MAD homolog 3 (Drosophila)

同義遺伝子名

Smad 3, mMad3, Madh3, Mothers against decapentaplegic homolog 3, Smad3, MAD homolog 3 (Drosophila), Mothers against DPP homolog 3, Mad3, SMAD 3, AU022421

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:1.70

小脳:36.80

脳幹:-

脳梁:-

松果体:-

末梢神経:19.10

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:12.50

皮膚:-

GeneChip

大脳:6.15

小脳:6.10

脳幹:-

脳梁:-

松果体:-

末梢神経:5.08

脊柱:5.52

網膜:4.82

目:4.75

動脈:-

静脈:5.81

リンパ節:5.98

末梢血:-

脾臓:5.83

胸腺:-

骨髄:6.01

脂肪:5.93

骨:5.28

皮膚:5.15

CAGE

大脳:2.77

小脳:-

脳幹:1.93

脳梁:-

松果体:-

末梢神経:-

脊柱:2.35

網膜:-

目:-

動脈:2.93

静脈:-

リンパ節:2.33

末梢血:-

脾臓:2.54

胸腺:2.99

骨髄:-

脂肪:-

骨:3.21

皮膚:2.82

RNA-seq

大脳:5.88

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:472.90

心臓:-

骨格筋:-

食道:-

胃:-

腸:-

結腸:-

肝臓:-

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

GeneChip

子宮:6.01

胎盤:6.71

前立腺:5.52

卵巣:6.20

精巣:5.33

心臓:5.73

骨格筋:8.54

食道:-

胃:5.68

腸:5.99

結腸:-

肝臓:5.62

肺:6.26

膀胱:6.89

腎臓:6.15

下垂体:6.22

甲状腺:-

副腎:5.07

膵臓:6.12

乳腺:6.73

唾液腺:4.92

CAGE

子宮:3.12

胎盤:2.81

前立腺:2.14

卵巣:3.45

精巣:1.71

心臓:-

骨格筋:-

食道:-

胃:2.26

腸:2.49

結腸:2.92

肝臓:2.60

肺:3.14

膀胱:4.02

腎臓:-

下垂体:2.73

甲状腺:-

副腎:3.35

膵臓:3.64

乳腺:3.66

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:4.67

食道:-

胃:-

腸:-

結腸:-

肝臓:1.96

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_016769
Gene ID	17127
Unigene ID	Mm.73205
Probe set ID	1450472_s_at [Mouse430_2]
Ensembl ID	ENSMUSG00000032402

オーソログ対応遺伝子

ヒト[16]	NM_001145102, NM_001145103, NM_001145104, NM_005902
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR003619	MAD homology 1, Dwarfin-type
IPR013019	MAD homology, MH1
IPR001132	SMAD domain, Dwarfin-type
IPR017855	SMAD domain-like
IPR008984	SMAD/FHA domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0032924	activin receptor signaling pathway
GO:0007050	cell cycle arrest
GO:0045216	cell-cell junction organization
GO:0048589	developmental growth
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048617	embryonic foregut morphogenesis
GO:0009880	embryonic pattern specification
GO:0007492	endoderm development
GO:0019049	evasion of host defenses by virus
GO:0007369	gastrulation
GO:0001947	heart looping
GO:0006955	immune response
GO:0002520	immune system development
GO:0001701	in utero embryonic development
GO:0070306	lens fiber cell differentiation
GO:0001889	liver development
GO:0001707	mesoderm formation
GO:0043066	negative regulation of apoptosis
GO:0030308	negative regulation of cell growth
GO:0008285	negative regulation of cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0045930	negative regulation of mitotic cell cycle
GO:0045668	negative regulation of osteoblast differentiation
GO:0033689	negative regulation of osteoblast proliferation
GO:0001933	negative regulation of protein amino acid phosphorylation
GO:0042177	negative regulation of protein catabolic process
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002076	osteoblast development
GO:0001649	osteoblast differentiation
GO:0048340	paraxial mesoderm morphogenesis
GO:0060039	pericardium development
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0030501	positive regulation of bone mineralization
GO:0030335	positive regulation of cell migration
GO:0032332	positive regulation of chondrocyte differentiation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0051894	positive regulation of focal adhesion formation
GO:0032731	positive regulation of interleukin-1 beta production
GO:0050927	positive regulation of positive chemotaxis
GO:0051496	positive regulation of stress fiber formation
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0032916	positive regulation of transforming growth factor-beta3 production
GO:0050821	protein stabilization
GO:0051098	regulation of binding
GO:0050678	regulation of epithelial cell proliferation
GO:0050776	regulation of immune response
GO:0016202	regulation of striated muscle tissue development
GO:0006355	regulation of transcription, DNA-dependent
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0032909	regulation of transforming growth factor-beta2 production
GO:0001666	response to hypoxia
GO:0001501	skeletal system development
GO:0007183	SMAD protein complex assembly
GO:0001756	somitogenesis
GO:0042110	T cell activation
GO:0030878	thyroid gland development
GO:0006366	transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-dependent
GO:0060290	transdifferentiation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0006810	transport

Cellular Component

GO:0005737	cytoplasm
GO:0005622	intracellular
GO:0005637	nuclear inner membrane
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0071141	SMAD protein complex
GO:0005667	transcription factor complex

Molecular Function

GO:0008013	beta-catenin binding
GO:0003682	chromatin binding
GO:0031490	chromatin DNA binding
GO:0070410	co-SMAD binding
GO:0005518	collagen binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0003690	double-stranded DNA binding
GO:0019899	enzyme binding
GO:0046872	metal ion binding
GO:0019902	phosphatase binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0019901	protein kinase binding
GO:0070412	R-SMAD binding
GO:0043565	sequence-specific DNA binding
GO:0046332	SMAD binding
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding
GO:0005160	transforming growth factor beta receptor binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0043130	ubiquitin binding
GO:0031625	ubiquitin protein ligase binding
GO:0008270	zinc ion binding

MAD homolog 3 (Drosophila)

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function