transforming growth factor, beta 1

詳細情報を見る

同義遺伝子名

TGFbeta1, TGF beta(1), TGFB, TGF beta1, DPD1, CED, TGFbeta 1, Transforming growth factor beta-1 precursor, TGF beta 1, TGF-beta-1, TGFB1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:- 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:5.31 小脳:4.44 脳幹:5.61 脳梁:5.84 松果体:- 末梢神経:5.80 脊柱:6.17 網膜:- 目:- 動脈:7.05 静脈:6.04 リンパ節:7.92 末梢血:- 脾臓:7.99 胸腺:6.61 骨髄:7.69 脂肪:6.60 骨:- 皮膚:6.31
CAGE 大脳:3.09 小脳:- 脳幹:3.76 脳梁:4.22 松果体:2.78 末梢神経:- 脊柱:3.96 網膜:- 目:- 動脈:4.90 静脈:5.07 リンパ節:5.03 末梢血:- 脾臓:5.47 胸腺:4.78 骨髄:- 脂肪:4.69 骨:- 皮膚:-
RNA-seq 大脳:2.38 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:5.58 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:4.95 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:6.40 胎盤:8.13 前立腺:5.69 卵巣:5.68 精巣:5.22 心臓:5.88 骨格筋:5.13 食道:6.40 胃:6.04 腸:6.25 結腸:6.29 肝臓:5.57 肺:7.64 膀胱:- 腎臓:6 下垂体:5.57 甲状腺:5.59 副腎:6.30 膵臓:5.29 乳腺:6.07 唾液腺:5.08
CAGE 子宮:4.49 胎盤:5.43 前立腺:4.44 卵巣:4.26 精巣:3.72 心臓:4.22 骨格筋:2.42 食道:4.57 胃:- 腸:4.01 結腸:4.06     肝臓:3.70    肺:5.10 膀胱:4.86 腎臓:4.27 下垂体:2.74 甲状腺:3.57 副腎:- 膵臓:3.65 乳腺:4.60 唾液腺:2.88
RNA-seq 子宮:- 胎盤:- 前立腺:4.48 卵巣:4.09 精巣:3.95 心臓:2.57 骨格筋:2.43 食道:- 胃:- 腸:- 結腸:4.01     肝臓:2.34        肺:5.77    膀胱:- 腎臓:3.61 下垂体:- 甲状腺:3.27 副腎:5.07 膵臓:- 乳腺:3.81 唾液腺:-

IDs

Refseq ID NM_000660
Gene ID 7040
Unigene ID Hs.645227
Probe set ID 203085_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105329
GTEx ID ENSG00000105329

