bone morphogenetic protein 2

詳細情報を見る

同義遺伝子名

bone morphogenetic protein 2, BMP2A, BMP-2A, Bone morphogenetic protein 2 precursor, BMP 2, BMP2, BMP-2

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:3.60 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:30.70 脊柱:- 網膜:- 目:52.90 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:37.80 胸腺:- 骨髄:- 脂肪:- 骨:25.60 皮膚:57.60
GeneChip 大脳:4.88 小脳:4.40 脳幹:4.99 脳梁:5.12 松果体:- 末梢神経:5.19 脊柱:5.24 網膜:- 目:- 動脈:6.34 静脈:6.18 リンパ節:5.66 末梢血:- 脾臓:7.93 胸腺:4.12 骨髄:5.09 脂肪:6.37 骨:- 皮膚:6.40
CAGE 大脳:0.47 小脳:- 脳幹:0.78 脳梁:0.79 松果体:0.36 末梢神経:- 脊柱:0.29 網膜:- 目:- 動脈:1.72 静脈:1.03 リンパ節:0.60 末梢血:- 脾臓:1.48 胸腺:0 骨髄:- 脂肪:1.29 骨:- 皮膚:-
RNA-seq 大脳:1.95 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.40 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.99 骨:- 皮膚:-
EST 子宮:9.10 胎盤:25.50 前立腺:11.30 卵巣:- 精巣:- 心臓:51.10 骨格筋:- 食道:- 胃:21.20 腸:- 結腸:17     肝臓:-        肺:19.60    膀胱:- 腎臓:10.40 下垂体:- 甲状腺:- 副腎:- 膵臓:35.60 乳腺:9.30 唾液腺:-
GeneChip 子宮:5.58 胎盤:4.90 前立腺:5.16 卵巣:4.95 精巣:4.52 心臓:5.67 骨格筋:5.18 食道:6.07 胃:7.58 腸:5.69 結腸:6.62 肝臓:5.84 肺:7.52 膀胱:- 腎臓:5.53 下垂体:5.19 甲状腺:7.52 副腎:5.64 膵臓:5.77 乳腺:5.96 唾液腺:4.19
CAGE 子宮:0.69 胎盤:0.92 前立腺:1.59 卵巣:0.86 精巣:0.21 心臓:0.95 骨格筋:0.40 食道:1.01 胃:- 腸:1.98 結腸:2.10     肝臓:0.71    肺:1.95 膀胱:1.71 腎臓:0.92 下垂体:0.19 甲状腺:1.79 副腎:- 膵臓:1.59 乳腺:0.90 唾液腺:0
RNA-seq 子宮:- 胎盤:- 前立腺:3.54 卵巣:0.67 精巣:1.45 心臓:1.09 骨格筋:0.78 食道:- 胃:- 腸:- 結腸:2.03     肝臓:1.27        肺:3.73    膀胱:- 腎臓:2.01 下垂体:- 甲状腺:2.56 副腎:2.23 膵臓:- 乳腺:2.85 唾液腺:-

IDs

Refseq ID NM_001200
Gene ID 650
Unigene ID Hs.73853
Probe set ID 205290_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000125845
GTEx ID ENSG00000125845

オーソログ対応遺伝子

マウス[1]  NM_007553
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1487246
2004778
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0060128  adrenocorticotropin hormone secreting cell differentiation
GO:0003181  atrioventricular valve morphogenesis
GO:0030509  BMP signaling pathway
GO:0003130  BMP signaling pathway involved in heart induction
GO:0030282  bone mineralization
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0035051  cardiac cell differentiation
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0055007  cardiac muscle cell differentiation
GO:0055008  cardiac muscle tissue morphogenesis
GO:0045165  cell fate commitment
GO:0007267  cell-cell signaling
GO:0071407  cellular response to organic cyclic substance
GO:0002062  chondrocyte differentiation
GO:0009790  embryonic development
GO:0035054  embryonic heart tube anterior/posterior pattern formation
GO:0003203  endocardial cushion morphogenesis
GO:0001837  epithelial to mesenchymal transition
GO:0030198  extracellular matrix organization
GO:0040007  growth
GO:0007507  heart development
GO:0001701  in utero embryonic development
GO:0006954  inflammatory response
GO:0048839  inner ear development
GO:0048762  mesenchymal cell differentiation
GO:0060485  mesenchyme development
GO:0032348  negative regulation of aldosterone biosynthetic process
GO:0051042  negative regulation of calcium-independent cell-cell adhesion
GO:0045786  negative regulation of cell cycle
GO:0008285  negative regulation of cell proliferation
GO:0043569  negative regulation of insulin-like growth factor receptor signaling pathway
GO:0010894  negative regulation of steroid biosynthetic process
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0003308  negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0007219  Notch signaling pathway
GO:0042475  odontogenesis of dentine-containing tooth
GO:0009887  organ morphogenesis
GO:0001649  osteoblast differentiation
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0060039  pericardium development
GO:0043065  positive regulation of apoptosis
GO:0048711  positive regulation of astrocyte differentiation
GO:0030501  positive regulation of bone mineralization
GO:0030335  positive regulation of cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0045600  positive regulation of fat cell differentiation
GO:0010628  positive regulation of gene expression
GO:0043410  positive regulation of MAPKKK cascade
GO:0045666  positive regulation of neuron differentiation
GO:0042482  positive regulation of odontogenesis
GO:0045778  positive regulation of ossification
GO:0045669  positive regulation of osteoblast differentiation
GO:0033690  positive regulation of osteoblast proliferation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010922  positive regulation of phosphatase activity
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0060804  positive regulation of WNT receptor signaling pathway by BMP signaling pathway
GO:0006468  protein amino acid phosphorylation
GO:0031648  protein destabilization
GO:0006029  proteoglycan metabolic process
GO:0042487  regulation of odontogenesis of dentine-containing tooth
GO:0006355  regulation of transcription, DNA-dependent
GO:0001666  response to hypoxia
GO:0001501  skeletal system development
GO:0060395  SMAD protein signal transduction
GO:0021537  telencephalon development
GO:0021978  telencephalon regionalization
GO:0060129  thyroid stimulating hormone secreting cell differentiation

Cellular Component

GO:0009986  cell surface
GO:0005576  extracellular region
GO:0005615  extracellular space

Molecular Function

GO:0070700  BMP receptor binding
GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0019211  phosphatase activator activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0005102  receptor binding
GO:0004745  retinol dehydrogenase activity
GO:0046332  SMAD binding