phosphatase and tensin homolog

詳細情報を見る

同義遺伝子名

PTEN, TEP1, BZS, Mutated in multiple advanced cancers 1, MMAC1, PTEN1, Phosphatase and tensin homolog, MGC11227, MHAM

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:19 小脳:25.20 脳幹:- 脳梁:58.30 松果体:296.70 末梢神経:122.70 脊柱:- 網膜:118.60 目:58.80 動脈:- 静脈:66.60 リンパ節:242.60 末梢血:18.20 脾臓:18.90 胸腺:103.10 骨髄:59 脂肪:- 骨:25.60 皮膚:72
GeneChip 大脳:5.18 小脳:5.37 脳幹:5.23 脳梁:5.05 松果体:- 末梢神経:6.65 脊柱:5.13 網膜:- 目:- 動脈:6.95 静脈:6.60 リンパ節:6.72 末梢血:- 脾臓:7.24 胸腺:7.93 骨髄:7.47 脂肪:7.55 骨:- 皮膚:6.78
CAGE 大脳:5.10 小脳:- 脳幹:4.75 脳梁:4.44 松果体:5.38 末梢神経:- 脊柱:4.76 網膜:- 目:- 動脈:5.39 静脈:5.44 リンパ節:5.20 末梢血:- 脾臓:5.78 胸腺:5.74 骨髄:- 脂肪:5.82 骨:- 皮膚:-
RNA-seq 大脳:4.09 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:4.60 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:4.96 骨:- 皮膚:-
EST 子宮:72.90 胎盤:43.70 前立腺:78.90 卵巣:37.30 精巣:56.20 心臓:38.30 骨格筋:20.10 食道:- 胃:467.30 腸:- 結腸:110.20     肝臓:84.40        肺:39.10    膀胱:125.60 腎臓:31.20 下垂体:- 甲状腺:163.70 副腎:- 膵臓:17.80 乳腺:65.10 唾液腺:-
GeneChip 子宮:7.17 胎盤:7.53 前立腺:6.81 卵巣:6.69 精巣:7.65 心臓:6.61 骨格筋:4.98 食道:6.66 胃:6.45 腸:6.60 結腸:5.94 肝臓:6.58 肺:6.76 膀胱:- 腎臓:5.38 下垂体:5.58 甲状腺:6.03 副腎:6.41 膵臓:6.96 乳腺:6.39 唾液腺:6.62
CAGE 子宮:5.75 胎盤:5.60 前立腺:5.70 卵巣:5.43 精巣:5.17 心臓:5.11 骨格筋:4.90 食道:5.38 胃:- 腸:5.33 結腸:5.19     肝臓:5.18    肺:5.43 膀胱:5.48 腎臓:5.11 下垂体:5.25 甲状腺:5.24 副腎:- 膵臓:4.73 乳腺:5.64 唾液腺:4.83
RNA-seq 子宮:- 胎盤:- 前立腺:4.57 卵巣:4.79 精巣:4.62 心臓:3.85 骨格筋:3.64 食道:- 胃:- 腸:- 結腸:4.90     肝臓:3.66        肺:4.28    膀胱:- 腎臓:4.65 下垂体:- 甲状腺:4.51 副腎:4.17 膵臓:- 乳腺:4.84 唾液腺:-

IDs

Refseq ID NM_000314
Gene ID 5728
Unigene ID Hs.500466
Probe set ID 217492_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000171862
GTEx ID ENSG00000171862

オーソログ対応遺伝子

マウス[3]  NM_008960
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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24141722
24143235
24149576
24155249
24155657
24156022
24166518
24167614
24168499
24170201
24187456
24221338
24270891
24284390
24317448
24323028
24341335
24344134
24346286
24367090
24380696
24409057
24434152
24462867
24491799
24515759
24556061
24580998
24588644
24595002
24595598
24596386
24599953
24624456
24659669
24685694
24722188
24747746
24768297
24798731
24811168

遺伝子オントロジー  (GO ID)

Biological Process

GO:0007092  activation of anaphase-promoting complex activity during mitotic cell cycle
GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0048854  brain morphogenesis
GO:0048738  cardiac muscle tissue development
GO:0016477  cell migration
GO:0008283  cell proliferation
GO:0007417  central nervous system development
GO:0021955  central nervous system neuron axonogenesis
GO:0021542  dentate gyrus development
GO:0043542  endothelial cell migration
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0048853  forebrain morphogenesis
GO:0007507  heart development
GO:0006917  induction of apoptosis
GO:0045087  innate immune response
GO:0046855  inositol phosphate dephosphorylation
GO:0043647  inositol phosphate metabolic process
GO:0007611  learning or memory
GO:0045475  locomotor rhythm
GO:0007626  locomotory behavior
GO:0060291  long-term synaptic potentiation
GO:0060179  male mating behavior
GO:0042711  maternal behavior
GO:0033555  multicellular organismal response to stress
GO:0032286  myelin maintenance in the central nervous system
GO:0043066  negative regulation of apoptosis
GO:0050771  negative regulation of axonogenesis
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0045792  negative regulation of cell size
GO:0031658  negative regulation of cyclin-dependent protein kinase activity during G1/S
GO:0050680  negative regulation of epithelial cell proliferation
GO:0051895  negative regulation of focal adhesion formation
GO:0031642  negative regulation of myelination
GO:0046621  negative regulation of organ growth
GO:0014067  negative regulation of phosphoinositide 3-kinase cascade
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0090071  negative regulation of ribosome biogenesis
GO:0048011  nerve growth factor receptor signaling pathway
GO:0007270  nerve-nerve synaptic transmission
GO:0006661  phosphatidylinositol biosynthetic process
GO:0046856  phosphoinositide dephosphorylation
GO:0048015  phosphoinositide-mediated signaling
GO:0006644  phospholipid metabolic process
GO:0008284  positive regulation of cell proliferation
GO:0051091  positive regulation of transcription factor activity
GO:0060134  prepulse inhibition
GO:0060736  prostate gland growth
GO:0006470  protein amino acid dephosphorylation
GO:0043491  protein kinase B signaling cascade
GO:0050821  protein stabilization
GO:0002902  regulation of B cell apoptosis
GO:0032535  regulation of cellular component size
GO:0000079  regulation of cyclin-dependent protein kinase activity
GO:0033032  regulation of myeloid cell apoptosis
GO:0010975  regulation of neuron projection development
GO:0031647  regulation of protein stability
GO:0060024  rhythmic synaptic transmission
GO:0035176  social behavior
GO:0007416  synapse assembly
GO:0060074  synapse maturation
GO:0050852  T cell receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0042995  cell projection
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0009898  internal side of plasma membrane
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0016605  PML body
GO:0043220  Schmidt-Lanterman cleft

Molecular Function

GO:0010997  anaphase-promoting complex binding
GO:0019899  enzyme binding
GO:0051717  inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0008289  lipid binding
GO:0000287  magnesium ion binding
GO:0030165  PDZ domain binding
GO:0016314  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800  phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438  phosphatidylinositol-3-phosphatase activity
GO:0004721  phosphoprotein phosphatase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004722  protein serine/threonine phosphatase activity
GO:0004725  protein tyrosine phosphatase activity
GO:0008138  protein tyrosine/serine/threonine phosphatase activity