オーソログ対応遺伝子

マウス[2]  NM_011577
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0046732  active induction of host immune response by virus
GO:0002460  adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0007568  aging
GO:0006754  ATP biosynthetic process
GO:0007596  blood coagulation
GO:0007050  cell cycle arrest
GO:0016049  cell growth
GO:0045216  cell-cell junction organization
GO:0006874  cellular calcium ion homeostasis
GO:0071407  cellular response to organic cyclic substance
GO:0002062  chondrocyte differentiation
GO:0007182  common-partner SMAD protein phosphorylation
GO:0002248  connective tissue replacement during inflammatory response
GO:0009817  defense response to fungus, incompatible interaction
GO:0009790  embryonic development
GO:0007492  endoderm development
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0001837  epithelial to mesenchymal transition
GO:0019049  evasion of host defenses by virus
GO:0030198  extracellular matrix organization
GO:0060325  face morphogenesis
GO:0007565  female pregnancy
GO:0060364  frontal suture morphogenesis
GO:0008354  germ cell migration
GO:0048565  gut development
GO:0002244  hemopoietic progenitor cell differentiation
GO:0030214  hyaluronan catabolic process
GO:0006954  inflammatory response
GO:0048839  inner ear development
GO:0070306  lens fiber cell differentiation
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0048535  lymph node development
GO:0010742  macrophage derived foam cell differentiation
GO:0060744  mammary gland branching involved in thelarche
GO:0060751  mammary gland duct branch elongation
GO:0000165  MAPKKK cascade
GO:0007093  mitotic cell cycle checkpoint
GO:0032943  mononuclear cell proliferation
GO:0042552  myelination
GO:0043011  myeloid dendritic cell differentiation
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0045786  negative regulation of cell cycle
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0022408  negative regulation of cell-cell adhesion
GO:0008156  negative regulation of DNA replication
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045599  negative regulation of fat cell differentiation
GO:0050777  negative regulation of immune response
GO:0010936  negative regulation of macrophage cytokine production
GO:0045930  negative regulation of mitotic cell cycle
GO:0045662  negative regulation of myoblast differentiation
GO:0007406  negative regulation of neuroblast proliferation
GO:0030279  negative regulation of ossification
GO:0050765  negative regulation of phagocytosis
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0051280  negative regulation of release of sequestered calcium ion into cytosol
GO:0048642  negative regulation of skeletal muscle tissue development
GO:0042130  negative regulation of T cell proliferation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100  organ regeneration
GO:0043932  ossification involved in bone remodeling
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0006796  phosphate metabolic process
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0043065  positive regulation of apoptosis
GO:0043536  positive regulation of blood vessel endothelial cell migration
GO:0030501  positive regulation of bone mineralization
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0071158  positive regulation of cell cycle arrest
GO:0051781  positive regulation of cell division
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0032270  positive regulation of cellular protein metabolic process
GO:0050921  positive regulation of chemotaxis
GO:0032967  positive regulation of collagen biosynthetic process
GO:0050679  positive regulation of epithelial cell proliferation
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0031536  positive regulation of exit from mitosis
GO:0010763  positive regulation of fibroblast migration
GO:0010628  positive regulation of gene expression
GO:0035066  positive regulation of histone acetylation
GO:0031065  positive regulation of histone deacetylation
GO:0032740  positive regulation of interleukin-17 production
GO:0048298  positive regulation of isotype switching to IgA isotypes
GO:0043406  positive regulation of MAP kinase activity
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0042482  positive regulation of odontogenesis
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0010800  positive regulation of peptidyl-threonine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0035307  positive regulation of protein amino acid dephosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0031334  positive regulation of protein complex assembly
GO:0042307  positive regulation of protein import into nucleus
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0050714  positive regulation of protein secretion
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0051152  positive regulation of smooth muscle cell differentiation
GO:0032930  positive regulation of superoxide release
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0010575  positive regulation vascular endothelial growth factor production
GO:0006468  protein amino acid phosphorylation
GO:0006611  protein export from nucleus
GO:0000060  protein import into nucleus, translocation
GO:0043491  protein kinase B signaling cascade
GO:0032801  receptor catabolic process
GO:0051098  regulation of binding
GO:0060762  regulation of branching involved in mammary gland duct morphogenesis
GO:0030334  regulation of cell migration
GO:0051101  regulation of DNA binding
GO:0042306  regulation of protein import into nucleus
GO:0002028  regulation of sodium ion transport
GO:0016202  regulation of striated muscle tissue development
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0045066  regulatory T cell differentiation
GO:0070723  response to cholesterol
GO:0042493  response to drug
GO:0032355  response to estradiol stimulus
GO:0009749  response to glucose stimulus
GO:0001666  response to hypoxia
GO:0034616  response to laminar fluid shear stress
GO:0032570  response to progesterone stimulus
GO:0009314  response to radiation
GO:0033280  response to vitamin D
GO:0009611  response to wounding
GO:0007435  salivary gland morphogenesis
GO:0007183  SMAD protein complex assembly
GO:0007184  SMAD protein nuclear translocation
GO:0043029  T cell homeostasis
GO:0002513  tolerance induction to self antigen
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0001657  ureteric bud development
GO:0019058  viral infectious cycle
GO:0019048  virus-host interaction

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005796  Golgi lumen
GO:0005902  microvillus
GO:0005634  nucleus
GO:0031093  platelet alpha granule lumen
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0019899  enzyme binding
GO:0008083  growth factor activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0047485  protein N-terminus binding
GO:0005114  type II transforming growth factor beta receptor binding