SHC (Src homology 2 domain containing) transforming protein 1

詳細情報を見る

同義遺伝子名

SHC1, FLJ26504, SHC, p66SHC, p52SHC, SHCA, SHC-transforming protein 1, SH2 domain protein C1, p66

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:88.90 小脳:125.90 脳幹:- 脳梁:729 松果体:- 末梢神経:61.30 脊柱:449.20 網膜:- 目:88.20 動脈:479.60 静脈:266.60 リンパ節:91 末梢血:72.90 脾臓:378.10 胸腺:605.50 骨髄:78.70 脂肪:161.30 骨:371.10 皮膚:360
GeneChip 大脳:6.75 小脳:6.51 脳幹:6.65 脳梁:6.57 松果体:- 末梢神経:8.44 脊柱:7.13 網膜:- 目:- 動脈:9.17 静脈:8.71 リンパ節:8.79 末梢血:- 脾臓:8.48 胸腺:7.83 骨髄:8.09 脂肪:9.24 骨:- 皮膚:8.71
CAGE 大脳:3.09 小脳:- 脳幹:3.10 脳梁:3.02 松果体:3.49 末梢神経:- 脊柱:3.47 網膜:- 目:- 動脈:4.22 静脈:4.01 リンパ節:4.08 末梢血:- 脾臓:4.24 胸腺:3.42 骨髄:- 脂肪:4.33 骨:- 皮膚:-
RNA-seq 大脳:0.59 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.54 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.95 骨:- 皮膚:-
EST 子宮:300.70 胎盤:138.40 前立腺:236.60 卵巣:111.80 精巣:86.50 心臓:166 骨格筋:- 食道:- 胃:42.50 腸:64.80 結腸:50.90     肝臓:63.30        肺:210.20    膀胱:628.10 腎臓:52 下垂体:116 甲状腺:327.50 副腎:101.60 膵臓:8.90 乳腺:148.70 唾液腺:-
GeneChip 子宮:8.93 胎盤:8.67 前立腺:8.66 卵巣:8.76 精巣:7.24 心臓:8.25 骨格筋:7.51 食道:8.54 胃:8.51 腸:8.53 結腸:8.74 肝臓:8.27 肺:8.89 膀胱:- 腎臓:7.87 下垂体:8.62 甲状腺:8.70 副腎:9.15 膵臓:7.75 乳腺:9.21 唾液腺:7.81
CAGE 子宮:4.01 胎盤:4.36 前立腺:4.13 卵巣:4.19 精巣:3.42 心臓:3.88 骨格筋:3.37 食道:4.01 胃:- 腸:4.23 結腸:3.73     肝臓:4.42    肺:3.94 膀胱:4.31 腎臓:3.96 下垂体:3.88 甲状腺:4.15 副腎:- 膵臓:3.69 乳腺:4.24 唾液腺:3.67
RNA-seq 子宮:- 胎盤:- 前立腺:2.37 卵巣:2.49 精巣:0.72 心臓:0.23 骨格筋:0.25 食道:- 胃:- 腸:- 結腸:1.56     肝臓:1.64        肺:1.40    膀胱:- 腎臓:1.81 下垂体:- 甲状腺:1.10 副腎:3.82 膵臓:- 乳腺:1.22 唾液腺:-

IDs

Refseq ID NM_183001
Gene ID 6464
Unigene ID Hs.433795
Probe set ID 214853_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000160691
GTEx ID ENSG00000160691

