mitogen-activated protein kinase kinase 5

 詳細情報を見る

同義遺伝子名

MAP kinase kinase 5, PRKMK5, MAPKK5, HsT17454, MEK5, mitogen-activated protein kinase kinase 5, MAPK/ERK kinase 5, MAP2K5, MAPKK 5, MKK5

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:53.30 小脳:50.40 脳幹:- 脳梁:116.60 松果体:148.30 末梢神経:30.70 脊柱:224.60 網膜:- 目:70.50 動脈:30 静脈:- リンパ節:40.40 末梢血:109.30 脾臓:37.80 胸腺:103.10 骨髄:255.80 脂肪:80.70 骨:38.40 皮膚:76.80
GeneChip 大脳:5.71 小脳:5.60 脳幹:5.63 脳梁:5.38 松果体:- 末梢神経:6.18 脊柱:5.44 網膜:- 目:- 動脈:5.48 静脈:5.47 リンパ節:5.42 末梢血:- 脾臓:5.39 胸腺:5.61 骨髄:5.06 脂肪:5.49 骨:- 皮膚:5.62
CAGE 大脳:4.04 小脳:- 脳幹:3.53 脳梁:3.81 松果体:4.21 末梢神経:- 脊柱:3.95 網膜:- 目:- 動脈:3.90 静脈:3.89 リンパ節:3.78 末梢血:- 脾臓:3.43 胸腺:4.43 骨髄:- 脂肪:3.60 骨:- 皮膚:-
RNA-seq 大脳:0.31 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.41 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.00 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:45.60 胎盤:51 前立腺:146.40 卵巣:74.50 精巣:90.90 心臓:25.50 骨格筋:- 食道:- 胃:42.50 腸:- 結腸:25.40     肝臓:31.70        肺:19.60    膀胱:- 腎臓:52 下垂体:- 甲状腺:327.50 副腎:101.60 膵臓:- 乳腺:18.60 唾液腺:-
GeneChip 子宮:5.39 胎盤:4.97 前立腺:5.55 卵巣:5.49 精巣:6.41 心臓:5.10 骨格筋:5.83 食道:5.26 胃:5.23 腸:5.36 結腸:5.55 肝臓:4.96 肺:5.53 膀胱:- 腎臓:5.23 下垂体:5.42 甲状腺:5.53 副腎:5.33 膵臓:4.94 乳腺:5.38 唾液腺:5.71
CAGE 子宮:3.70 胎盤:3.09 前立腺:3.56 卵巣:3.67 精巣:3.60 心臓:3.52 骨格筋:3.72 食道:3.20 胃:- 腸:3.19 結腸:3.88     肝臓:3.01    肺:3.48 膀胱:3.64 腎臓:3.15 下垂体:3.57 甲状腺:3.50 副腎:- 膵臓:3.77 乳腺:4.14 唾液腺:3.73
RNA-seq 子宮:- 胎盤:- 前立腺:0.73 卵巣:0.00 精巣:0.00 心臓:0.43 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:1.32     肝臓:0.62        肺:1.02    膀胱:- 腎臓:0.00 下垂体:- 甲状腺:0.00 副腎:1.14 膵臓:- 乳腺:1.11 唾液腺:-

詳細情報

IDs

Refseq ID NM_002757
Gene ID 5607
Unigene ID Hs.114198
Probe set ID 211370_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000137764
GTEx ID ENSG00000137764

オーソログ対応遺伝子

マウス[3]  NM_011840
ラット [0]  

染色体

15q23  [67,835,021  -  68,116,181]

遺伝子ファミリー (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7499418
7759517
8889548
9384584
9790194
10531364
10593883
11073940
11158308
11387209
11520859
12219026
12477932
12618764
12628002
12659851
12813044
12842996
14583600
14702039
14743216
15075238
15378007
15489334
15805119
16728640
16730941
16758967
16861740
17474147
17637780
17872495
18071319
18588859
19223043
19279021
19294699
19605361
19822783
19903815
19913121
20396431
20628086
20935630
20936779
21166929
21767578
21779176
21820407
21861603
21900206
21925394
21988832
22344219
22594783
22939624
23563607
23950888

遺伝子オントロジー  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0070375  BMK cascade
GO:0071363  cellular response to growth factor stimulus
GO:0071499  cellular response to laminar fluid shear stress
GO:0007507  heart development
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0090051  negative regulation of cell migration involved in sprouting angiogenesis
GO:0034115  negative regulation of heterotypic cell-cell adhesion
GO:0045415  negative regulation of interleukin-8 biosynthetic process
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0060761  negative regulation of response to cytokine stimulus
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0048011  nerve growth factor receptor signaling pathway
GO:0030307  positive regulation of cell growth
GO:0050679  positive regulation of epithelial cell proliferation
GO:0051247  positive regulation of protein metabolic process
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0007165  signal transduction

Cellular Component

GO:0005829  cytosol
GO:0005634  nucleus
GO:0005819  spindle

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004713  protein tyrosine kinase activity