32

末梢血:-

脾臓:9.13

胸腺:11.37

骨髄:6.91

脂肪:6.31

骨:-

皮膚:5.68

CAGE

大脳:0.18

小脳:-

脳幹:0.54

脳梁:0.39

松果体:0.47

末梢神経:-

脊柱:0.46

網膜:-

目:-

動脈:1.22

静脈:4.44

リンパ節:3.99

末梢血:-

脾臓:3.36

胸腺:5.74

骨髄:-

脂肪:0.84

骨:-

皮膚:-

RNA-seq

大脳:0.03

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:5.73

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:0.60

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:18.20

胎盤:3.60

前立腺:11.30

卵巣:37.30

精巣:13

心臓:-

骨格筋:-

食道:-

胃:63.70

腸:97.20

結腸:8.50

肝臓:21.10

肺:24.40

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:50.80

膵臓:17.80

乳腺:9.30

唾液腺:-

GeneChip

子宮:5.42

胎盤:4.72

前立腺:5.66

卵巣:5.41

精巣:5.02

心臓:5.27

骨格筋:5.28

食道:5.49

胃:6.59

腸:6

結腸:6.52

肝臓:6.15

肺:7.08

膀胱:-

腎臓:5.47

下垂体:5.19

甲状腺:5.84

副腎:5.42

膵臓:5.24

乳腺:5.83

唾液腺:5.73

CAGE

子宮:1.37

胎盤:0.64

前立腺:1.61

卵巣:1.13

精巣:0.56

心臓:0.41

骨格筋:0.74

食道:1.81

胃:-

腸:2.54

結腸:2.12

肝臓:1.12

肺:2.48

膀胱:1.66

腎臓:1.03

下垂体:0.19

甲状腺:1.00

副腎:-

膵臓:0

乳腺:0.90

唾液腺:1.82

RNA-seq

子宮:-

胎盤:-

前立腺:0.00

卵巣:0.98

精巣:0.99

心臓:0.00

骨格筋:0.00

食道:-

胃:-

腸:-

結腸:0.00

肝臓:0.00

肺:3.08

膀胱:-

腎臓:0.00

下垂体:-

甲状腺:0.66

副腎:4.33

膵臓:-

乳腺:0.85

唾液腺:-

IDs

Refseq ID	NM_005356
Gene ID	3932
Unigene ID	Hs.470627
Probe set ID	204891_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000182866
GTEx ID	ENSG00000182866

オーソログ対応遺伝子

マウス[3]	NM_001162432, NM_001162433, NM_010693
ラット[1]	NM_001100709, NM_001162433, NM_010693

染色体

1p35.1 [32,716,840 - 32,751,766]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0007568	aging
GO:0050853	B cell receptor signaling pathway
GO:0007596	blood coagulation
GO:0006882	cellular zinc ion homeostasis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0030097	hemopoiesis
GO:0045087	innate immune response
GO:0050900	leukocyte migration
GO:0048011	nerve growth factor receptor signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0048015	phosphoinositide-mediated signaling
GO:0030168	platelet activation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0010628	positive regulation of gene expression
GO:0050870	positive regulation of T cell activation
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0070474	positive regulation of uterine smooth muscle contraction
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0050690	regulation of defense response to virus by virus
GO:0051249	regulation of lymphocyte activation
GO:0051209	release of sequestered calcium ion into cytosol
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0009612	response to mechanical stimulus
GO:0010043	response to zinc ion
GO:0031295	T cell costimulation
GO:0030217	T cell differentiation
GO:0050852	T cell receptor signaling pathway
GO:0016032	viral reproduction
GO:0019048	virus-host interaction

Cellular Component

GO:0005829	cytosol
GO:0030139	endocytic vesicle
GO:0001772	immunological synapse
GO:0045121	membrane raft
GO:0000242	pericentriolar material
GO:0005886	plasma membrane

Molecular Function

GO:0003823	antigen binding
GO:0005524	ATP binding
GO:0051117	ATPase binding
GO:0042609	CD4 receptor binding
GO:0042610	CD8 receptor binding
GO:0001948	glycoprotein binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0043548	phosphoinositide 3-kinase binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0032403	protein complex binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0004722	protein serine/threonine phosphatase activity
GO:0004713	protein tyrosine kinase activity
GO:0042169	SH2 domain binding

lymphocyte-specific protein tyrosine kinase

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function