toll-like receptor 2

詳細情報を見る

同義遺伝子名

CD282, TIL4, CD282 antigen, toll-like receptor 2, Toll/interleukin 1 receptor-like protein 4, TLR2, Toll-like receptor 2 precursor

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:4.70 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:17.60 動脈:- 静脈:- リンパ節:10.10 末梢血:72.90 脾臓:- 胸腺:25.80 骨髄:177.10 脂肪:- 骨:64 皮膚:-
GeneChip 大脳:4.72 小脳:4.43 脳幹:4.85 脳梁:4.99 松果体:- 末梢神経:5.50 脊柱:5.37 網膜:- 目:- 動脈:5.18 静脈:5.03 リンパ節:5.31 末梢血:- 脾臓:5.58 胸腺:4.73 骨髄:6.33 脂肪:5.15 骨:- 皮膚:5.43
CAGE 大脳:2.02 小脳:- 脳幹:2.64 脳梁:1.93 松果体:1.98 末梢神経:- 脊柱:3.66 網膜:- 目:- 動脈:2.24 静脈:1.65 リンパ節:3.41 末梢血:- 脾臓:3.79 胸腺:1.06 骨髄:- 脂肪:3.29 骨:- 皮膚:-
RNA-seq 大脳:2.31 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.86 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.76 骨:- 皮膚:-
EST 子宮:- 胎盤:7.30 前立腺:22.50 卵巣:74.50 精巣:- 心臓:12.80 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:21.10        肺:92.90    膀胱:125.60 腎臓:41.60 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:46.50 唾液腺:-
GeneChip 子宮:4.89 胎盤:4.84 前立腺:4.93 卵巣:4.90 精巣:4.55 心臓:5.15 骨格筋:4.89 食道:4.70 胃:4.72 腸:5.18 結腸:4.78 肝臓:5.15 肺:5.88 膀胱:- 腎臓:4.70 下垂体:4.66 甲状腺:4.78 副腎:5.04 膵臓:4.85 乳腺:5.10 唾液腺:5.38
CAGE 子宮:1.58 胎盤:2.21 前立腺:2.46 卵巣:2.19 精巣:1.92 心臓:2.31 骨格筋:1.54 食道:1.80 胃:- 腸:1.86 結腸:1.50     肝臓:2.45    肺:3.64 膀胱:2.66 腎臓:2.88 下垂体:2.11 甲状腺:1.90 副腎:- 膵臓:2.18 乳腺:2.64 唾液腺:2.66
RNA-seq 子宮:- 胎盤:- 前立腺:2.18 卵巣:1.46 精巣:1.78 心臓:1.99 骨格筋:0.30 食道:- 胃:- 腸:- 結腸:0.83     肝臓:2.02        肺:4.00    膀胱:- 腎臓:2.85 下垂体:- 甲状腺:1.37 副腎:2.21 膵臓:- 乳腺:1.64 唾液腺:-

IDs

Refseq ID NM_003264
Gene ID 7097
Unigene ID Hs.519033
Probe set ID 204924_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000137462
GTEx ID ENSG00000137462

オーソログ対応遺伝子

マウス[1]  NM_011905
ラット[1]  NM_198769

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0002752  cell surface pattern recognition receptor signaling pathway
GO:0071221  cellular response to bacterial lipopeptide
GO:0071223  cellular response to lipoteichoic acid
GO:0071224  cellular response to peptidoglycan
GO:0042892  chloramphenicol transport
GO:0050830  defense response to Gram-positive bacterium
GO:0042496  detection of diacylated bacterial lipoprotein
GO:0042495  detection of triacylated bacterial lipoprotein
GO:0007252  I-kappaB phosphorylation
GO:0006955  immune response
GO:0052063  induction by symbiont of defense-related host nitric oxide production
GO:0006917  induction of apoptosis
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0044130  negative regulation of growth of symbiont in host
GO:0032695  negative regulation of interleukin-12 production
GO:0032700  negative regulation of interleukin-17 production
GO:0032722  positive regulation of chemokine production
GO:0050715  positive regulation of cytokine secretion
GO:0050729  positive regulation of inflammatory response
GO:0032728  positive regulation of interferon-beta production
GO:0032735  positive regulation of interleukin-12 production
GO:0032741  positive regulation of interleukin-18 production
GO:0032755  positive regulation of interleukin-6 production
GO:0032757  positive regulation of interleukin-8 production
GO:0002687  positive regulation of leukocyte migration
GO:0060907  positive regulation of macrophage cytokine production
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0034123  positive regulation of toll-like receptor signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042535  positive regulation of tumor necrosis factor biosynthetic process
GO:0032760  positive regulation of tumor necrosis factor production
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0002238  response to molecule of fungal origin
GO:0007165  signal transduction
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0009897  external side of plasma membrane
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0042498  diacylated lipoprotein binding
GO:0001875  lipopolysaccharide receptor activity
GO:0070891  lipoteichoic acid binding
GO:0008329  pattern recognition receptor activity
GO:0042834  peptidoglycan binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0004872  receptor activity
GO:0004888  transmembrane receptor activity
GO:0042497  triacylated lipoprotein binding