transforming growth factor, beta 1

 詳細情報を見る

同義遺伝子名

Tgfb-1, Tgfb, TGF-beta1, transforming growth factor, beta 1, Transforming growth factor beta-1 precursor, TGF-beta-1, TGF-beta 1, Tgfb1

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:1.70 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:7.60 動脈:- 静脈:- リンパ節:118.80 末梢血:- 脾臓:65.80 胸腺:19.80 骨髄:38.50 脂肪:- 骨:12.50 皮膚:23.80
GeneChip 大脳:5.34 小脳:5.43 脳幹:- 脳梁:- 松果体:- 末梢神経:5.43 脊柱:5.82 網膜:4.57 目:5.46 動脈:- 静脈:6.84 リンパ節:10.07 末梢血:- 脾臓:10.35 胸腺:- 骨髄:10.30 脂肪:7.50 骨:9.18 皮膚:6.13
CAGE 大脳:1.64 小脳:- 脳幹:1.90 脳梁:- 松果体:- 末梢神経:- 脊柱:1.66 網膜:- 目:- 動脈:3.65 静脈:- リンパ節:5.27 末梢血:- 脾臓:4.85 胸腺:4.33 骨髄:- 脂肪:- 骨:5.05 皮膚:3.69
RNA-seq 大脳:1.51 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:69 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:106.50 食道:- 胃:- 腸:- 結腸:35.20     肝臓:9.10        肺:20.10    膀胱:- 腎臓:- 下垂体:12.90 甲状腺:- 副腎:- 膵臓:9.40 乳腺:49 唾液腺:-
GeneChip 子宮:7.54 胎盤:7.57 前立腺:6.41 卵巣:7.73 精巣:6.83 心臓:8.17 骨格筋:6.60 食道:- 胃:6.43 腸:6.51 結腸:- 肝臓:6.30 肺:8.56 膀胱:7.14 腎臓:6.79 下垂体:5.37 甲状腺:- 副腎:6.81 膵臓:6.16 乳腺:7.22 唾液腺:6.62
CAGE 子宮:3.04 胎盤:3.62 前立腺:1.97 卵巣:3.48 精巣:2.36 心臓:- 骨格筋:- 食道:- 胃:2.73 腸:2.27 結腸:3.10     肝臓:2.62    肺:4.21 膀胱:3.44 腎臓:- 下垂体:2.06 甲状腺:- 副腎:3.73 膵臓:2.66 乳腺:3.26 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:2.30 食道:- 胃:- 腸:- 結腸:-     肝臓:4.39        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

詳細情報

IDs

Refseq ID NM_011577
Gene ID 21803
Unigene ID Mm.248380
Probe set ID 1420653_at  [Mouse430_2]
Ensembl ID ENSMUSG00000002603

オーソログ対応遺伝子

ヒト[2]  NM_000660
ラット [0]  

染色体

-

遺伝子ファミリー (Interpro ID)

IPR001111  Transforming growth factor beta (TGFb), N-terminal
IPR003911  Transforming growth factor beta TGFb
IPR003939  Transforming growth factor, beta 1
IPR016319  Transforming growth factor-beta
IPR015615  Transforming growth factor-beta-related

