cyclin-dependent kinase inhibitor 1A (P21)

詳細情報を見る

同義遺伝子名

mda6, Melanoma differentiation-associated protein, Cdkn1a, p21Cip1, P21, CDK-interacting protein 1, Cdkn1, Cip1, p21WAF, Cyclin-dependent kinase inhibitor 1, Waf1, SDI1, CIP1, CDKI, CAP20, cyclin-dependent kinase inhibitor 1A (P21)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:20.80 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:191.10 脊柱:- 網膜:- 目:15.20 動脈:84.40 静脈:- リンパ節:1231.40 末梢血:201.30 脾臓:118.50 胸腺:39.50 骨髄:564.10 脂肪:- 骨:112.70 皮膚:150.40
GeneChip 大脳:7.68 小脳:8.03 脳幹:- 脳梁:- 松果体:- 末梢神経:9.16 脊柱:8.29 網膜:6.07 目:6.98 動脈:- 静脈:9.57 リンパ節:7.72 末梢血:- 脾臓:7.01 胸腺:- 骨髄:6.79 脂肪:8.56 骨:7.60 皮膚:10.71
CAGE 大脳:3.14 小脳:- 脳幹:3.31 脳梁:- 松果体:- 末梢神経:- 脊柱:4.32 網膜:- 目:- 動脈:4.91 静脈:- リンパ節:4.68 末梢血:- 脾臓:2.49 胸腺:3.40 骨髄:- 脂肪:- 骨:3.89 皮膚:6.44
RNA-seq 大脳:7.17 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:130.90 胎盤:41.40 前立腺:- 卵巣:11.50 精巣:14.80 心臓:- 骨格筋:852.20 食道:- 胃:- 腸:- 結腸:317.20     肝臓:9.10        肺:50.20    膀胱:66.20 腎臓:8.10 下垂体:38.80 甲状腺:562.40 副腎:- 膵臓:46.90 乳腺:97.90 唾液腺:-
GeneChip 子宮:7.36 胎盤:8.95 前立腺:6.75 卵巣:7.73 精巣:7.14 心臓:8.31 骨格筋:8.19 食道:- 胃:10.07 腸:10.22 結腸:- 肝臓:7.81 肺:10.33 膀胱:8.63 腎臓:7.22 下垂体:7.77 甲状腺:- 副腎:8.24 膵臓:8.10 乳腺:8.03 唾液腺:7.55
CAGE 子宮:3.91 胎盤:4.74 前立腺:3.33 卵巣:4.38 精巣:3.41 心臓:- 骨格筋:- 食道:- 胃:6.50 腸:5.68 結腸:5.92     肝臓:2.13    肺:4.39 膀胱:4.75 腎臓:- 下垂体:4.00 甲状腺:- 副腎:3.96 膵臓:4.93 乳腺:3.13 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:3.02 食道:- 胃:- 腸:- 結腸:-     肝臓:4.68        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_007669
Gene ID 12575
Unigene ID Mm.195663
Probe set ID 1421679_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000023067

オーソログ対応遺伝子

ヒト[2]  NM_000389, NM_001220777, NM_001220778, NM_078467
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

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Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0007050  cell cycle arrest
GO:0031668  cellular response to extracellular stimulus
GO:0071479  cellular response to ionizing radiation
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0000082  G1/S transition of mitotic cell cycle
GO:0000086  G2/M transition of mitotic cell cycle
GO:0043066  negative regulation of apoptosis
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0045736  negative regulation of cyclin-dependent protein kinase activity
GO:0010629  negative regulation of gene expression
GO:0042326  negative regulation of phosphorylation
GO:0016310  phosphorylation
GO:0030890  positive regulation of B cell proliferation
GO:0048146  positive regulation of fibroblast proliferation
GO:0043068  positive regulation of programmed cell death
GO:0051726  regulation of cell cycle
GO:0000079  regulation of cyclin-dependent protein kinase activity
GO:0007346  regulation of mitotic cell cycle
GO:0033158  regulation of protein import into nucleus, translocation
GO:0006974  response to DNA damage stimulus
GO:0009411  response to UV

Cellular Component

GO:0000307  cyclin-dependent protein kinase holoenzyme complex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0070557  PCNA-p21 complex

Molecular Function

GO:0030332  cyclin binding
GO:0019912  cyclin-dependent protein kinase activating kinase activity
GO:0004861  cyclin-dependent protein kinase inhibitor activity
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0004860  protein kinase inhibitor activity
GO:0016740  transferase activity