inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

詳細情報を見る

同義遺伝子名

I-kappa-B kinase gamma, NEMO, IP2, Fip3p, IkB kinase-associated protein 1, NF-kappa-B essential modulator, IKK-gamma, NF-kappa-B essential modifier, IKBKG, IKKAP1, FIP3, incontinentia pigmenti, IP1, IKKG, FIP-3, IkB kinase subunit gamma

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST nodata
GeneChip 大脳:7.18 小脳:7.28 脳幹:7.25 脳梁:7.24 松果体:- 末梢神経:7.15 脊柱:7.23 網膜:- 目:- 動脈:7.20 静脈:7.31 リンパ節:7.32 末梢血:- 脾臓:7.43 胸腺:6.88 骨髄:7.63 脂肪:7.34 骨:- 皮膚:7.04
CAGE 大脳:2.49 小脳:- 脳幹:2.58 脳梁:2.86 松果体:2.15 末梢神経:- 脊柱:2.24 網膜:- 目:- 動脈:2.38 静脈:2.71 リンパ節:2.46 末梢血:- 脾臓:2.54 胸腺:2.44 骨髄:- 脂肪:2.31 骨:- 皮膚:-
RNA-seq 大脳:1.40 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.43 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.99 骨:- 皮膚:-
EST nodata
GeneChip 子宮:6.89 胎盤:7.35 前立腺:6.65 卵巣:6.87 精巣:7.08 心臓:7.10 骨格筋:7.19 食道:7.26 胃:7.17 腸:7.12 結腸:7.38 肝臓:7.54 肺:7.21 膀胱:- 腎臓:7.21 下垂体:7.57 甲状腺:7.15 副腎:7.32 膵臓:7.16 乳腺:7.06 唾液腺:7.11
CAGE 子宮:2.43 胎盤:2.53 前立腺:2.42 卵巣:2.25 精巣:2.34 心臓:2.17 骨格筋:2.02 食道:2.43 胃:- 腸:2.49 結腸:2.47     肝臓:3.17    肺:2.49 膀胱:2.35 腎臓:2.15 下垂体:1.83 甲状腺:2.27 副腎:- 膵臓:2.18 乳腺:2.41 唾液腺:1.95
RNA-seq 子宮:- 胎盤:- 前立腺:2.16 卵巣:1.61 精巣:1.91 心臓:1.15 骨格筋:1.48 食道:- 胃:- 腸:- 結腸:1.66     肝臓:0.20        肺:1.40    膀胱:- 腎臓:1.94 下垂体:- 甲状腺:1.57 副腎:1.75 膵臓:- 乳腺:1.77 唾液腺:-

IDs

Refseq ID NM_001099857
Gene ID 8517
Unigene ID -
Probe set ID 36004_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000073009
GTEx ID ENSG00000073009

オーソログ対応遺伝子

マウス[21]  NM_001136067, NM_001161421, NM_001161422, NM_001161423, NM_001161424, NM_010547, NM_178590
ラット[1]  NM_199103, NM_001161421, NM_001161422, NM_001161423, NM_001161424, NM_010547, NM_178590

染色体

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

9744859
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0001782  B cell homeostasis
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0006955  immune response
GO:0006917  induction of apoptosis
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0007254  JNK cascade
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0032481  positive regulation of type I interferon production
GO:0006974  response to DNA damage stimulus
GO:0009615  response to virus
GO:0051403  stress-activated MAPK cascade
GO:0050852  T cell receptor signaling pathway
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0006351  transcription, DNA-dependent
GO:0019048  virus-host interaction

Cellular Component

GO:0005737  cytoplasm
GO:0044444  cytoplasmic part
GO:0005829  cytosol
GO:0008385  IkappaB kinase complex
GO:0005622  intracellular
GO:0005634  nucleus

Molecular Function

GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0019904  protein domain specific binding
GO:0046982  protein heterodimerization activity
GO:0004871  signal transducer activity