kinase insert domain protein receptor

 詳細情報を見る

同義遺伝子名

VEGFR-2, Krd-1, Kinase NYK, Protein-tyrosine kinase receptor flk-1, VEGF receptor-2, Fetal liver kinase 1, Flk-1, vascular endothelial growth factor receptor- 2, VEGFR2, Flk1, kinase insert domain protein receptor, CD309 antigen, Ly73, Kdr, 6130401C07

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:24.30 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:19.10 脊柱:- 網膜:- 目:30.40 動脈:- 静脈:- リンパ節:- 末梢血:14.40 脾臓:- 胸腺:59.30 骨髄:38.50 脂肪:- 骨:50.10 皮膚:87.10
GeneChip 大脳:6.74 小脳:6.41 脳幹:- 脳梁:- 松果体:- 末梢神経:6.70 脊柱:7 網膜:8.77 目:7.80 動脈:- 静脈:8.84 リンパ節:9.64 末梢血:- 脾臓:8.25 胸腺:- 骨髄:7.52 脂肪:9.26 骨:8.27 皮膚:7.84
CAGE 大脳:1.64 小脳:- 脳幹:2.08 脳梁:- 松果体:- 末梢神経:- 脊柱:1.94 網膜:- 目:- 動脈:4.00 静脈:- リンパ節:3.64 末梢血:- 脾臓:2.24 胸腺:0.95 骨髄:- 脂肪:- 骨:2.72 皮膚:2.45
RNA-seq 大脳:2.07 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:43.60 胎盤:55.20 前立腺:- 卵巣:91.90 精巣:162.60 心臓:55.80 骨格筋:71 食道:- 胃:65.50 腸:- 結腸:-     肝臓:81.50        肺:50.20    膀胱:- 腎臓:48.40 下垂体:77.50 甲状腺:112.50 副腎:- 膵臓:37.50 乳腺:84.90 唾液腺:-
GeneChip 子宮:8.29 胎盤:9.17 前立腺:7.17 卵巣:8.61 精巣:6.43 心臓:9.92 骨格筋:8.33 食道:- 胃:7.76 腸:7.43 結腸:- 肝臓:8.73 肺:11.09 膀胱:7.64 腎臓:8.69 下垂体:8.36 甲状腺:- 副腎:10.46 膵臓:8.49 乳腺:8.76 唾液腺:7.36
CAGE 子宮:2.59 胎盤:3.45 前立腺:1.51 卵巣:3.09 精巣:0 心臓:- 骨格筋:- 食道:- 胃:2.36 腸:2.60 結腸:2.10     肝臓:3.68    肺:4.83 膀胱:2.70 腎臓:- 下垂体:3.02 甲状腺:- 副腎:4.13 膵臓:2.97 乳腺:3.21 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:2.14 食道:- 胃:- 腸:- 結腸:-     肝臓:4.14        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

詳細情報

IDs

Refseq ID NM_010612
Gene ID 16542
Unigene ID Mm.28500
Probe set ID 1449379_at  [Mouse430_2]
Ensembl ID ENSMUSG00000062960

オーソログ対応遺伝子

ヒト[1]  NM_002253
ラット[1]  NM_002253

染色体

-

遺伝子ファミリー (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain
IPR009134  Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
IPR009136  Tyrosine-protein kinase, vascular endothelial growth factor receptor 2 (VEGFR2)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0060837  blood vessel endothelial cell differentiation
GO:0048754  branching morphogenesis of a tube
GO:0055074  calcium ion homeostasis
GO:0030154  cell differentiation
GO:0045165  cell fate commitment
GO:0048469  cell maturation
GO:0016477  cell migration
GO:0002042  cell migration involved in sprouting angiogenesis
GO:0035162  embryonic hemopoiesis
GO:0003157  endocardium development
GO:0045446  endothelial cell differentiation
GO:0003158  endothelium development
GO:0030097  hemopoiesis
GO:0048286  lung alveolus development
GO:0030324  lung development
GO:0001945  lymph vessel development
GO:0007275  multicellular organismal development
GO:0043066  negative regulation of apoptosis
GO:0001541  ovarian follicle development
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0016310  phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0030513  positive regulation of BMP signaling pathway
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0050679  positive regulation of epithelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0051894  positive regulation of focal adhesion formation
GO:0043410  positive regulation of MAPKKK cascade
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0050927  positive regulation of positive chemotaxis
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0030949  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0008360  regulation of cell shape
GO:0001936  regulation of endothelial cell proliferation
GO:0043129  surfactant homeostasis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0001570  vasculogenesis

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0031410  cytoplasmic vesicle
GO:0005769  early endosome
GO:0005768  endosome
GO:0009897  external side of plasma membrane
GO:0005576  extracellular region
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0005178  integrin binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0005021  vascular endothelial growth factor receptor activity