spleen tyrosine kinase

詳細情報を見る

同義遺伝子名

spleen tyrosine kinase, Spleen tyrosine kinase, SYK, Tyrosine-protein kinase SYK

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:9.50 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:61.30 脊柱:- 網膜:237.30 目:29.40 動脈:- 静脈:- リンパ節:242.60 末梢血:255.10 脾臓:94.50 胸腺:167.50 骨髄:649.50 脂肪:- 骨:64 皮膚:86.40
GeneChip 大脳:5.13 小脳:4.86 脳幹:5.22 脳梁:5.84 松果体:- 末梢神経:5.66 脊柱:5.76 網膜:- 目:- 動脈:5.49 静脈:5.19 リンパ節:7.82 末梢血:- 脾臓:8.49 胸腺:8.02 骨髄:8.47 脂肪:5.94 骨:- 皮膚:6.04
CAGE 大脳:1.90 小脳:- 脳幹:2.62 脳梁:2.74 松果体:0.90 末梢神経:- 脊柱:2.94 網膜:- 目:- 動脈:2.48 静脈:4.08 リンパ節:4.24 末梢血:- 脾臓:4.26 胸腺:3.96 骨髄:- 脂肪:2.81 骨:- 皮膚:-
RNA-seq 大脳:0.00 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.00 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.12 骨:- 皮膚:-
EST 子宮:45.60 胎盤:43.70 前立腺:- 卵巣:- 精巣:38.90 心臓:- 骨格筋:- 食道:- 胃:21.20 腸:64.80 結腸:101.80     肝臓:73.90        肺:68.40    膀胱:125.60 腎臓:31.20 下垂体:- 甲状腺:- 副腎:- 膵臓:8.90 乳腺:18.60 唾液腺:-
GeneChip 子宮:5.48 胎盤:5.33 前立腺:5.40 卵巣:6.26 精巣:5.96 心臓:5.17 骨格筋:5 食道:6.70 胃:6.66 腸:6.32 結腸:6.62 肝臓:5.23 肺:6.79 膀胱:- 腎臓:6.30 下垂体:5.07 甲状腺:8.02 副腎:5.29 膵臓:5.93 乳腺:6.05 唾液腺:6.01
CAGE 子宮:1.91 胎盤:2.37 前立腺:2.28 卵巣:1.79 精巣:2.28 心臓:2.22 骨格筋:0.91 食道:2.87 胃:- 腸:3.44 結腸:3.37     肝臓:1.51    肺:3.33 膀胱:2.21 腎臓:2.41 下垂体:1.54 甲状腺:3.42 副腎:- 膵臓:2.54 乳腺:2.79 唾液腺:2.43
RNA-seq 子宮:- 胎盤:- 前立腺:0.34 卵巣:0 精巣:0.00 心臓:0 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:0.12     肝臓:0        肺:0.00    膀胱:- 腎臓:0.00 下垂体:- 甲状腺:0.00 副腎:0.00 膵臓:- 乳腺:0.00 唾液腺:-

IDs

Refseq ID NM_001135052
Gene ID 6850
Unigene ID Hs.371720
Probe set ID 207540_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000165025
GTEx ID ENSG00000165025