オーソログ対応遺伝子

マウス[8]  NM_001113331, NM_011368
ラット[2]  NM_001164060, NM_053517

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1623525
7473762
7499194
7506413
7514169
7515480
7516469
7518560
7520523
7524086
7535773
7537361
7537740
7537849
7541035
7541045
7542991
7544002
7544443
7556090
7559478
7559507
7635484
7650013
7657612
7675451
7731718
7739560
7791787
7798267
7806213
7929214
7933095
7953556
7961936
7970715
8035825
8084588
8112292
8125298
8155326
8183561
8195171
8226808
8294403
8400282
8491186
8493579
8524391
8541543
8557643
8577769
8610109
8617812
8621719
8626541
8628261
8631299
8631894
8633037
8643566
8643691
8647288
8656061
8662733
8662748
8662998
8702728
8723348
8761298
8776723
8810325
8874179
8887653
8890167
8918464
8939605
8940017
8940081
8943228
8950973
8995379
9045663
9045692
9047383
9047384
9049300
9058724
9083103
9096689
9121430
9122198
9126968
9129019
9130710
9148935
9174053
9192859
9202037
9209414
9223670
9233773
9234717
9325171
9344843
9346925
9378963
9388490
9434624
9446569
9461587
9488479
9541596
9544989
9614102
9617486
9632636
9659899
9660480
9660833
9685404
9690470
9694850
9710204
9710588
9716598
9733714
9741627
9756944
9804835
9824671
9837978
9856458
9872323
9886492
9927207
10025673
10037694
10049786
10080542
10085134
10086341
10092678
10194451
10224114
10319320
10340378
10382761
10457218
10477722
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10482988
10559276
10570290
10595738
10602027
10623845
10629055
10635327
10650943
10652211
10662798
10675333
10681566
10704825
10708759
10748054
10749680
10764799
10783152
10790433
10803466
10816433
10822173
10891441
10896916
10900203
10921922
10964917
10971656
10996427
11027663
11044453
11071635
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11287610
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11342545
11349134
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11707390
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11773443
11782427
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11854294
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11877420
11884411
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11888936
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11903040
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12009895
12024011
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12052829
12069755
12114320
12135708
12237775
12400011
12419535
12441060
12446583
12446789
12477932
12485888
12522270
12577067
12586295
12589038
12789267
12808090
12871937
12898421
12925710
14530863
14573619
14665640
14676841
14702039
14749389
14764897
14982882
14983012
14990987
15036421
15094067
15226408
15308584
15316024
15470047
15485499
15488758
15489334
15562031
15588985
15592455
15657067
15688026
15705774
15753984
15812354
15888547
15951569
15992607
16034442
16099422
16113100
16135792
16170380
16186108
16189514
16219545
16257509
16273093
16436505
16481327
16487929
16519809
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16756945
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16843263
16934220
17001306
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18504439
18611262
18660489
18840094
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19172738
19229850
19380743
19383602
19531499
19696221
19826412
19828641
19884766
19889638
19889727
20061561
20111892
20226758
20354186
20379614
20534722
20624904
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20667496
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20697350
20739287
20842738
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21264241
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21778425
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21906983
21933910
21983898
22020565
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22561705
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22661506
22974441
23033271
23267066
23277357
23524280
23529764
23535732
23584453
23606925
23689140
23799367
23815759
23832324
23956138
23990909
23993977
24250222
24407288
24797263
24816145
24823637

遺伝子オントロジー  (GO ID)

Biological Process

GO:0031532  actin cytoskeleton reorganization
GO:0000187  activation of MAPK activity
GO:0006987  activation of signaling protein activity involved in unfolded protein response
GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0016337  cell-cell adhesion
GO:0044267  cellular protein metabolic process
GO:0030968  endoplasmic reticulum unfolded protein response
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0007507  heart development
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0050900  leukocyte migration
GO:0000165  MAPKKK cascade
GO:0048011  nerve growth factor receptor signaling pathway
GO:0030168  platelet activation
GO:0008284  positive regulation of cell proliferation
GO:0045740  positive regulation of DNA replication
GO:0007265  Ras protein signal transduction
GO:0007176  regulation of epidermal growth factor receptor activity
GO:0040008  regulation of growth

Cellular Component

GO:0005829  cytosol
GO:0005759  mitochondrial matrix
GO:0005886  plasma membrane
GO:0070435  Shc-EGFR complex

Molecular Function

GO:0046875  ephrin receptor binding
GO:0005154  epidermal growth factor receptor binding
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005168  neurotrophin TRKA receptor binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0004713  protein tyrosine kinase activity
GO:0005068  transmembrane receptor protein tyrosine kinase adaptor protein activity