ADAM metallopeptidase domain 17

詳細情報を見る

同義遺伝子名

MGC71942, TNF-alpha convertase, CD156b, TACE, cSVP, ADAM17, A disintegrin and metalloproteinase domain 17, CD156B, alpha, ADAM 17 precursor, CSVP, TNF-alpha-converting enzyme, Snake venom-like protease, CD156b antigen

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:14.20 小脳:- 脳幹:- 脳梁:29.20 松果体:- 末梢神経:- 脊柱:- 網膜:118.60 目:35.30 動脈:- 静脈:- リンパ節:30.30 末梢血:- 脾臓:56.70 胸腺:38.70 骨髄:39.40 脂肪:40.30 骨:12.80 皮膚:33.60
GeneChip 大脳:6.26 小脳:5.92 脳幹:6.09 脳梁:6.67 松果体:- 末梢神経:7.08 脊柱:6.68 網膜:- 目:- 動脈:6.62 静脈:6.73 リンパ節:6.84 末梢血:- 脾臓:6.84 胸腺:6.56 骨髄:6.44 脂肪:6.78 骨:- 皮膚:7.24
CAGE 大脳:2.84 小脳:- 脳幹:3.01 脳梁:3.19 松果体:3.19 末梢神経:- 脊柱:3.04 網膜:- 目:- 動脈:3.25 静脈:3.02 リンパ節:3.31 末梢血:- 脾臓:3.56 胸腺:3.08 骨髄:- 脂肪:3.45 骨:- 皮膚:-
RNA-seq 大脳:2.78 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.22 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:4.02 骨:- 皮膚:-
EST 子宮:63.80 胎盤:14.60 前立腺:22.50 卵巣:37.30 精巣:34.60 心臓:- 骨格筋:- 食道:- 胃:127.50 腸:- 結腸:25.40     肝臓:31.70        肺:34.20    膀胱:- 腎臓:20.80 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:65.10 唾液腺:-
GeneChip 子宮:6.74 胎盤:8.01 前立腺:6.46 卵巣:7.04 精巣:7.19 心臓:6.78 骨格筋:5.99 食道:6.95 胃:6.28 腸:6.35 結腸:5.98 肝臓:5.92 肺:7.98 膀胱:- 腎臓:6.03 下垂体:6.07 甲状腺:6.72 副腎:6.65 膵臓:5.36 乳腺:7.39 唾液腺:5.78
CAGE 子宮:3.21 胎盤:3.83 前立腺:2.75 卵巣:3.43 精巣:3.40 心臓:3.16 骨格筋:2.44 食道:3.24 胃:- 腸:2.91 結腸:2.93     肝臓:2.55    肺:3.69 膀胱:3.06 腎臓:3.05 下垂体:2.85 甲状腺:3.00 副腎:- 膵臓:2.76 乳腺:3.33 唾液腺:2.97
RNA-seq 子宮:- 胎盤:- 前立腺:2.69 卵巣:3.54 精巣:3.53 心臓:2.39 骨格筋:2.62 食道:- 胃:- 腸:- 結腸:2.84     肝臓:1.61        肺:3.61    膀胱:- 腎臓:2.67 下垂体:- 甲状腺:3.48 副腎:2.97 膵臓:- 乳腺:3.00 唾液腺:-

IDs

Refseq ID NM_003183
Gene ID 6868
Unigene ID Hs.404914
Probe set ID 213532_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000151694
GTEx ID ENSG00000151694

オーソログ対応遺伝子

マウス[3]  NM_009615
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8889548
9034190
9034191
9520379
9574564
9620803
9774383
9806848
9920899
10224132
10433800
10527948
10799478
10860581
10882063
11733179
11741929
11823465
11988096
12044879
12058067
12135369
12147693
12207026
12441351
12474981
12477932
12535668
12568494
12606576
12621058
12668732
12706122
12711607
12714588
12730960
12743035
12755693
12777399
12810728
12832423
12947092
12972643
14532978
14625290
14970227
15066987
15102849
15146197
15182369
15280379
15308656
15309730
15337756
15534001
15691827
15784625
15983030
16034137
16079149
16148149
16179345
16210695
16246259
16279945
16332693
16336275
16376986
16478662
16619241
16641105
16806063
16900751
16912185
16942750
16982746
17010968
17081983
17155946
17170699
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17360351
17405915
17438092
17608729
17655843
17714581
17786981
17942404
17986144
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18029348
18167350
18171982
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18281553
18355445
18373975
18383040
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18426733
18442814
18483258
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18625725
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18824549
18922903
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19946888
19949420
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20059578
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20221248
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24027752
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24247244
24286866
24337742
24338472
24412389
24518602
24813629

遺伝子オントロジー  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0030183  B cell differentiation
GO:0007155  cell adhesion
GO:0033627  cell adhesion mediated by integrin
GO:0048870  cell motility
GO:0030574  collagen catabolic process
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0022617  extracellular matrix disassembly
GO:0030198  extracellular matrix organization
GO:0002467  germinal center formation
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0006509  membrane protein ectodomain proteolysis
GO:0031293  membrane protein intracellular domain proteolysis
GO:0032717  negative regulation of interleukin-8 production
GO:0048011  nerve growth factor receptor signaling pathway
GO:0002446  neutrophil mediated immunity
GO:0007219  Notch signaling pathway
GO:0051088  PMA-inducible membrane protein ectodomain proteolysis
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0051272  positive regulation of cellular component movement
GO:0032722  positive regulation of chemokine production
GO:0031659  positive regulation of cyclin-dependent protein kinase activity during G1/S
GO:0045741  positive regulation of epidermal growth factor receptor activity
GO:0002690  positive regulation of leukocyte chemotaxis
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0010820  positive regulation of T cell chemotaxis
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033025  regulation of mast cell apoptosis
GO:0042493  response to drug
GO:0055099  response to high density lipoprotein stimulus
GO:0001666  response to hypoxia
GO:0032496  response to lipopolysaccharide
GO:0048536  spleen development
GO:0033077  T cell differentiation in the thymus
GO:0035313  wound healing, spreading of epidermal cells

Cellular Component

GO:0015629  actin cytoskeleton
GO:0016324  apical plasma membrane
GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005925  focal adhesion
GO:0005887  integral to plasma membrane
GO:0045121  membrane raft
GO:0005886  plasma membrane
GO:0032587  ruffle membrane

Molecular Function

GO:0005178  integrin binding
GO:0005138  interleukin-6 receptor binding
GO:0004222  metalloendopeptidase activity
GO:0008237  metallopeptidase activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0017124  SH3 domain binding
GO:0008270  zinc ion binding