オーソログ対応遺伝子

マウス[3]  NM_001198977, NM_011518
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1423621
1569106
1689310
1998697
2065070
3198621
3350007
3472906
7477352
7500027
7513017
7513161
7538118
7539035
7592872
7600304
7682059
7721825
7761456
7831290
7895172
8071371
8082894
8163536
8168854
8176201
8189062
8197119
8590001
8617742
8621719
8627166
8629002
8630736
8636079
8657103
8666899
8756631
8798764
8885868
8900182
8986718
9096689
9103201
9104825
9120258
9169439
9218456
9268059
9280292
9295288
9342235
9388490
9389695
9490415
9535867
9590210
9590268
9695951
9698567
9710204
9820500
9830044
9846481
9852052
9857068
9880513
9891087
9891970
10022120
10023776
10066823
10072516
10209036
10427990
10449770
10469124
10482988
10540342
10570266
10605028
10617633
10689303
10747947
10748099
10790433
10825200
10862713
10872802
10933389
10940905
10942405
10961871
10963601
10981967
11042121
11046148
11133830
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11162638
11163197
11226282
11262396
11313252
11331248
11356834
11368773
11390470
11418661
11441091
11514608
11536198
11598012
11672534
11676469
11742985
11744621
11782428
11895767
11940607
11964172
11988077
12009018
12051764
12095152
12096713
12209081
12359715
12387735
12393431
12435267
12445683
12447358
12453414
12470302
12477728
12477932
12522270
12682251
12709437
12711606
12771181
12881490
12885943
12907655
14646171
14699155
14702039
15059510
15059847
15062056
15143214
15144186
15163542
15166239
15188513
15337524
15345594
15388330
15467722
15489334
15507431
15536084
15556646
15557085
15577829
15583006
15670211
15701717
15707999
15744341
15754322
15795233
15955106
15956283
16085052
16118313
16273093
16288017
16289966
16291755
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16344560
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16474166
16501050
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16921024
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18005690
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18564921
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18803050
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19122653
19150851
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19195024
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19296913
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19419964
19421152
19435818
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19464057
19477690
19530990
19535334
19549911
19553680
19581935
19738201
19776763
19783684
19800574
19829710
19889729
19893036
19909739
19953087
19965664
20013945
20014315
20068106
20133729
20154219
20201079
20236696
20368800
20379614
20401456
20439541
20439986
20467426
20528870
20563729
20585042
20668539
20705591
20956537
21044950
21047529
21067271
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21086786
21171946
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23039362
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24013589
24023253
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24275652
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24326074
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24447338
24477596
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24523870
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24555683
24564859
24569110
24569586
24583147
24610702
24734927
24779514
24795896
24816145

遺伝子オントロジー  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0002250  adaptive immune response
GO:0001525  angiogenesis
GO:0050853  B cell receptor signaling pathway
GO:0043366  beta selection
GO:0007596  blood coagulation
GO:0048514  blood vessel morphogenesis
GO:0008283  cell proliferation
GO:0071226  cellular response to molecule of fungal origin
GO:0042742  defense response to bacterium
GO:0007167  enzyme linked receptor protein signaling pathway
GO:0045087  innate immune response
GO:0007229  integrin-mediated signaling pathway
GO:0002366  leukocyte activation during immune response
GO:0007159  leukocyte adhesion
GO:0019370  leukotriene biosynthetic process
GO:0001945  lymph vessel development
GO:0002281  macrophage activation during immune response
GO:0002283  neutrophil activation during immune response
GO:0030593  neutrophil chemotaxis
GO:0009887  organ morphogenesis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0030168  platelet activation
GO:0046638  positive regulation of alpha-beta T cell differentiation
GO:0046641  positive regulation of alpha-beta T cell proliferation
GO:0045579  positive regulation of B cell differentiation
GO:0045780  positive regulation of bone resorption
GO:0050850  positive regulation of calcium-mediated signaling
GO:0033630  positive regulation of cell adhesion mediated by integrin
GO:0050715  positive regulation of cytokine secretion
GO:0045588  positive regulation of gamma-delta T cell differentiation
GO:0045425  positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045401  positive regulation of interleukin-3 biosynthetic process
GO:0043306  positive regulation of mast cell degranulation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0043313  regulation of neutrophil degranulation
GO:0050764  regulation of phagocytosis
GO:0010543  regulation of platelet activation
GO:0032928  regulation of superoxide release
GO:0002554  serotonin secretion by platelet
GO:0019048  virus-host interaction

Cellular Component

GO:0019815  B cell receptor complex
GO:0005829  cytosol
GO:0032009  early phagosome
GO:0005886  plasma membrane
GO:0042101  T cell receptor complex

Molecular Function

GO:0005524  ATP binding
GO:0005178  integrin binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004713  protein tyrosine kinase activity
GO:0004716  receptor signaling protein tyrosine kinase activity