transforming growth factor, beta receptor I

詳細情報を見る

同義遺伝子名

TGF-beta receptor type-1 precursor, Alk-5, AU017191, TGF-beta type I receptor, Tgfbr1, TbetaRI, transforming growth factor, beta receptor I, TGF-beta receptor type I, ESK2, TGFR-1, ALK5, TbetaR-I

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:109.40 小脳:36.80 脳幹:- 脳梁:- 松果体:- 末梢神経:57.30 脊柱:- 網膜:128.60 目:174.80 動脈:84.40 静脈:- リンパ節:194.40 末梢血:71.90 脾臓:79 胸腺:49.40 骨髄:- 脂肪:- 骨:62.60 皮膚:31.70
GeneChip 大脳:4.86 小脳:4.57 脳幹:- 脳梁:- 松果体:- 末梢神経:4.80 脊柱:4.83 網膜:4.31 目:4.55 動脈:- 静脈:7.43 リンパ節:6.18 末梢血:- 脾臓:5.99 胸腺:- 骨髄:5.76 脂肪:5.55 骨:5.37 皮膚:4.91
CAGE 大脳:1.69 小脳:- 脳幹:2.04 脳梁:- 松果体:- 末梢神経:- 脊柱:2.13 網膜:- 目:- 動脈:2.90 静脈:- リンパ節:3.10 末梢血:- 脾臓:2.37 胸腺:3.11 骨髄:- 脂肪:- 骨:2.59 皮膚:2.39
RNA-seq 大脳:1.35 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:96.70 前立腺:61.80 卵巣:57.50 精巣:103.50 心臓:18.60 骨格筋:35.50 食道:- 胃:- 腸:37 結腸:35.20     肝臓:9.10        肺:50.20    膀胱:264.70 腎臓:64.50 下垂体:64.60 甲状腺:- 副腎:848.90 膵臓:75.10 乳腺:55.50 唾液腺:54
GeneChip 子宮:5.66 胎盤:5.92 前立腺:4.52 卵巣:6.36 精巣:8.36 心臓:4.83 骨格筋:5.12 食道:- 胃:5.29 腸:5.18 結腸:- 肝臓:5.64 肺:5.37 膀胱:6.38 腎臓:6.02 下垂体:5.52 甲状腺:- 副腎:4.88 膵臓:5.14 乳腺:5.45 唾液腺:4.63
CAGE 子宮:2.74 胎盤:2.44 前立腺:2.45 卵巣:3.31 精巣:2.60 心臓:- 骨格筋:- 食道:- 胃:2.16 腸:2.03 結腸:2.57     肝臓:2.53    肺:2.83 膀胱:3.13 腎臓:- 下垂体:2.81 甲状腺:- 副腎:3.19 膵臓:2.03 乳腺:2.61 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.67 食道:- 胃:- 腸:- 結腸:-     肝臓:3.40        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_009370
Gene ID 21812
Unigene ID Mm.197552
Probe set ID 1420893_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000007613

オーソログ対応遺伝子

ヒト[2]  NM_001130916, NM_004612
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

7641785
7813789
8117261
8117262
8140412
8268187
8605036
8883836
9434964
9449696
9856985
9879710
9921650
10030593
10349636
10433915
10521784
10725249
10885742
10949049
11042159
11076861
11217851
11285230
11544199
11641223
11675471
11850179
12047746
12070302
12391023
12466851
12477932
12520002
12546816
12588999
12666204
12773577
12838410
12842983
14580334
14610273
14612425
14681479
14729481
14764882
14996829
15142957
15247277
15342483
15350225
15459394
15489334
15548578
15657037
15744664
15761148
15761153
15769904
15820682
15850837
15963767
15976303
15993878
16141072
16141073
16344855
16601693
16602821
16806156
16845371
17071858
17078885
17126294
17168649
17197570
17274978
17418116
17530030
17530708
17534148
17634193
17657819
17673906
17878231
17911384
17977532
18005957
18029401
18095342
18252868
18257072
18287559
18310502
18316594
18337748
18438410
18469808
18474439
18474728
18572160
18586087
18625725
18676816
18718461
18796535
18804439
18821589
18832392
18945958
18990706
19096363
19147584
19165826
19398875
19398960
19462458
19494318
19501582
19520971
19531477
19538749
19556242
19561097
19580641
19584284
19619490
19653094
19679673
19757385
19951995
20042635
20147383
20171187
20346356
20436479
20471380
20603020
20607716
20713882
20962846
21062784
21127043
21131965
21266196
21267068
21282335
21297643
21402782
21491542
21518866
21530805
21593423
21604321
21731673
21832243
21841138
21852401
21876535
21947380
21984393
21998450
22028666
22037217
22202673
22326956
22388934
22399812
22451679
22485132
22498737
22560297
22584670
22706160
22773947
22859719
23065670
23103542
23213481
23248173
23307286
23340180
23342175
23546880
23562608
23565059
23624079
23661518
23712751
23770676
23770987
23868260
23918385
23946447
23950180
24089514
24127404
24344132
24347165
24355923
24474796

遺伝子オントロジー  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0001525  angiogenesis
GO:0009952  anterior/posterior pattern formation
GO:0006915  apoptosis
GO:0048844  artery morphogenesis
GO:0001824  blastocyst development
GO:0030154  cell differentiation
GO:0048870  cell motility
GO:0030199  collagen fibril organization
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0009790  embryonic development
GO:0043542  endothelial cell migration
GO:0001837  epithelial to mesenchymal transition
GO:0008354  germ cell migration
GO:0007507  heart development
GO:0001701  in utero embryonic development
GO:0001822  kidney development
GO:0002088  lens development in camera-type eye
GO:0043066  negative regulation of apoptosis
GO:0032331  negative regulation of chondrocyte differentiation
GO:0045602  negative regulation of endothelial cell differentiation
GO:0001937  negative regulation of endothelial cell proliferation
GO:0048663  neuron fate commitment
GO:0060021  palate development
GO:0060017  parathyroid gland development
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0060037  pharyngeal system development
GO:0016310  phosphorylation
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0051272  positive regulation of cellular component movement
GO:0051491  positive regulation of filopodium assembly
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0009791  post-embryonic development
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0010468  regulation of gene expression
GO:0040008  regulation of growth
GO:0043393  regulation of protein binding
GO:0031396  regulation of protein ubiquitination
GO:0006355  regulation of transcription, DNA-dependent
GO:0070723  response to cholesterol
GO:0043627  response to estrogen stimulus
GO:0007165  signal transduction
GO:0001501  skeletal system development
GO:0048705  skeletal system morphogenesis
GO:0048538  thymus development
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0016324  apical plasma membrane
GO:0016323  basolateral plasma membrane
GO:0005901  caveola
GO:0030054  cell junction
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0043235  receptor complex
GO:0005923  tight junction

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0070411  I-SMAD binding
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0046982  protein heterodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0050431  transforming growth factor beta binding
GO:0005024  transforming growth factor beta receptor activity
GO:0005025  transforming growth factor beta receptor activity, type I
GO:0004675  transmembrane receptor protein serine/threonine kinase activity
GO:0005114  type II transforming growth factor beta receptor binding
GO:0031625  ubiquitin protein ligase binding