transforming growth factor, beta receptor 1

詳細情報を見る

同義遺伝子名

ALK-5, TGFbeta receptor type I, TGFR-1, ALK5, type I TGFb receptor, type I TGF beta receptor, TGFb receptor type I, Activin receptor-like kinase 5, TGFBR1, AAT5, TGFbRI, Serine/threonine-protein kinase receptor R4, TGFbetaRI, TGFbeta R1, TGF-b receptor type I, TGF-beta receptor type I, TGF-beta receptor type-1 precursor, type I transforming growth factor beta receptor, ACVRLK4, type I TGF-beta receptor, TGF-b type I receptor, TGF beta RI, TGFb type I receptor, TGFbR1, type I TGFbeta receptor, TGF-betaRI, TGF-beta type I receptor, SKR4, TGFbeta type I receptor, TGF beta R1, TGF-beta R1, TGFBRI, type I TGF-b receptor

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:30.80 小脳:37.80 脳幹:- 脳梁:29.20 松果体:- 末梢神経:61.30 脊柱:112.30 網膜:- 目:11.80 動脈:30 静脈:- リンパ節:70.80 末梢血:18.20 脾臓:56.70 胸腺:25.80 骨髄:98.40 脂肪:- 骨:102.40 皮膚:72
GeneChip 大脳:3.55 小脳:3.68 脳幹:3.54 脳梁:3.57 松果体:- 末梢神経:3.68 脊柱:3.70 網膜:- 目:- 動脈:3.76 静脈:3.67 リンパ節:3.59 末梢血:- 脾臓:3.62 胸腺:3.93 骨髄:3.87 脂肪:3.66 骨:- 皮膚:3.63
CAGE 大脳:2.87 小脳:- 脳幹:3.40 脳梁:3.01 松果体:2.85 末梢神経:- 脊柱:3.45 網膜:- 目:- 動脈:4.64 静脈:3.35 リンパ節:3.37 末梢血:- 脾臓:3.27 胸腺:2.73 骨髄:- 脂肪:2.97 骨:- 皮膚:-
RNA-seq 大脳:3.22 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.27 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.88 骨:- 皮膚:-
EST 子宮:100.20 胎盤:98.40 前立腺:45.10 卵巣:74.50 精巣:73.50 心臓:51.10 骨格筋:- 食道:- 胃:- 腸:32.40 結腸:59.40     肝臓:10.60        肺:34.20    膀胱:- 腎臓:104 下垂体:232 甲状腺:- 副腎:50.80 膵臓:35.60 乳腺:65.10 唾液腺:-
GeneChip 子宮:3.61 胎盤:4.19 前立腺:3.58 卵巣:3.54 精巣:3.56 心臓:3.56 骨格筋:3.64 食道:3.58 胃:3.57 腸:3.64 結腸:3.50 肝臓:3.62 肺:3.62 膀胱:- 腎臓:3.63 下垂体:3.77 甲状腺:3.64 副腎:3.49 膵臓:3.64 乳腺:3.55 唾液腺:3.50
CAGE 子宮:3.41 胎盤:4.47 前立腺:3.21 卵巣:3.15 精巣:2.85 心臓:3.31 骨格筋:2.67 食道:3.20 胃:- 腸:2.95 結腸:3.47     肝臓:2.57    肺:3.78 膀胱:3.26 腎臓:3.19 下垂体:3.27 甲状腺:2.49 副腎:- 膵臓:2.81 乳腺:3.62 唾液腺:2.43
RNA-seq 子宮:- 胎盤:- 前立腺:2.48 卵巣:3.71 精巣:2.60 心臓:2.13 骨格筋:1.91 食道:- 胃:- 腸:- 結腸:2.57     肝臓:1.99        肺:3.04    膀胱:- 腎臓:2.58 下垂体:- 甲状腺:2.86 副腎:2.15 膵臓:- 乳腺:3.35 唾液腺:-

IDs

Refseq ID NM_004612
Gene ID 7046
Unigene ID Hs.494622
Probe set ID 206943_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000106799
GTEx ID ENSG00000106799

