SMAD family member 4

同義遺伝子名

Mothers against DPP homolog 4, SMAD, mothers against DPP homolog 4 (Drosophila), DPC4, hSMAD4, SMAD-4, MADH4, JIP, Smad-4, SMAD 4, Deletion target in pancreatic carcinoma 4, Mothers against decapentaplegic homolog 4, SMAD4

正常組織・臓器 40分類
細胞株・初代培養細胞・成体組織・胎児組織 (FANTOM5 CAGE)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:77

小脳:138.50

脳幹:-

脳梁:-

松果体:-

末梢神経:153.40

脊柱:224.60

網膜:-

目:41.10

動脈:30

静脈:-

リンパ節:111.20

末梢血:36.40

脾臓:75.60

胸腺:77.30

骨髄:39.40

脂肪:-

骨:25.60

皮膚:120

GeneChip

大脳:4.94

小脳:5.74

脳幹:4.96

脳梁:5.67

松果体:-

末梢神経:6.06

脊柱:5.68

網膜:-

目:-

動脈:5.67

静脈:5.87

リンパ節:5.73

末梢血:-

脾臓:6.34

胸腺:7.41

骨髄:5.89

脂肪:6.13

骨:-

皮膚:5.61

CAGE

大脳:4.16

小脳:-

脳幹:4.04

脳梁:4.27

松果体:4.18

末梢神経:-

脊柱:4.13

網膜:-

目:-

動脈:4.31

静脈:4.33

リンパ節:4.20

末梢血:-

脾臓:4.42

胸腺:4.81

骨髄:-

脂肪:4.64

骨:-

皮膚:-

RNA-seq

大脳:2.88

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:3.45

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:3.57

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:45.60

胎盤:109.30

前立腺:67.60

卵巣:74.50

精巣:69.20

心臓:63.90

骨格筋:100.50

食道:-

胃:127.50

腸:162

結腸:42.40

肝臓:63.30

肺:92.90

膀胱:251.20

腎臓:156

下垂体:116

甲状腺:-

副腎:152.40

膵臓:17.80

乳腺:102.20

唾液腺:328.40

GeneChip

子宮:6.97

胎盤:7.57

前立腺:7.13

卵巣:6.92

精巣:6.39

心臓:6.36

骨格筋:6.31

食道:5.71

胃:6.17

腸:6.41

結腸:5.85

肝臓:5.59

肺:5.97

膀胱:-

腎臓:6.15

下垂体:5.89

甲状腺:6.68

副腎:5.68

膵臓:5.12

乳腺:6.04

唾液腺:6.04

CAGE

子宮:4.74

胎盤:4.68

前立腺:4.70

卵巣:4.75

精巣:4.43

心臓:4.30

骨格筋:4.43

食道:4.43

胃:-

腸:4.49

結腸:4.41

肝臓:4.23

肺:4.51

膀胱:4.72

腎臓:4.27

下垂体:4.83

甲状腺:4.82

副腎:-

膵臓:4.09

乳腺:4.62

唾液腺:4.14

RNA-seq

子宮:-

胎盤:-

前立腺:4.04

卵巣:4.23

精巣:3.80

心臓:3.36

骨格筋:4.38

食道:-

胃:-

腸:-

結腸:3.61

肝臓:2.78

肺:3.57

膀胱:-

腎臓:3.60

下垂体:-

甲状腺:3.95

副腎:3.28

膵臓:-

乳腺:3.76

唾液腺:-

IDs

Refseq ID	NM_005359
Gene ID	4089
Unigene ID	Hs.75862
Probe set ID	202527_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000141646
GTEx ID	ENSG00000141646

オーソログ対応遺伝子

マウス[3]	NM_008540
ラット[1]	NM_019275

染色体

18q21.2 [48,494,410 - 48,611,415]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR003619	MAD homology 1, Dwarfin-type
IPR013019	MAD homology, MH1
IPR001132	SMAD domain, Dwarfin-type
IPR017855	SMAD domain-like
IPR008984	SMAD/FHA domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0003190	atrioventricular valve formation
GO:0007411	axon guidance
GO:0030509	BMP signaling pathway
GO:0003360	brainstem development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0003279	cardiac septum development
GO:0008283	cell proliferation
GO:0048589	developmental growth
GO:0060956	endocardial cell differentiation
GO:0007492	endoderm development
GO:0042118	endothelial cell activation
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0048859	formation of anatomical boundary
GO:0001702	gastrulation with mouth forming second
GO:0010467	gene expression
GO:0001701	in utero embryonic development
GO:0007498	mesoderm development
GO:0060548	negative regulation of cell death
GO:0030308	negative regulation of cell growth
GO:0008285	negative regulation of cell proliferation
GO:0042177	negative regulation of protein catabolic process
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0014033	neural crest cell differentiation
GO:0048663	neuron fate commitment
GO:0060021	palate development
GO:0030513	positive regulation of BMP signaling pathway
GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	positive regulation of SMAD protein nuclear translocation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0051098	regulation of binding
GO:0051797	regulation of hair follicle development
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0032909	regulation of transforming growth factor-beta2 production
GO:0001666	response to hypoxia
GO:0048733	sebaceous gland development
GO:0007183	SMAD protein complex assembly
GO:0060395	SMAD protein signal transduction
GO:0032525	somite rostral/caudal axis specification
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006351	transcription, DNA-dependent
GO:0007179	transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0032444	activin responsive factor complex
GO:0005813	centrosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005730	nucleolus
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0071141	SMAD protein complex
GO:0005667	transcription factor complex

Molecular Function

GO:0003682	chromatin binding
GO:0005518	collagen binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0070411	I-SMAD binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0070412	R-SMAD binding
GO:0043565	sequence-specific DNA binding
GO:0003700	transcription factor activity
GO:0030616	transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

SMAD family member 4

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function