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0002460  adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0006754  ATP biosynthetic process
GO:0001775  cell activation
GO:0007050  cell cycle arrest
GO:0008219  cell death
GO:0016049  cell growth
GO:0008283  cell proliferation
GO:0045216  cell-cell junction organization
GO:0006874  cellular calcium ion homeostasis
GO:0071363  cellular response to growth factor stimulus
GO:0071407  cellular response to organic cyclic substance
GO:0002062  chondrocyte differentiation
GO:0007182  common-partner SMAD protein phosphorylation
GO:0006952  defense response
GO:0009817  defense response to fungus, incompatible interaction
GO:0007492  endoderm development
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0001837  epithelial to mesenchymal transition
GO:0019049  evasion of host defenses by virus
GO:0008354  germ cell migration
GO:0040007  growth
GO:0002244  hemopoietic progenitor cell differentiation
GO:0030214  hyaluronan catabolic process
GO:0006954  inflammatory response
GO:0070306  lens fiber cell differentiation
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0048535  lymph node development
GO:0060744  mammary gland branching involved in thelarche
GO:0030879  mammary gland development
GO:0060751  mammary gland duct branch elongation
GO:0000165  MAPKKK cascade
GO:0007093  mitotic cell cycle checkpoint
GO:0032943  mononuclear cell proliferation
GO:0001763  morphogenesis of a branching structure
GO:0042552  myelination
GO:0043011  myeloid dendritic cell differentiation
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0045786  negative regulation of cell cycle
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0022408  negative regulation of cell-cell adhesion
GO:0008156  negative regulation of DNA replication
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045599  negative regulation of fat cell differentiation
GO:0050777  negative regulation of immune response
GO:0010936  negative regulation of macrophage cytokine production
GO:0045930  negative regulation of mitotic cell cycle
GO:0045662  negative regulation of myoblast differentiation
GO:0007406  negative regulation of neuroblast proliferation
GO:0030279  negative regulation of ossification
GO:0050765  negative regulation of phagocytosis
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0051280  negative regulation of release of sequestered calcium ion into cytosol
GO:0048642  negative regulation of skeletal muscle tissue development
GO:0050868  negative regulation of T cell activation
GO:0042130  negative regulation of T cell proliferation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0009887  organ morphogenesis
GO:0031100  organ regeneration
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0006796  phosphate metabolic process
GO:0043065  positive regulation of apoptosis
GO:0043536  positive regulation of blood vessel endothelial cell migration
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0071158  positive regulation of cell cycle arrest
GO:0051781  positive regulation of cell division
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0032270  positive regulation of cellular protein metabolic process
GO:0050921  positive regulation of chemotaxis
GO:0032967  positive regulation of collagen biosynthetic process
GO:0050679  positive regulation of epithelial cell proliferation
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0031536  positive regulation of exit from mitosis
GO:0010763  positive regulation of fibroblast migration
GO:0010628  positive regulation of gene expression
GO:0035066  positive regulation of histone acetylation
GO:0031065  positive regulation of histone deacetylation
GO:0032740  positive regulation of interleukin-17 production
GO:0048298  positive regulation of isotype switching to IgA isotypes
GO:0043406  positive regulation of MAP kinase activity
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0042482  positive regulation of odontogenesis
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0010800  positive regulation of peptidyl-threonine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0035307  positive regulation of protein amino acid dephosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0031334  positive regulation of protein complex assembly
GO:0042307  positive regulation of protein import into nucleus
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0050714  positive regulation of protein secretion
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0051152  positive regulation of smooth muscle cell differentiation
GO:0032930  positive regulation of superoxide release
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0006611  protein export from nucleus
GO:0000060  protein import into nucleus, translocation
GO:0043491  protein kinase B signaling cascade
GO:0032801  receptor catabolic process
GO:0051098  regulation of binding
GO:0060762  regulation of branching involved in mammary gland duct morphogenesis
GO:0042127  regulation of cell proliferation
GO:0051101  regulation of DNA binding
GO:0042306  regulation of protein import into nucleus
GO:0002028  regulation of sodium ion transport
GO:0016202  regulation of striated muscle tissue development
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0045066  regulatory T cell differentiation
GO:0070723  response to cholesterol
GO:0032355  response to estradiol stimulus
GO:0010033  response to organic substance
GO:0032570  response to progesterone stimulus
GO:0007519  skeletal muscle tissue development
GO:0001501  skeletal system development
GO:0007183  SMAD protein complex assembly
GO:0007184  SMAD protein nuclear translocation
GO:0042110  T cell activation
GO:0030217  T cell differentiation
GO:0043029  T cell homeostasis
GO:0002513  tolerance induction to self antigen
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0042060  wound healing

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005902  microvillus
GO:0005634  nucleus
GO:0005578  proteinaceous extracellular matrix
GO:0030141  secretory granule

Molecular Function

GO:0019899  enzyme binding
GO:0008083  growth factor activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0047485  protein N-terminus binding
GO:0005160  transforming growth factor beta receptor binding
GO:0005114  type II transforming growth factor beta receptor binding