transforming growth factor, beta receptor II (70/80kDa)

詳細情報を見る

同義遺伝子名

type II TGF-b receptor, TGFBR2, TGF beta RII, TGF-beta type II receptor, TGF-beta R2, TAAD2, AAT3, TGF-b type II receptor, type II transforming growth factor beta receptor, TGFbeta type II receptor, TGFbeta R2, TGFb receptor type II, TGFR-2, TGF-beta RII, TGFBRII, TGFbeta RII, RIIC, TGFbeta receptor type II, HNPCC6, MFS2, TGFbetaRII, type II TGFb receptor, TGF-b receptor type II, FAA3, TGFbRII, TGF beta R2, TGF-beta receptor type-2 precursor, TGFb type II receptor, TGF-beta receptor type II, TGFbeta-RII, type II TGFbeta receptor, type II TGF beta receptor

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:- 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:18.20 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:4.13 小脳:4.28 脳幹:4.18 脳梁:4.27 松果体:- 末梢神経:4.43 脊柱:4.11 網膜:- 目:- 動脈:4.47 静脈:4.68 リンパ節:4.59 末梢血:- 脾臓:4.93 胸腺:4.72 骨髄:4.87 脂肪:5.14 骨:- 皮膚:4.76
CAGE 大脳:3.53 小脳:- 脳幹:4.07 脳梁:4.19 松果体:4.45 末梢神経:- 脊柱:4.38 網膜:- 目:- 動脈:5.92 静脈:5.78 リンパ節:5.65 末梢血:- 脾臓:6.06 胸腺:4.65 骨髄:- 脂肪:6.40 骨:- 皮膚:-
RNA-seq 大脳:1.34 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.49 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:5.41 骨:- 皮膚:-
EST 子宮:- 胎盤:3.60 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:4.50 胎盤:5.04 前立腺:4.33 卵巣:4.53 精巣:3.88 心臓:5 骨格筋:4.50 食道:4.23 胃:4.68 腸:4.99 結腸:4.86 肝臓:4.24 肺:4.61 膀胱:- 腎臓:4.48 下垂体:4.10 甲状腺:4.17 副腎:4.34 膵臓:4.79 乳腺:4.45 唾液腺:4.39
CAGE 子宮:5.61 胎盤:4.68 前立腺:5.47 卵巣:4.96 精巣:4.27 心臓:5.91 骨格筋:4.68 食道:5.45 胃:- 腸:4.92 結腸:5.55     肝臓:4.78    肺:5.99 膀胱:5.72 腎臓:5.29 下垂体:4.18 甲状腺:5.37 副腎:- 膵臓:5.02 乳腺:6.37 唾液腺:4.61
RNA-seq 子宮:- 胎盤:- 前立腺:3.00 卵巣:2.61 精巣:3.38 心臓:4.03 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:3.50     肝臓:1.93        肺:4.10    膀胱:- 腎臓:3.05 下垂体:- 甲状腺:4.13 副腎:5.25 膵臓:- 乳腺:4.61 唾液腺:-

IDs

Refseq ID NM_001024847
Gene ID 7048
Unigene ID Hs.604277
Probe set ID 207334_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000163513
GTEx ID ENSG00000163513

