Rap guanine nucleotide exchange factor (GEF) 2

詳細情報を見る

同義遺伝子名

RAPGEF2, Neural RAP guanine nucleotide exchange protein, Rap guanine nucleotide exchange factor 2, Rap guanine nucleotide exchange factor (GEF) 2, RA-GEF, PDZGEF1, nRap GEP, Rap-GEP, CNrasGEF, Rap GEP, DKFZP586O1422, KIAA0313, PDZ-GEF1, NRAPGEP

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:98.40 小脳:12.60 脳幹:- 脳梁:- 松果体:148.30 末梢神経:30.70 脊柱:112.30 網膜:118.60 目:76.40 動脈:89.90 静脈:133.30 リンパ節:91 末梢血:36.40 脾臓:18.90 胸腺:38.70 骨髄:59 脂肪:- 骨:25.60 皮膚:33.60
GeneChip 大脳:8.52 小脳:8.05 脳幹:8.09 脳梁:8.18 松果体:- 末梢神経:7.69 脊柱:7.91 網膜:- 目:- 動脈:7.56 静脈:7.23 リンパ節:6.67 末梢血:- 脾臓:8.06 胸腺:6.93 骨髄:8.08 脂肪:7.61 骨:- 皮膚:7.40
CAGE 大脳:2.62 小脳:- 脳幹:2.31 脳梁:2.36 松果体:2.03 末梢神経:- 脊柱:1.85 網膜:- 目:- 動脈:1.03 静脈:0.79 リンパ節:0.35 末梢血:- 脾臓:1.88 胸腺:0.23 骨髄:- 脂肪:0.78 骨:- 皮膚:-
RNA-seq 大脳:4.29 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.70 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:3.37 骨:- 皮膚:-
EST 子宮:72.90 胎盤:83.80 前立腺:22.50 卵巣:74.50 精巣:17.30 心臓:63.90 骨格筋:40.20 食道:- 胃:42.50 腸:- 結腸:84.80     肝臓:95        肺:44    膀胱:- 腎臓:62.40 下垂体:116 甲状腺:- 副腎:152.40 膵臓:80 乳腺:120.80 唾液腺:-
GeneChip 子宮:7.59 胎盤:8.36 前立腺:7.75 卵巣:7.39 精巣:6.32 心臓:7.72 骨格筋:7.67 食道:6.83 胃:7.49 腸:7.41 結腸:6.76 肝臓:8.06 肺:7.79 膀胱:- 腎臓:7.49 下垂体:7.65 甲状腺:8.12 副腎:6.78 膵臓:6.58 乳腺:7.41 唾液腺:7.70
CAGE 子宮:0.69 胎盤:1.27 前立腺:0.62 卵巣:0.26 精巣:0.69 心臓:1.59 骨格筋:1.49 食道:0.68 胃:- 腸:0.66 結腸:0.29     肝臓:0.71    肺:1.20 膀胱:0.33 腎臓:0.82 下垂体:1.38 甲状腺:0.79 副腎:- 膵臓:0 乳腺:0.55 唾液腺:0.83
RNA-seq 子宮:- 胎盤:- 前立腺:2.48 卵巣:2.69 精巣:2.79 心臓:3.07 骨格筋:2.67 食道:- 胃:- 腸:- 結腸:2.74     肝臓:2.26        肺:3.53    膀胱:- 腎臓:2.83 下垂体:- 甲状腺:3.25 副腎:2.45 膵臓:- 乳腺:3.42 唾液腺:-

遺伝子オントロジー  (GO ID)

Biological Process

GO:0001568  blood vessel development
GO:0031547  brain-derived neurotrophic factor receptor signaling pathway
GO:0019933  cAMP-mediated signaling
GO:0071320  cellular response to cAMP
GO:0071321  cellular response to cGMP
GO:0021884  forebrain neuron development
GO:0000165  MAPKKK cascade
GO:0008285  negative regulation of cell proliferation
GO:0050774  negative regulation of dendrite morphogenesis
GO:0048022  negative regulation of melanin biosynthetic process
GO:0043950  positive regulation of cAMP-mediated signaling
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0010976  positive regulation of neuron projection development
GO:0045860  positive regulation of protein kinase activity
GO:0032854  positive regulation of Rap GTPase activity
GO:0032320  positive regulation of Ras GTPase activity
GO:0048167  regulation of synaptic plasticity
GO:0007264  small GTPase mediated signal transduction
GO:0021591  ventricular system development

Cellular Component

GO:0043025  cell soma
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005770  late endosome
GO:0016020  membrane
GO:0043005  neuron projection
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0045202  synapse

Molecular Function

GO:0031697  beta-1 adrenergic receptor binding
GO:0005509  calcium ion binding
GO:0030552  cAMP binding
GO:0030553  cGMP binding
GO:0019992  diacylglycerol binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0046582  Rap GTPase activator activity
GO:0017034  Rap guanyl-nucleotide exchange factor activity
GO:0005088  Ras guanyl-nucleotide exchange factor activity
GO:0004871  signal transducer activity
GO:0050699  WW domain binding