insulin receptor substrate 1

詳細情報を見る

同義遺伝子名

IRS-1, Irs-1, Irs1, insulin receptor substrate 1, G972R, Insulin receptor substrate 1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST nodata
GeneChip 大脳:8.38 小脳:9.29 脳幹:- 脳梁:- 松果体:- 末梢神経:7.99 脊柱:8.56 網膜:8.85 目:9.54 動脈:- 静脈:10.76 リンパ節:7.07 末梢血:- 脾臓:7.20 胸腺:- 骨髄:7.14 脂肪:10.46 骨:8.88 皮膚:10.06
CAGE 大脳:1.78 小脳:- 脳幹:1.91 脳梁:- 松果体:- 末梢神経:- 脊柱:2.25 網膜:- 目:- 動脈:2.95 静脈:- リンパ節:0.57 末梢血:- 脾臓:0.86 胸腺:0.67 骨髄:- 脂肪:- 骨:2.19 皮膚:2.68
RNA-seq 大脳:1.00 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST nodata
GeneChip 子宮:10.74 胎盤:6.90 前立腺:10.55 卵巣:11.16 精巣:5.66 心臓:10.53 骨格筋:12.11 食道:- 胃:8.41 腸:7.34 結腸:- 肝臓:9.80 肺:9.32 膀胱:9.26 腎臓:8.89 下垂体:8.30 甲状腺:- 副腎:9.02 膵臓:7.33 乳腺:11.86 唾液腺:8.85
CAGE 子宮:3.04 胎盤:0.74 前立腺:2.76 卵巣:3.29 精巣:0 心臓:- 骨格筋:- 食道:- 胃:0.67 腸:0.58 結腸:1.27     肝臓:2.64    肺:2.08 膀胱:2.02 腎臓:- 下垂体:1.40 甲状腺:- 副腎:1.98 膵臓:0.84 乳腺:3.44 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.34 食道:- 胃:- 腸:- 結腸:-     肝臓:1.98        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_010570
Gene ID 16367
Unigene ID -
Probe set ID 1423104_at  [Mouse430_2]
Ensembl ID ENSMUSG00000055980

オーソログ対応遺伝子

ヒト[1]  NM_005544
ラット [0]  

染色体

-

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1375946
7488102
7526222
7534300
7544789
7629118
7675087
7969452
8048169
8167159
8240352
8448209
8505282
8544845
8626723
8631859
8649419
8876252
8889548
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9399964
9492017
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24177427
24186867
24333417
24451368

遺伝子オントロジー  (GO ID)

Biological Process

GO:0032869  cellular response to insulin stimulus
GO:0008286  insulin receptor signaling pathway
GO:0030073  insulin secretion
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0016042  lipid catabolic process
GO:0030879  mammary gland development
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0046676  negative regulation of insulin secretion
GO:0014065  phosphoinositide 3-kinase cascade
GO:0030335  positive regulation of cell migration
GO:0032000  positive regulation of fatty acid beta-oxidation
GO:0070094  positive regulation of glucagon secretion
GO:0046326  positive regulation of glucose import
GO:0010907  positive regulation of glucose metabolic process
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0046628  positive regulation of insulin receptor signaling pathway
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0042327  positive regulation of phosphorylation
GO:0051291  protein heterooligomerization
GO:0043491  protein kinase B signaling cascade
GO:0034504  protein localization in nucleus
GO:0010468  regulation of gene expression
GO:0031000  response to caffeine
GO:0032868  response to insulin stimulus
GO:0043434  response to peptide hormone stimulus
GO:0007165  signal transduction

Cellular Component

GO:0005901  caveola
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005899  insulin receptor complex
GO:0043231  intracellular membrane-bounded organelle
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0019904  protein domain specific binding
GO:0019901  protein kinase binding
GO:0005080  protein kinase C binding
GO:0042169  SH2 domain binding
GO:0004871  signal transducer activity
GO:0005068  transmembrane receptor protein tyrosine kinase adaptor protein activity