オーソログ対応遺伝子

マウス[4]  NM_009371, NM_029575
ラット[1]  NM_031132, NM_029575

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1310899
1319842
1326540
1333888
1525823
7566156
7632217
7761852
7852346
7890683
7935686
7959019
8020936
8106553
8242742
8317497
8388126
8555189
8576253
8622651
8774881
8812462
8840968
8947046
8973329
9045666
9155023
9169454
9335507
9435577
9590282
9856985
9865696
9872992
9926943
9927040
10092230
10207840
10508522
10716993
10757800
10789724
11100470
11102446
11157754
11158177
11163210
11212236
11251969
11278251
11278302
11279102
11323414
11382746
11387212
11483955
11741970
11744689
11777969
11781097
11820800
11850637
12000714
12015308
12017275
12060054
12077447
12121646
12145287
12174910
12202987
12215842
12421567
12429842
12477932
12479849
12515396
12607775
12729750
12736050
12821554
12825850
12840808
12873459
12915548
12939140
12970754
14582709
14601051
14612425
14704634
14727154
14760070
14976186
15009106
15017149
15102771
15146427
15235604
15305380
15340161
15350299
15356634
15522964
15611116
15647279
15702480
15731757
15735734
15761153
15811425
15824172
15856015
15861007
15942678
15976377
16027248
16108056
16283890
16380996
16388503
16428382
16528739
16530041
16549496
16573164
16673206
16733295
16824508
16835936
16849474
16885183
16928994
16982625
17081983
17086361
17087113
17107667
17112860
17117417
17146441
17187359
17194537
17270239
17319955
17330129
17339425
17365852
17418587
17427197
17456004
17470566
17471240
17560608
17562261
17566598
17634290
17637743
17652900
17653092
17676485
17676583
17680270
17692120
17845732
17875924
17878231
17903302
17950544
17985359
18043895
18053089
18084123
18095113
18097622
18174230
18199825
18202754
18243111
18264665
18334936
18339844
18382895
18398939
18448069
18453574
18514338
18546940
18550062
18591668
18598696
18648910
18683732
18721526
18724388
18781618
18829577
18922473
18941508
19006214
19020727
19088080
19147499
19161338
19193655
19229971
19293232
19299629
19335617
19336370
19339270
19351817
19356148
19366699
19424605
19426152
19434696
19453261
19503063
19533785
19538865
19542084
19548309
19556242
19578796
19601999
19624886
19626999
19639654
19672284
19737884
19758997
19883511
19886734
19888426
19913121
19914962
19916025
19937272
19959123
19996017
20067791
20073064
20079749
20101206
20101701
20139972
20144264
20157331
20165854
20197483
20237496
20301299
20301312
20358619
20374083
20379614
20410122
20428796
20457266
20518838
20565851
20587546
20599261
20621662
20628007
20628086
20634891
20662850
20675371
20701609
20734064
20805453
20840324
20864512
20878063
21098638
21131601
21170488
21172820
21186301
21249319
21270064
21295082
21324918
21352603
21358634
21423151
21454688
21609163
21666718
21701930
21725601
21737283
21757750
21785915
21789464
21791611
21815248
21832049
21855067
21924348
21949851
21978186
21988832
22028617
22072622
22093616
22095581
22259224
22278155
22290546
22310065
22314103
22391627
22399565
22425785
22431140
22539603
22571197
22585622
22617150
22651914
22672900
22683712
22684895
22734312
22739178
22848678
22912877
22964853
22972928
23099432
23157888
23178117
23220853
23228659
23248962
23290524
23312833
23395552
23454766
23535729
23548068
23690952
23726841
23734265
23741361
23750746
23788249
23793025
23883197
23899993
23913824
23951322
23970096
23973329
24034922
24093773
24151081
24284203
24447338
24597762

遺伝子オントロジー  (GO ID)

Biological Process

GO:0032147  activation of protein kinase activity
GO:0007568  aging
GO:0006915  apoptosis
GO:0001568  blood vessel development
GO:0007420  brain development
GO:0060434  bronchus morphogenesis
GO:0051216  cartilage development
GO:0007182  common-partner SMAD protein phosphorylation
GO:0007566  embryo implantation
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0035162  embryonic hemopoiesis
GO:0007369  gastrulation
GO:0048565  gut development
GO:0007507  heart development
GO:0001701  in utero embryonic development
GO:0006917  induction of apoptosis
GO:0002088  lens development in camera-type eye
GO:0060463  lung lobe morphogenesis
GO:0060443  mammary gland morphogenesis
GO:0043011  myeloid dendritic cell differentiation
GO:0060044  negative regulation of cardiac muscle cell proliferation
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100  organ regeneration
GO:0060021  palate development
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0001569  patterning of blood vessels
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0002663  positive regulation of B cell tolerance induction
GO:0008284  positive regulation of cell proliferation
GO:0010634  positive regulation of epithelial cell migration
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0051138  positive regulation of NK T cell differentiation
GO:0043415  positive regulation of skeletal muscle tissue regeneration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0002666  positive regulation of T cell tolerance induction
GO:0002651  positive regulation of tolerance induction to self antigen
GO:0006468  protein amino acid phosphorylation
GO:0006898  receptor-mediated endocytosis
GO:0042127  regulation of cell proliferation
GO:0070723  response to cholesterol
GO:0042493  response to drug
GO:0043627  response to estrogen stimulus
GO:0009749  response to glucose stimulus
GO:0009612  response to mechanical stimulus
GO:0007584  response to nutrient
GO:0007224  smoothened signaling pathway
GO:0060440  trachea formation
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0001570  vasculogenesis
GO:0042060  wound healing

Cellular Component

GO:0005901  caveola
GO:0005829  cytosol
GO:0009897  external side of plasma membrane
GO:0016021  integral to membrane
GO:0005886  plasma membrane
GO:0043235  receptor complex
GO:0070022  transforming growth factor beta receptor complex

Molecular Function

GO:0005524  ATP binding
GO:0005539  glycosaminoglycan binding
GO:0046872  metal ion binding
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0005515  protein binding
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0050431  transforming growth factor beta binding
GO:0005024  transforming growth factor beta receptor activity
GO:0005026  transforming growth factor beta receptor activity, type II
GO:0004675  transmembrane receptor protein serine/threonine kinase activity
GO:0034713  type I transforming growth factor beta receptor binding
GO:0034714  type III transforming growth factor beta receptor binding