eukaryotic translation initiation factor 2-alpha kinase 3

詳細情報を見る

同義遺伝子名

HsPEK, Pancreatic eIF2-alpha kinase, PRKR-like endoplasmic reticulum kinase, PERK, PEK, EIF2AK3, DKFZp781H1925

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:19 小脳:12.60 脳幹:- 脳梁:29.20 松果体:- 末梢神経:30.70 脊柱:112.30 網膜:- 目:41.10 動脈:- 静脈:66.60 リンパ節:232.50 末梢血:36.40 脾臓:- 胸腺:12.90 骨髄:39.40 脂肪:- 骨:38.40 皮膚:9.60
GeneChip 大脳:5.38 小脳:5.33 脳幹:5.55 脳梁:5.72 松果体:- 末梢神経:6.27 脊柱:5.90 網膜:- 目:- 動脈:6.13 静脈:5.82 リンパ節:6.83 末梢血:- 脾臓:6.61 胸腺:6.40 骨髄:5.87 脂肪:6.14 骨:- 皮膚:6.06
CAGE 大脳:2.58 小脳:- 脳幹:2.75 脳梁:2.63 松果体:2.52 末梢神経:- 脊柱:2.66 網膜:- 目:- 動脈:3.11 静脈:3.06 リンパ節:3.22 末梢血:- 脾臓:3.13 胸腺:2.79 骨髄:- 脂肪:3.31 骨:- 皮膚:-
RNA-seq 大脳:1.75 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.29 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.50 骨:- 皮膚:-
EST 子宮:27.30 胎盤:18.20 前立腺:56.30 卵巣:- 精巣:4.30 心臓:12.80 骨格筋:100.50 食道:- 胃:21.20 腸:64.80 結腸:8.50     肝臓:73.90        肺:63.50    膀胱:- 腎臓:31.20 下垂体:- 甲状腺:163.70 副腎:- 膵臓:62.20 乳腺:9.30 唾液腺:-
GeneChip 子宮:6.76 胎盤:7.32 前立腺:7.92 卵巣:6.48 精巣:5.27 心臓:5.84 骨格筋:5.17 食道:6.25 胃:7.39 腸:6.51 結腸:5.94 肝臓:6.34 肺:6.30 膀胱:- 腎臓:5.31 下垂体:6.87 甲状腺:6.91 副腎:6.72 膵臓:7.55 乳腺:6.67 唾液腺:8.08
CAGE 子宮:3.20 胎盤:3.29 前立腺:3.20 卵巣:2.84 精巣:2.52 心臓:3.01 骨格筋:3.25 食道:2.98 胃:- 腸:3.09 結腸:2.80     肝臓:3.35    肺:3.23 膀胱:3.80 腎臓:3.11 下垂体:3.54 甲状腺:3.23 副腎:- 膵臓:3.85 乳腺:2.91 唾液腺:4.20
RNA-seq 子宮:- 胎盤:- 前立腺:2.98 卵巣:2.80 精巣:2.40 心臓:1.89 骨格筋:2.01 食道:- 胃:- 腸:- 結腸:2.40     肝臓:2.09        肺:2.79    膀胱:- 腎臓:3.34 下垂体:- 甲状腺:2.92 副腎:2.57 膵臓:- 乳腺:2.32 唾液腺:-

遺伝子オントロジー  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0006987  activation of signaling protein activity involved in unfolded protein response
GO:0030282  bone mineralization
GO:0019722  calcium-mediated signaling
GO:0044267  cellular protein metabolic process
GO:0002063  chondrocyte development
GO:0031018  endocrine pancreas development
GO:0007029  endoplasmic reticulum organization
GO:0030968  endoplasmic reticulum unfolded protein response
GO:0006983  ER overload response
GO:0045444  fat cell differentiation
GO:0030073  insulin secretion
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0007595  lactation
GO:0031642  negative regulation of myelination
GO:0017148  negative regulation of translation
GO:0032057  negative regulation of translational initiation in response to stress
GO:0001503  ossification
GO:0032092  positive regulation of protein binding
GO:0009967  positive regulation of signal transduction
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0051260  protein homooligomerization
GO:0019217  regulation of fatty acid metabolic process
GO:0034976  response to endoplasmic reticulum stress
GO:0001501  skeletal system development
GO:0032933  SREBP-mediated signaling pathway
GO:0006412  translation
GO:0006926  virus-infected cell apoptosis

Cellular Component

GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane

Molecular Function

GO:0005524  ATP binding
GO:0004694  eukaryotic translation initiation factor 2alpha kinase activity
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019903  protein phosphatase binding
GO:0004674  protein serine/threonine kinase activity