ISL1 transcription factor, LIM/homeodomain

詳細情報を見る

同義遺伝子名

Islet 1, Insulin gene enhancer protein ISL-1, Isl1, Islet-1, ISL1 transcription factor, LIM/homeodomain

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:- 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:5.56 小脳:3.49 脳幹:- 脳梁:- 松果体:- 末梢神経:10.26 脊柱:4.63 網膜:8.57 目:5.08 動脈:- 静脈:4.89 リンパ節:3.64 末梢血:- 脾臓:3.66 胸腺:- 骨髄:3.67 脂肪:3.99 骨:3.81 皮膚:6.03
CAGE 大脳:0 小脳:- 脳幹:1.36 脳梁:- 松果体:- 末梢神経:- 脊柱:0.91 網膜:- 目:- 動脈:0.70 静脈:- リンパ節:0 末梢血:- 脾臓:0 胸腺:1.57 骨髄:- 脂肪:- 骨:0 皮膚:0.97
RNA-seq 大脳:1.27 小脳:1.27 脳幹:1.27 脳梁:1.27 松果体:1.27 末梢神経:1.27 脊柱:1.27 網膜:1.27 目:1.27 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:11.50 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:3.72 胎盤:3.58 前立腺:8.01 卵巣:3.74 精巣:3.84 心臓:3.89 骨格筋:3.42 食道:- 胃:7.44 腸:4.55 結腸:- 肝臓:4.06 肺:3.82 膀胱:6.02 腎臓:3.77 下垂体:6.90 甲状腺:- 副腎:6.96 膵臓:4.58 乳腺:3.71 唾液腺:3.85
CAGE 子宮:0 胎盤:0.19 前立腺:2.19 卵巣:0 精巣:0 心臓:- 骨格筋:- 食道:- 胃:2.85 腸:0.84 結腸:0.41     肝臓:0    肺:0.17 膀胱:1.58 腎臓:- 下垂体:2.18 甲状腺:- 副腎:2.13 膵臓:0.84 乳腺:0.20 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_021459
Gene ID 16392
Unigene ID Mm.422428
Probe set ID 1450723_at  [Mouse430_2]
Ensembl ID ENSMUSG00000042258

オーソログ対応遺伝子

ヒト[1]  NM_002202
ラット [0]  

染色体

-

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0060413  atrial septum morphogenesis
GO:0060913  cardiac cell fate determination
GO:0060379  cardiac muscle cell myoblast differentiation
GO:0003215  cardiac right ventricle morphogenesis
GO:0003203  endocardial cushion morphogenesis
GO:0007507  heart development
GO:0003007  heart morphogenesis
GO:0060384  innervation
GO:0048762  mesenchymal cell differentiation
GO:0007275  multicellular organismal development
GO:0033147  negative regulation of estrogen receptor signaling pathway
GO:0050728  negative regulation of inflammatory response
GO:0043524  negative regulation of neuron apoptosis
GO:0045665  negative regulation of neuron differentiation
GO:0090074  negative regulation of protein homodimerization activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001755  neural crest cell migration
GO:0030182  neuron differentiation
GO:0048663  neuron fate commitment
GO:0048665  neuron fate specification
GO:0003151  outflow tract morphogenesis
GO:0003148  outflow tract septum morphogenesis
GO:0031016  pancreas development
GO:0048936  peripheral nervous system neuron axonogenesis
GO:0060037  pharyngeal system development
GO:0021983  pituitary gland development
GO:0045766  positive regulation of angiogenesis
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0032725  positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032024  positive regulation of insulin secretion
GO:0032729  positive regulation of interferon-gamma production
GO:0032730  positive regulation of interleukin-1 alpha production
GO:0032731  positive regulation of interleukin-1 beta production
GO:0032735  positive regulation of interleukin-12 production
GO:0032755  positive regulation of interleukin-6 production
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032760  positive regulation of tumor necrosis factor production
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0010575  positive regulation vascular endothelial growth factor production
GO:0010468  regulation of gene expression
GO:0003266  regulation of second heart field cardioblast proliferation
GO:0006355  regulation of transcription, DNA-dependent
GO:0031290  retinal ganglion cell axon guidance
GO:0003139  secondary heart field specification
GO:0048880  sensory system development
GO:0021520  spinal cord motor neuron cell fate specification
GO:0021522  spinal cord motor neuron differentiation
GO:0021559  trigeminal nerve development
GO:0055010  ventricular cardiac muscle tissue morphogenesis
GO:0021524  visceral motor neuron differentiation

Cellular Component

GO:0005622  intracellular
GO:0005634  nucleus

Molecular Function

GO:0043425  bHLH transcription factor binding
GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0030331  estrogen receptor binding
GO:0016922  ligand-dependent nuclear receptor binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008270  zinc ion binding