オーソログ対応遺伝子

マウス[3]  NM_009370
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1319842
1326540
1333888
7518616
7774578
7791754
7852346
7890683
8235612
8242742
8242743
8521960
8530052
8530343
8555189
8576253
8622651
8752209
8774881
8980228
9045666
9136927
9215638
9311995
9335505
9335507
9346894
9346908
9389648
9417915
9435577
9436979
9472030
9525694
9545258
9661882
9738003
9748228
9759503
9774674
9856985
9865696
9872992
9892009
10025408
10085121
10716993
10757800
11100470
11102446
11157754
11163210
11278251
11278302
11279102
11356828
11387212
11420127
11438668
11583628
11746979
11820800
11850637
11867510
12000714
12015308
12017275
12060054
12065756
12082094
12145287
12151385
12202987
12358857
12429842
12446693
12477932
12543979
12607775
12857866
12873459
12947057
14517293
14580334
14597484
14612425
14633705
14657019
14702039
14704634
14718519
14722617
15009106
15102771
15146427
15148321
15155736
15177479
15178549
15221015
15247277
15305380
15317461
15350225
15356634
15359284
15382067
15385056
15459392
15465036
15496141
15498571
15505640
15546867
15599934
15611116
15661740
15702480
15731757
15761148
15761153
15833881
15860866
15863158
15938776
15946939
15955593
15961557
16027725
16289162
16314481
16407286
16428477
16528739
16596670
16754747
16791849
16806156
16835936
16857807
16928994
16947635
16950395
16980081
16998703
17072348
17087113
17099224
17203972
17238135
17314099
17319955
17365852
17507611
17575241
17607123
17649947
17652900
17657819
17703412
17705854
17845732
17848193
17848956
17878231
17890272
17936924
18095342
18097622
18174230
18174246
18202754
18223258
18243111
18252868
18316594
18333754
18421475
18456797
18469808
18474728
18511908
18541723
18546940
18550062
18591668
18625725
18676680
18683732
18703712
18711258
18721526
18758450
18778720
18781618
18781797
18922473
18925687
18974388
18978678
19004027
19012493
19036501
19116361
19139564
19147499
19170196
19214138
19229971
19255252
19258923
19293232
19299112
19299629
19322201
19336370
19375841
19390964
19401691
19426152
19453261
19494318
19505916
19506300
19509225
19538729
19542084
19556242
19586667
19592635
19595713
19601999
19608716
19625176
19626999
19639490
19639654
19672284
19688145
19690145
19692168
19711426
19732720
19736306
19758997
19863607
19882361
19883511
19908237
19913121
19916025
19930569
19936899
19995547
19998449
20052600
20086175
20101143
20101206
20301299
20301312
20354825
20368424
20379614
20403997
20427239
20428796
20429896
20437058
20445748
20453000
20458730
20500843
20503287
20538960
20571025
20587546
20599261
20628086
20634891
20662850
20663871
20675371
20705955
20734064
20924066
20959473
21030067
21068203
21127043
21139048
21170488
21172820
21186301
21224855
21225232
21295082
21304536
21358634
21423151
21429769
21441952
21465483
21478266
21539622
21629263
21677877
21751154
21785915
21791611
21815248
21821041
21858550
21906983
21924348
21962132
21963094
21978186
21987572
22006998
22015652
22078045
22087763
22088447
22096025
22100658
22136666
22278155
22290546
22292045
22314103
22344298
22414221
22473997
22496417
22532183
22610405
22617150
22624557
22651914
22706160
22739178
22773947
22803051
22848678
22905183
22911926
23000965
23027871
23064961
23166821
23349840
23358096
23455636
23548068
23624079
23687300
23734265
23788249
23832740
23874384
23899993
23973329
24103590
24333532
24344132
24347165
24850914

遺伝子オントロジー  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0001525  angiogenesis
GO:0009952  anterior/posterior pattern formation
GO:0006915  apoptosis
GO:0048844  artery morphogenesis
GO:0001824  blastocyst development
GO:0007050  cell cycle arrest
GO:0048870  cell motility
GO:0030199  collagen fibril organization
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0043542  endothelial cell migration
GO:0001837  epithelial to mesenchymal transition
GO:0043062  extracellular structure organization
GO:0008354  germ cell migration
GO:0007507  heart development
GO:0001701  in utero embryonic development
GO:0006917  induction of apoptosis
GO:0001822  kidney development
GO:0002088  lens development in camera-type eye
GO:0048762  mesenchymal cell differentiation
GO:0043066  negative regulation of apoptosis
GO:0032331  negative regulation of chondrocyte differentiation
GO:0001937  negative regulation of endothelial cell proliferation
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048663  neuron fate commitment
GO:0060021  palate development
GO:0060017  parathyroid gland development
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0060037  pharyngeal system development
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0051272  positive regulation of cellular component movement
GO:0051491  positive regulation of filopodium assembly
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0009791  post-embryonic development
GO:0006468  protein amino acid phosphorylation
GO:0043393  regulation of protein binding
GO:0031396  regulation of protein ubiquitination
GO:0006355  regulation of transcription, DNA-dependent
GO:0070723  response to cholesterol
GO:0007165  signal transduction
GO:0001501  skeletal system development
GO:0048705  skeletal system morphogenesis
GO:0048538  thymus development
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0042060  wound healing

Cellular Component

GO:0005886  plasma membrane
GO:0043235  receptor complex
GO:0005923  tight junction
GO:0070022  transforming growth factor beta receptor complex

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0070411  I-SMAD binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0050431  transforming growth factor beta binding
GO:0005024  transforming growth factor beta receptor activity
GO:0005025  transforming growth factor beta receptor activity, type I
GO:0004675  transmembrane receptor protein serine/threonine kinase activity
GO:0005114  type II transforming growth factor beta receptor binding