presenilin 1

詳細情報を見る

同義遺伝子名

PS1, PSNL1, PS-1, presenilin 1 (Alzheimer disease 3), AD3, PSEN1, S182, Presenilin-1, Protein S182

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST nodata
GeneChip 大脳:6.81 小脳:5.52 脳幹:7.32 脳梁:8.10 松果体:- 末梢神経:6.04 脊柱:7.78 網膜:- 目:- 動脈:5.63 静脈:5.19 リンパ節:5.63 末梢血:- 脾臓:5.42 胸腺:6.03 骨髄:6.06 脂肪:5.84 骨:- 皮膚:6.16
CAGE 大脳:3.80 小脳:- 脳幹:4.38 脳梁:4.96 松果体:3.27 末梢神経:- 脊柱:4.09 網膜:- 目:- 動脈:3.38 静脈:3.25 リンパ節:3.27 末梢血:- 脾臓:3.21 胸腺:3.34 骨髄:- 脂肪:3.46 骨:- 皮膚:-
RNA-seq 大脳:3.27 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.77 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.94 骨:- 皮膚:-
EST nodata
GeneChip 子宮:6.01 胎盤:6.72 前立腺:6.52 卵巣:6 精巣:6.97 心臓:4.98 骨格筋:5.04 食道:6.33 胃:5.49 腸:5.67 結腸:6.03 肝臓:5.13 肺:6.11 膀胱:- 腎臓:5.95 下垂体:5.18 甲状腺:6.01 副腎:5.57 膵臓:4.90 乳腺:6.10 唾液腺:5.80
CAGE 子宮:3.19 胎盤:3.77 前立腺:3.08 卵巣:3.02 精巣:3.58 心臓:3.02 骨格筋:2.84 食道:3.11 胃:- 腸:4.07 結腸:3.64     肝臓:3.17    肺:3.39 膀胱:2.95 腎臓:3.40 下垂体:3.09 甲状腺:3.31 副腎:- 膵臓:3.34 乳腺:2.99 唾液腺:3.09
RNA-seq 子宮:- 胎盤:- 前立腺:2.12 卵巣:2.86 精巣:2.59 心臓:1.29 骨格筋:1.85 食道:- 胃:- 腸:- 結腸:2.19     肝臓:0.69        肺:2.15    膀胱:- 腎臓:2.21 下垂体:- 甲状腺:3.29 副腎:1.80 膵臓:- 乳腺:2.53 唾液腺:-

IDs

Refseq ID NM_000021
Gene ID 5663
Unigene ID -
Probe set ID 203460_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000080815
GTEx ID ENSG00000080815

オーソログ対応遺伝子

マウス[2]  NM_008943
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0042987  amyloid precursor protein catabolic process
GO:0042640  anagen
GO:0000045  autophagic vacuole formation
GO:0034205  beta-amyloid formation
GO:0050435  beta-amyloid metabolic process
GO:0001568  blood vessel development
GO:0048854  brain morphogenesis
GO:0021870  Cajal-Retzius cell differentiation
GO:0070588  calcium ion transmembrane transport
GO:0006816  calcium ion transport
GO:0001708  cell fate specification
GO:0016337  cell-cell adhesion
GO:0021795  cerebral cortex cell migration
GO:0015871  choline transport
GO:0021904  dorsal/ventral neural tube patterning
GO:0030326  embryonic limb morphogenesis
GO:0032469  endoplasmic reticulum calcium ion homeostasis
GO:0050673  epithelial cell proliferation
GO:0001947  heart looping
GO:0002244  hemopoietic progenitor cell differentiation
GO:0015813  L-glutamate transport
GO:0006509  membrane protein ectodomain proteolysis
GO:0007613  memory
GO:0006839  mitochondrial transport
GO:0002573  myeloid leukocyte differentiation
GO:0043066  negative regulation of apoptosis
GO:0050771  negative regulation of axonogenesis
GO:0007175  negative regulation of epidermal growth factor receptor activity
GO:0043524  negative regulation of neuron apoptosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0051444  negative regulation of ubiquitin-protein ligase activity
GO:0051402  neuron apoptosis
GO:0048666  neuron development
GO:0001764  neuron migration
GO:0007220  Notch receptor processing
GO:0007219  Notch signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0043085  positive regulation of catalytic activity
GO:0050820  positive regulation of coagulation
GO:0043406  positive regulation of MAP kinase activity
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001921  positive regulation of receptor recycling
GO:0009791  post-embryonic development
GO:0006486  protein amino acid glycosylation
GO:0016485  protein processing
GO:0015031  protein transport
GO:0042325  regulation of phosphorylation
GO:0043393  regulation of protein binding
GO:0060075  regulation of resting membrane potential
GO:0048167  regulation of synaptic plasticity
GO:0051966  regulation of synaptic transmission, glutamatergic
GO:0006974  response to DNA damage stimulus
GO:0006979  response to oxidative stress
GO:0048705  skeletal system morphogenesis
GO:0043589  skin morphogenesis
GO:0051563  smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756  somitogenesis
GO:0016080  synaptic vesicle targeting
GO:0002286  T cell activation during immune response
GO:0050852  T cell receptor signaling pathway
GO:0048538  thymus development

Cellular Component

GO:0016324  apical plasma membrane
GO:0030424  axon
GO:0005938  cell cortex
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005813  centrosome
GO:0035253  ciliary rootlet
GO:0031410  cytoplasmic vesicle
GO:0043198  dendritic shaft
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0070765  gamma-secretase complex
GO:0005794  Golgi apparatus
GO:0000139  Golgi membrane
GO:0030426  growth cone
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0000776  kinetochore
GO:0005765  lysosomal membrane
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005743  mitochondrial inner membrane
GO:0005739  mitochondrion
GO:0031594  neuromuscular junction
GO:0031965  nuclear membrane
GO:0005640  nuclear outer membrane
GO:0048471  perinuclear region of cytoplasm
GO:0005791  rough endoplasmic reticulum
GO:0005790  smooth endoplasmic reticulum
GO:0030018  Z disc

Molecular Function

GO:0004190  aspartic-type endopeptidase activity
GO:0008013  beta-catenin binding
GO:0045296  cadherin binding
GO:0005262  calcium channel activity
GO:0004175  endopeptidase activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding