CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

同義遺伝子名

Ii, HLA-DR-GAMMA, DHLAG, Ia-GAMMA, HLADG, Cd74, Ia antigen-associated invariant chain, CLIP, CD74 antigen, MHC class II-associated invariant chain

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:5.20

小脳:-

脳幹:-

脳梁:-

松果体:257.80

末梢神経:-

脊柱:-

網膜:-

目:38

動脈:-

静脈:-

リンパ節:972.10

末梢血:14.40

脾臓:184.30

胸腺:29.60

骨髄:-

脂肪:-

骨:50.10

皮膚:15.80

GeneChip

大脳:6.77

小脳:6.48

脳幹:-

脳梁:-

松果体:-

末梢神経:9.20

脊柱:7.42

網膜:6.35

目:6.86

動脈:-

静脈:6.73

リンパ節:14.09

末梢血:-

脾臓:14.07

胸腺:-

骨髄:11.61

脂肪:11.16

骨:11.39

皮膚:11.08

CAGE

大脳:2.83

小脳:-

脳幹:3.33

脳梁:-

松果体:-

末梢神経:-

脊柱:3.27

網膜:-

目:-

動脈:7.01

静脈:-

リンパ節:9.85

末梢血:-

脾臓:8.15

胸腺:7.80

骨髄:-

脂肪:-

骨:5.64

皮膚:6.73

RNA-seq

大脳:5.01

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:43.60

胎盤:-

前立腺:30.90

卵巣:-

精巣:-

心臓:18.60

骨格筋:71

食道:-

胃:65.50

腸:332.80

結腸:475.80

肝臓:63.40

肺:632.60

膀胱:66.20

腎臓:185.40

下垂体:-

甲状腺:-

副腎:-

膵臓:65.70

乳腺:522.40

唾液腺:755.90

GeneChip

子宮:11.72

胎盤:7.22

前立腺:10.37

卵巣:11.48

精巣:7.71

心臓:10.49

骨格筋:10.33

食道:-

胃:10.53

腸:11.84

結腸:-

肝臓:9.87

肺:13.10

膀胱:11.39

腎臓:10.58

下垂体:9.81

甲状腺:-

副腎:10.78

膵臓:9.66

乳腺:11.81

唾液腺:10.76

CAGE

子宮:6.05

胎盤:3.42

前立腺:5.45

卵巣:6.20

精巣:1.97

心臓:-

骨格筋:-

食道:-

胃:6.51

腸:5.62

結腸:8.55

肝臓:5.50

肺:7.94

膀胱:6.52

腎臓:-

下垂体:5.39

甲状腺:-

副腎:7.13

膵臓:6.23

乳腺:6.91

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:17.11

食道:-

胃:-

腸:-

結腸:-

肝臓:14.65

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_001042605
Gene ID	16149
Unigene ID	Mm.439737
Probe set ID	1425519_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000024610

オーソログ対応遺伝子

ヒト[3]	NM_001025158, NM_001025159, NM_004355
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

遺伝子オントロジー (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0008283	cell proliferation
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0006952	defense response
GO:0006955	immune response
GO:0016064	immunoglobulin mediated immune response
GO:0006886	intracellular protein transport
GO:0043066	negative regulation of apoptosis
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0002906	negative regulation of mature B cell apoptosis
GO:0002792	negative regulation of peptide secretion
GO:0045581	negative regulation of T cell differentiation
GO:0045060	negative thymic T cell selection
GO:0002821	positive regulation of adaptive immune response
GO:0030890	positive regulation of B cell proliferation
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0048146	positive regulation of fibroblast proliferation
GO:0045089	positive regulation of innate immune response
GO:0060907	positive regulation of macrophage cytokine production
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0045582	positive regulation of T cell differentiation
GO:0002830	positive regulation of T-helper 2 type immune response
GO:0045059	positive thymic T cell selection
GO:0001516	prostaglandin biosynthetic process
GO:0006461	protein complex assembly
GO:0007165	signal transduction

Cellular Component

GO:0009986	cell surface
GO:0005783	endoplasmic reticulum
GO:0009897	external side of plasma membrane
GO:0005794	Golgi apparatus
GO:0016021	integral to membrane
GO:0005887	integral to plasma membrane
GO:0005770	late endosome
GO:0005764	lysosome
GO:0016020	membrane
GO:0042613	MHC class II protein complex
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0005773	vacuole

Molecular Function

GO:0001540	beta-amyloid binding
GO:0019955	cytokine binding
GO:0004896	cytokine receptor activity
GO:0042289	MHC class II protein binding
GO:0050998	nitric-oxide synthase binding
GO:0005515	protein binding

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function